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公开(公告)号：US10376480B2
公开(公告)日：2019-08-13
申请号：US15976613
申请日：2018-05-10
发明人： Sung Wuk Kim , Sung Soo Jun , Chang Hee Min , Young Woong Kim , Min Seok Kang , Byung Kyu Oh , Se Hwan Park , Yong Eun Kim , Duck Kim , Ji Sun Lee , Ju Hoon Oh
IPC分类号： A61K31/155 , A61K31/341 , A61K31/472 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07C279/26 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20 , A61K31/4406
摘要： A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.
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公开(公告)号：US09993446B2
公开(公告)日：2018-06-12
申请号：US15206780
申请日：2016-07-11
发明人： Sung Wuk Kim , Sung Soo Jun , Chang Hee Min , Young Woong Kim , Min Seok Kang , Byung Kyu Oh , Se Hwan Park , Yong Eun Kim , Duck Kim , Ji Sun Lee , Ju Hoon Oh
IPC分类号： A61K31/155 , A61K31/341 , A61K31/4406 , A61K31/472 , C07C279/26 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20
CPC分类号： A61K31/155 , A61K31/341 , A61K31/4406 , A61K31/472 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07C279/26 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20
摘要： A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.
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公开(公告)号：US09884821B2
公开(公告)日：2018-02-06
申请号：US14766203
申请日：2014-02-06
发明人： Chang Hee Min , Yong Eun Kim , Byung Kyu Oh , Ji Sun Lee , Hye Jin Heo , Ju Hoon Oh , Woong Cho
IPC分类号： C07D207/20 , C07D211/14 , C07D211/70 , C07D211/16
CPC分类号： C07D211/70 , C07D207/20 , C07D211/14 , C07D211/16
摘要： The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.
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公开(公告)号：US10252996B2
公开(公告)日：2019-04-09
申请号：US15841971
申请日：2017-12-14
发明人： Chang Hee Min , Yong Eun Kim , Byung Kyu Oh , Ji Sun Lee , Hye Jin Heo , Ju Hoon Oh , Woong Cho
IPC分类号： C07D207/20 , C07D211/14 , C07D211/16 , C07D211/70
摘要： The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.
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5.发明申请Biguanide Derivative, A Preparation Method Thereof, And A Pharmaceutical Composition Containing The Biguanide Derivative As An Active Ingredient 有权双胍衍生物及其制备方法以及含有双胍衍生物作为活性成分的药物组合物公开(公告)号：US20160317478A1
公开(公告)日：2016-11-03
申请号：US15206780
申请日：2016-07-11
发明人： Sung Wuk Kim , Sung Soo Jun , Chang Hee Min , Young Woong Kim , Min Seok Kang , Byung Kyu Oh , Se Hwan Park , Yong Eun Kim , Duck Kim , Ji Sun Lee , Ju Hoon Oh
IPC分类号： A61K31/155 , A61K31/341 , A61K31/472 , A61K31/4406
CPC分类号： A61K31/155 , A61K31/341 , A61K31/4406 , A61K31/472 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07C279/26 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20
摘要： A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.
摘要翻译： 提供了由式1表示的具有N1-N5取代的双胍衍生物化合物或其药学上可接受的盐的制备方法，以及含有其作为活性成分的药物组合物。 与常规药物相比，双胍衍生物可能对AMPKα的活化和低剂量的癌细胞增殖具有优异的作用，因此可用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病 ，骨质疏松症，多囊卵巢综合征，代谢综合征，癌症等
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