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公开(公告)号：US10252996B2
公开(公告)日：2019-04-09
申请号：US15841971
申请日：2017-12-14
发明人： Chang Hee Min , Yong Eun Kim , Byung Kyu Oh , Ji Sun Lee , Hye Jin Heo , Ju Hoon Oh , Woong Cho
IPC分类号： C07D207/20 , C07D211/14 , C07D211/16 , C07D211/70
摘要： The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.
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公开(公告)号：US20170073331A1
公开(公告)日：2017-03-16
申请号：US15304798
申请日：2015-04-17
发明人： Sung Wuk Kim , Hong Woo Kim , Sang Hee Yoo , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Young Woo Lee , Mi Jeong Kim , Woong Cho
IPC分类号： C07D403/12 , C07C311/47 , C07D295/13 , C07D211/14 , C07D319/18 , C07D333/20 , C07D251/18 , C07D249/14 , C07D211/54 , C07C279/04 , C07C279/08 , C07D209/44 , C07C279/16 , C07C279/06 , C07D233/91 , C07D213/38 , C07C279/12 , C07D239/42 , C07C279/24 , C07D207/16 , C07D277/46 , C07D263/48 , C07C279/26
CPC分类号： C07D403/12 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/12 , C07C279/16 , C07C279/24 , C07C279/26 , C07C311/47 , C07C311/49 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/16 , C07D209/40 , C07D209/44 , C07D211/14 , C07D211/54 , C07D213/38 , C07D213/40 , C07D233/88 , C07D233/91 , C07D239/42 , C07D249/14 , C07D251/18 , C07D251/48 , C07D263/48 , C07D277/46 , C07D295/13 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20
摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
摘要翻译： 本发明涉及用于抑制线粒体氧化磷酸化（OXPHOS）的胍化合物及其应用。 更具体地，本发明涉及通过抑制线粒体氧化磷酸化和重新编程细胞代谢来预防或治疗OXPHOS相关疾病，特别是癌症的药物组合物。
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公开(公告)号：US11465989B2
公开(公告)日：2022-10-11
申请号：US15304798
申请日：2015-04-17
发明人： Sung Wuk Kim , Hong Woo Kim , Sang Hee Yoo , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Young Woo Lee , Mi Jeong Kim , Woong Cho
IPC分类号： C07D295/13 , C07D213/38 , C07D213/40 , C07D333/20 , C07D333/16 , C07D249/14 , C07D251/18 , C07D251/48 , C07D211/14 , C07D211/54 , C07D209/44 , C07D209/40 , C07D233/88 , C07D233/91 , C07D207/46 , C07D279/08 , C07D203/12 , C07D239/42 , C07D263/48 , C07D319/18 , C07D317/58 , C07D277/46 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P5/50 , A61P13/00 , A61P21/00 , A61P35/00 , A61P35/04 , A61P9/00 , A61P19/10 , A61P1/16 , A61P15/00 , C07C279/16 , C07C311/47 , C07C311/49 , C07C279/12 , C07C279/26 , C07C279/24 , C07C279/08 , C07C279/04 , C07C279/06 , C07D403/12 , C07D207/16
摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
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公开(公告)号：US09884821B2
公开(公告)日：2018-02-06
申请号：US14766203
申请日：2014-02-06
发明人： Chang Hee Min , Yong Eun Kim , Byung Kyu Oh , Ji Sun Lee , Hye Jin Heo , Ju Hoon Oh , Woong Cho
IPC分类号： C07D207/20 , C07D211/14 , C07D211/70 , C07D211/16
CPC分类号： C07D211/70 , C07D207/20 , C07D211/14 , C07D211/16
摘要： The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.
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