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公开(公告)号：US20160340435A1
公开(公告)日：2016-11-24
申请号：US15159862
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Wei-Ting TIAN
IPC: C07K16/28 , C07K14/565 , C07K16/12 , C07K16/18 , C07K16/10
CPC classification number: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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公开(公告)号：US20180055946A1
公开(公告)日：2018-03-01
申请号：US15693503
申请日：2017-09-01
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU
CPC classification number: A61K47/65 , A61K47/60 , C07K5/1008 , C07K5/1013 , C07K7/06 , C08G65/32
Abstract: Disclosed herein are linker units comprising a center core, a plurality of linking arms, and optionally, a coupling arm. According to the embodiments of the present disclosure, the present linker units further comprises a targeting element and an effector element. Also disclosed herein are methods for treating various diseases using such linker units.
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3.发明申请Molecular constructs with targeting and effector moieties for treating central nervous system diseases 审中-公开具有用于治疗中枢神经系统疾病的靶向和效应部分的分子构建体公开(公告)号：US20160339115A1
公开(公告)日：2016-11-24
申请号：US15159834
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU
IPC: A61K47/48
CPC classification number: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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4.发明申请Peptide core-based multi-arm linkers for treating central nervous system diseases 有权用于治疗中枢神经系统疾病的基于肽芯的多臂接头公开(公告)号：US20160339110A1
公开(公告)日：2016-11-24
申请号：US15159829
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Chien-Jen Lin , Chun-Yu Lin
CPC classification number: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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公开(公告)号：US20240342298A1
公开(公告)日：2024-10-17
申请号：US18633337
申请日：2024-04-11
Applicant: Immunwork Inc.
Inventor： Hsing-Mao CHU , Yueh-Hsiang YU , Wei-Ting TIAN , Tse-Wen CHANG , Wei-Chen LIN , Shih-Syuan CHENG
CPC classification number: A61K47/6803 , A61K47/6849 , A61K47/6889 , A61P35/00
Abstract: Disclosed herein is a method of treating a tumor in a subject. The method comprises administering to the subject a molecular construct, which comprises an anti-CD38 antibody, and a plurality of lenalidomide molecules or hydrolyzed lenalidomide molecules linked to the anti-CD38 antibody. According to some embodiments of the present disclosure, the administration of the molecular construct gives rise to an effective amount of the lenalidomide molecules or the hydrolyzed lenalidomide molecules that is at least 1,000 times less than an effective amount of the lenalidomide molecule used alone or in combination with the anti-CD38 antibody for the treatment of the tumor.
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Patent Agency Ranking
公开(公告)号：US20180110872A1
公开(公告)日：2018-04-26
申请号：US15790240
申请日：2017-10-23
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Chia-Chun CHEN
CPC classification number: A61K47/65 , A61K47/55 , A61K47/641 , A61K47/6889 , C07K16/00 , C07K16/36 , C07K2317/20 , C07K2317/55 , C07K2317/56 , C07K2317/62 , C07K2317/622
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
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公开(公告)号：US20170056521A1
公开(公告)日：2017-03-02
申请号：US15253907
申请日：2016-09-01
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Li-Yun DU
IPC: A61K47/48 , C07K14/705 , C07K16/28
CPC classification number: A61K38/05 , A61K31/137 , A61K31/436 , A61K31/4545 , A61K39/44 , A61K47/64 , A61K47/65 , A61K47/68 , A61K47/6811 , A61K47/6843 , A61K47/6849 , C07K7/08 , C07K14/70521 , C07K14/70532 , C07K16/2866 , C07K16/36 , C07K2317/20 , C07K2317/622 , C07K2319/00 , C07K2319/035 , C07K2319/30 , C12N9/6459 , C12Y304/21068
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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公开(公告)号：US20160340427A1
公开(公告)日：2016-11-24
申请号：US15159863
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Jou-Han CHEN , Li-Yun DU
IPC: C07K16/28 , C07K16/12 , C07K14/565 , C07K16/10
CPC classification number: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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9.发明申请公开(公告)号：US20220064215A1
公开(公告)日：2022-03-03
申请号：US17496810
申请日：2021-10-08
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Wei-Ting TIAN , Yueh-Hsiang YU
IPC: C07K7/06
Abstract: Disclosed herein are composite polypeptide. According to various embodiments, the composite polypeptide includes a parent polypeptide and a metal binding motif capable of forming a complex with a metal cation. The composite polypeptide may be conjugated with a linker unit having a plurality of functional elements to form a multi-functional molecular construct. Alternatively, multiple composite polypeptides may be conjugated to a linker unit to form a molecular construct, or a polypeptide bundle. Linker units suitable for conjugating with the composite polypeptide having the metal binding motif are also disclosed.
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公开(公告)号：US20180264133A1
公开(公告)日：2018-09-20
申请号：US15922935
申请日：2018-03-16
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU
CPC classification number: A61K47/6889 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6817 , A61K47/6849 , A61K47/6859 , C07K16/2809 , C07K16/303 , C07K2317/622
Abstract: The present disclosure provides various linker units and molecular constructs, each of which has a targeting element and an effector element linked therewith. Methods for treating various diseases using such linker units and molecular constructs are also disclosed.
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