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1.发明授权Stocks of recombinant, replication-deficient adenovirus free of replication-competent adenovirus 失效具有无复制能力的腺病毒的重组，复制缺陷型腺病毒的库存
公开(公告)号：US5994106A
公开(公告)日：1999-11-30
申请号：US757023
申请日：1996-11-26
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/075 , C07K14/47 , C12N5/10 , C12N15/00 , C12N15/12 , C12N15/34 , C12N15/86 , C12N15/861 , C12Q1/68 , C12R1/92 , C12N15/64
CPC分类号： C12N7/00 , C07K14/005 , C07K14/4712 , C12N15/86 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y10S977/799
摘要： The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
摘要翻译： 本发明提供多重缺陷型腺病毒载体和补体细胞系。 还提供了多重缺陷型腺病毒载体的重组体和涉及使用这种重组体的基因治疗，疫苗接种等的治疗方法。
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公开(公告)号：US06482616B1
公开(公告)日：2002-11-19
申请号：US09321797
申请日：1999-05-27
IPC分类号： C12N510
CPC分类号： C12N7/00 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/4712 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y10S977/799
摘要： The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
摘要翻译： 本发明提供多重缺陷型腺病毒载体和补体细胞系。 还提供了多重缺陷型腺病毒载体的重组体和涉及使用这种重组体的基因治疗，疫苗接种等的治疗方法。
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公开(公告)号：US07195896B2
公开(公告)日：2007-03-27
申请号：US09964065
申请日：2001-09-26
IPC分类号： C12N5/10 , C12N15/64 , C12N15/861 , C12N15/86
CPC分类号： C12N7/00 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/4712 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y10S977/799
摘要： The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
摘要翻译： 本发明提供多重缺陷型腺病毒载体和补体细胞系。 还提供了多重缺陷型腺病毒载体的重组体和涉及使用这种重组体的基因治疗，疫苗接种等的治疗方法。
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公开(公告)号：US5851806A
公开(公告)日：1998-12-22
申请号：US572126
申请日：1995-12-14
IPC分类号： C12N15/09 , A61K31/70 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P37/04 , A61P43/00 , C07K14/075 , C07K14/47 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/12 , C12N15/34 , C12N15/86 , C12N15/861 , C12Q1/02 , C12Q1/68 , C12R1/92 , G01N33/15 , C12P19/34 , C12N15/11 , C12N5/16 , C12N5/22
CPC分类号： C12N15/86 , C07K14/005 , C07K14/4712 , C12N7/00 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2800/108 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： The present invention provides multiply replication deficient adenoviral vectors having a spacer in at least one replication deficient adenoviral region, as well as complementing cell lines therefor. Also provided are means of constructing the multiply replication deficient adenoviral vectors and methods of use thereof, e.g., in gene therapy.
摘要翻译： 本发明提供在至少一个复制缺陷型腺病毒区域中具有间隔基的多重复制缺陷型腺病毒载体，以及补体细胞系。 还提供构建多重复制缺陷型腺病毒载体的方法及其使用方法，例如在基因治疗中。
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5.发明授权Vectors, cells, and methods for the production of deleterious adenoviral, herpes viral and adeno-associated viral vectors 失效用于产生有害的腺病毒，疱疹病毒和腺相关病毒载体的载体，细胞和方法公开(公告)号：US06391612B1
公开(公告)日：2002-05-21
申请号：US09428507
申请日：1999-10-27
申请人： Joseph T. Bruder , Imre Kovesdi , Alena Lizonova
发明人： Joseph T. Bruder , Imre Kovesdi , Alena Lizonova
IPC分类号： C12P1934
CPC分类号： C12N15/86 , C07K14/4747 , C12N9/0075 , C12N2710/10343
摘要： The present invention provides a method of in vitro propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i.e., a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e.g., a mammalian, host-production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.
摘要翻译： 本发明提供了一种在包含阻断基因的真核（例如哺乳动物宿主生产细胞）中包含有害的，即细胞抑制性，细胞毒性或凋亡基因的病毒真核基因转移载体的体外繁殖的方法， 。 阻断基因抑制有害基因对真核宿主生产细胞的不利影响。 还提供了在本发明方法的上下文中有用的载体和细胞。
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