公开(公告)号：US20210230162A1

公开(公告)日：2021-07-29

申请号：US17153065

申请日：2021-01-20

申请人： Incyte Corporation

发明人： Le Zhao ,  Xiaozhao Wang ,  Wenyu Zhu ,  Haolin Yin ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/20 ,  C07D491/20 ,  C07D471/22 ,  C07D498/20

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20230151005A1

公开(公告)日：2023-05-18

申请号：US17933660

申请日：2022-09-20

申请人： Incyte Corporation

发明人： Peter Carlsen ,  Ken Mukai ,  Haolin Yin ,  Xiaozhao Wang ,  Wenqing Yao ,  Wenyu Zhu

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US12030883B2

公开(公告)日：2024-07-09

申请号：US17933660

申请日：2022-09-20

申请人： Incyte Corporation

发明人： Peter Carlsen ,  Ken Mukai ,  Haolin Yin ,  Xiaozhao Wang ,  Wenqing Yao ,  Wenyu Zhu

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20230226040A1

公开(公告)日：2023-07-20

申请号：US17991482

申请日：2022-11-21

申请人： Incyte Corporation

发明人： Alejandro Amador Arjona ,  Angela Abdollahi ,  Margaret Favata ,  Jonathan Rios-Doria ,  Hui Wang ,  Susan Wee ,  Pei Gan ,  Jeffrey C. Yang ,  Yong Li ,  Le Zhao ,  Chunhong He ,  Chunyin Marshall Law ,  Wenyu Zhu ,  Xiaozhao Wang ,  Wenqing Yao ,  Peter Niels Carlsen ,  Fenglei Zhang ,  Qinda Ye ,  Matthew S. McCammant ,  Rocco Policarpo ,  Artem Shvartsbart ,  Jeremy Roach ,  Gia Hoang ,  Bin Hu ,  Gencheng Li ,  Robert Susick ,  Padmaja Polam ,  Chao Qi ,  Alexander Sokolsky ,  Haolin Yin ,  Chang Min

IPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

CPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

摘要： The present disclosure relates to methods of treating cancer by administering a compound, which is a Fibroblast Growth Factor Receptor (FGFR) inhibitor, in combination with a Kirsten rat sarcoma (KRAS) inhibitor.

公开(公告)号：US20230174555A1

公开(公告)日：2023-06-08

申请号：US17823254

申请日：2022-08-30

申请人： Incyte Corporation

发明人： Gencheng Li ,  Haolin Yin ,  Chao Qi ,  Xiaozhao Wang ,  Wenqing Yao ,  Bin Hu ,  Peter Carlsen

IPC分类号： C07D519/00 ,  A61P35/00

CPC分类号： C07D519/00 ,  A61P35/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US11530218B2

公开(公告)日：2022-12-20

申请号：US17153065

申请日：2021-01-20

申请人： Incyte Corporation

发明人： Le Zhao ,  Xiaozhao Wang ,  Wenyu Zhu ,  Haolin Yin ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/20 ,  C07D471/22 ,  C07D491/20 ,  C07D498/20

摘要： Disclosed are spirocyclic compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and treating cancer, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.