公开(公告)号：US20240343742A1

公开(公告)日：2024-10-17

申请号：US18643536

申请日：2024-04-23

申请人： INCYTE CORPORATION

发明人： Peter Carlsen ,  Xiaozhao Wang ,  Alexander Sokolsky ,  Pei Gan ,  Rocco Policarpo ,  Wenqing Yao

IPC分类号： C07D519/00 ,  A61P35/00 ,  C07D455/02 ,  C07D487/02

CPC分类号： C07D519/00 ,  A61P35/00 ,  C07D455/02 ,  C07D487/02

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US11999752B2

公开(公告)日：2024-06-04

申请号：US17458964

申请日：2021-08-27

申请人： Incyte Corporation

发明人： Peter Carlsen ,  Xiaozhao Wang ,  Alexander Sokolsky ,  Pei Gan ,  Rocco Policarpo ,  Wenqing Yao

IPC分类号： C07D519/00 ,  A61P35/00 ,  C07D455/02 ,  C07D487/02

CPC分类号： C07D519/00 ,  A61P35/00 ,  C07D455/02 ,  C07D487/02

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20230226040A1

公开(公告)日：2023-07-20

申请号：US17991482

申请日：2022-11-21

申请人： Incyte Corporation

发明人： Alejandro Amador Arjona ,  Angela Abdollahi ,  Margaret Favata ,  Jonathan Rios-Doria ,  Hui Wang ,  Susan Wee ,  Pei Gan ,  Jeffrey C. Yang ,  Yong Li ,  Le Zhao ,  Chunhong He ,  Chunyin Marshall Law ,  Wenyu Zhu ,  Xiaozhao Wang ,  Wenqing Yao ,  Peter Niels Carlsen ,  Fenglei Zhang ,  Qinda Ye ,  Matthew S. McCammant ,  Rocco Policarpo ,  Artem Shvartsbart ,  Jeremy Roach ,  Gia Hoang ,  Bin Hu ,  Gencheng Li ,  Robert Susick ,  Padmaja Polam ,  Chao Qi ,  Alexander Sokolsky ,  Haolin Yin ,  Chang Min

IPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

CPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

摘要： The present disclosure relates to methods of treating cancer by administering a compound, which is a Fibroblast Growth Factor Receptor (FGFR) inhibitor, in combination with a Kirsten rat sarcoma (KRAS) inhibitor.

公开(公告)号：US20230114765A1

公开(公告)日：2023-04-13

申请号：US17812310

申请日：2022-07-13

申请人： Incyte Corporation

发明人： Zhenwu Li ,  Zhiyong YU ,  Jeremy Roach ,  Gia Hoang ,  Bin HU ,  Gencheng Li ,  Rory McAtee ,  Ken Mukai ,  Rocco Policarpo ,  Robert Susick ,  Xiaozhao Wang ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20220064188A1

公开(公告)日：2022-03-03

申请号：US17458964

申请日：2021-08-27

申请人： Incyte Corporation

发明人： Peter Carlsen ,  Xiaozhao Wang ,  Alexander Sokolsky ,  Pei Gan ,  Rocco Policarpo ,  Wenqing Yao

IPC分类号： C07D519/00 ,  C07D455/02 ,  C07D487/02 ,  A61P35/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20210355121A1

公开(公告)日：2021-11-18

申请号：US17231547

申请日：2021-04-15

申请人： Incyte Corporation

发明人： Wenyu ZHU ,  Xiaozhao WANG ,  Artem SHVARTSBART ,  Chao Qi ,  Rocco Policarpo ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61P35/00 ,  A61K9/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.