公开(公告)号：US20230203474A1

公开(公告)日：2023-06-29

申请号：US18088628

申请日：2022-12-26

Applicant: Industrial Technology Research Institute

Inventor： Ming-Chun Lin ,  Hui-Ling Cheng ,  Chun-Ting Lai ,  Hua-Cheng Chou ,  Wei-Chin Huang ,  Chih-Hung Chen ,  Shu-Feng Chen

IPC: C12N15/10 ,  C07H21/00 ,  C07D491/18 ,  C07H1/06

CPC classification number: C12N15/1006 ,  C07D491/18 ,  C07H1/06 ,  C07H21/00

Abstract: A compound, a solid carrier including the same and a method for preparing a nucleic acid are provided. The compound has a structure represented by Formula (1) as follows.





In Formula (1), the definition of Y1, Y2, Z and * are the same as defined in the detailed description.

公开(公告)号：US20240209416A1

公开(公告)日：2024-06-27

申请号：US18191864

申请日：2023-03-28

Applicant: Industrial Technology Research Institute

Inventor： Wei-Chin Huang ,  An-Li Chen ,  Ming-Chun Lin ,  Chun-Ting Lai ,  Li-Cheng Jheng ,  Sung-Ho Liu ,  Bo-Huai Wang

IPC: C12Q1/6811 ,  C08L33/26

CPC classification number: C12Q1/6811 ,  C08L33/26

Abstract: A method for modifying a surface of a substrate and a method for immobilizing oligonucleotide are provided. The method includes the following steps. A substrate is provided. A branched polymer is grafted on a surface of the substrate, wherein a side chain of a repeating unit of the branched polymer has a group capable of binding to an oligonucleotide. One end of the branched polymer has a group capable of binding to the surface of the substrate.