公开(公告)号：US20160154929A1

公开(公告)日：2016-06-02

申请号：US14605029

申请日：2015-01-26

Applicant: Institute For Information Industry

Inventor： Shao-Hua CHENG ,  Yu Shian CHIU ,  Eric Y. CHUANG ,  Tzu-Pin LU ,  Heng-Yuan TUNG

IPC: G06F19/22

CPC classification number: G16B30/00

Abstract: A next generation sequencing analysis system and a next generation sequencing analysis method thereof are provided. The next generation sequencing analysis system receives a target gene input, and decides at least one gene group of the target gene input based on gene related information stored in a gene database. The next generation sequencing analysis system adjusts a standard gene reference sequence into a featured gene reference sequence according to the at least one gene group, and compares a plurality of pieces of under-test gene fragment information with the featured gene reference sequence to obtain a gene variation rate

Abstract translation: 提供下一代测序分析系统及其下一代测序分析方法。 下一代测序分析系统接收目标基因输入，并且基于存储在基因数据库中的基因相关信息来决定目标基因输入的至少一个基因组。 下一代测序分析系统根据至少一个基因组将标准基因参考序列调整为特征基因参考序列，并将多个待测试的基因片段信息与特征基因参考序列进行比较，以获得基因 变化率

公开(公告)号：US20180144098A1

公开(公告)日：2018-05-24

申请号：US15365961

申请日：2016-12-01

Applicant: INSTITUTE FOR INFORMATION INDUSTRY

Inventor： Wei-I LIU ,  Yu-Shian CHIU ,  Joey Jen-Hui SYU ,  Chia-Shan HSIEH ,  Mong-Hsun TSAI ,  Tzu-Pin LU ,  Liang-Chuan LAI ,  Eric Y. CHUANG ,  Hui-I HSIAO

IPC: G06F19/00 ,  G06F19/12

CPC classification number: G06F19/326 ,  G16B5/00 ,  G16B25/00 ,  G16H20/10 ,  G16H50/20

Abstract: A drug combination prediction method comprising: storing a plurality of original gene sets, at least one first gene impacted by a first drug and at least one second gene impacted by a second drug; determining the part of the at least one first gene and the part of the at least one second gene to be a first interaction gene set; calculating a gene amount of the first interaction gene set to obtain a first interaction gene amount, and calculating a first percentage generated by the first interaction gene amount in the first original gene set; calculating an interaction value of the combination of the first drug and the second drug according to the first percentage; and selecting at least one synergistic pharmaceutical composition according to the interaction value.

公开(公告)号：US20170147744A1

公开(公告)日：2017-05-25

申请号：US14963196

申请日：2015-12-08

Applicant: INSTITUTE FOR INFORMATION INDUSTRY

Inventor： Chia-Yang CHENG ,  Joey Jen-Hui, SYU ,  Wei-I LIU ,  Mong-Hsun TSAI ,  Tzu-Pin LU ,  Liang-Chuan LAI ,  Eric-Y CHUANG

IPC: G06F19/22

CPC classification number: G16B30/00

Abstract: A system for analyzing sequencing data of bacterial strains and a method thereof are provided. The method for analyzing sequencing data of bacterial strains includes the following steps: searching a specific variable region of a first genetic sample sequence and searching another specific variable region of a second genetic sample sequence; determining whether both the specific variable region and the another specific variable region have an identical cross-sample subsequence; if both the specific variable region and the another specific variable region have the identical cross-sample subsequence, storing the cross-sample subsequence into a recording table; and if the identical cross-sample subsequence exists, comparing the cross-sample subsequence with a plurality of gene sequences of known strains stored in a database module to analyze a plurality of strains corresponding to the cross-sample subsequence in the first genetic sample sequence and the second genetic sample sequence.