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公开(公告)号：US11045552B2
公开(公告)日：2021-06-29
申请号：US15479071
申请日：2017-04-04
申请人： International Business Machines Corporation , Agency for Science, Technology and Research (ASTAR)
发明人： Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel H. Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
摘要： A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号：US10557008B2
公开(公告)日：2020-02-11
申请号：US15815200
申请日：2017-11-16
摘要： A porous material includes a resin material based on a trifunctional ethynyl monomer. Pores in the porous material can be of various sizes including nanoscale sizes. The porous material may be used in a variety of applications, such as those requiring materials with a high strength-to-weight ratio. The porous material can include a filler material dispersed therein. The filler material can be, for example, a particle, a fiber, a fabric, or the like. In some examples, the filler material can be a carbon fiber or a carbon nanotube. A method of making a porous material includes forming a resin including a trifunctional ethynyl monomer component and a polythioaminal component. The resin can be heated to promote segregation of the components into different phases with predominately one or the other component in each phase. Processing of the resin after phase segregation to decompose the polythioaminal component can form pores in the resin.
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公开(公告)号：US20200011797A1
公开(公告)日：2020-01-09
申请号：US16515968
申请日：2019-07-18
发明人： Michael Engel , Jeannette M. Garcia , Ricardo L. Ohta , Ademir F. Silva , Mathias B. Steiner , Jaione Tirapu Azpiroz , Thomas G. Zimmerman
IPC分类号： G01N21/64
摘要： A system is provided for performing metal trace analysis on a liquid sample. A sample holder holds an analysis substrate that includes a reference region and at least one test region. An ultraviolet (UV) light source emits ultraviolet light illuminating the liquid sample. An optical sensor detects radiation emanating from the liquid sample and converting the detected radiation into an electrical signal. A microcontroller processes the electrical signal. An external interface transmits the processed electrical signal to an external device. The analysis substrate is configured for manual movement by a user. A tracking system detects a sample scanning location for the metal trace analysis, and includes a light source, other than the UV light source, and another optical sensor. The other optical sensor detects light emitted by the light source.
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公开(公告)号：US10463746B2
公开(公告)日：2019-11-05
申请号：US15807602
申请日：2017-11-09
发明人： Dylan Boday , Wei Cheng , Jeannette M. Garcia , James Hedrick , Nathaniel H. Park , Rudy J. Wojtecki , Chuan Yang , YiYan Yang
IPC分类号： A61K47/60 , A61K47/69 , A61K31/785 , A61P35/00
摘要： Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.
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公开(公告)号：US20190218342A1
公开(公告)日：2019-07-18
申请号：US16362275
申请日：2019-03-22
CPC分类号： C08G73/0644 , C08G12/08 , C08G73/065 , G03F7/038 , G03F7/20 , G03F7/30
摘要： This disclosure describes new compositions and methods related to photoresponsive poly(hexahydrotriazines) and related polymers. In an embodiment, a method of patterning a substrate includes forming a liquid poly(hemiaminal) material by a process that includes forming a reaction mixture comprising a polar solvent, paraformaldehyde, and an aminobenzene compound having photoreactive groups, and heating the reaction mixture at a temperature up to 50° C. The method further includes applying the liquid poly(hemiaminal) material to a substrate; patterning the liquid poly(hemiaminal) material with UV light; and curing the liquid poly(hemiaminal) material to form a cured poly(hexahydrotriazine) polymer.
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公开(公告)号：US10336914B2
公开(公告)日：2019-07-02
申请号：US14924174
申请日：2015-10-27
IPC分类号： C09D183/08 , C09D5/08 , C09D201/02 , C09D5/00
摘要： Methods and compositions related to chemically active hexahydrotriazine inorganic-organic hybrid coatings are described. The coatings have affinity for sulfur compounds, and thus may bind or capture sulfur containing contaminants and gases. The coatings have organosilicon containing functional groups and segments, and may also contain silica particles, which cumulatively enhances adhesion, abrasion resistance and further provides steric barriers to gaseous diffusion. The coatings have utility as protective barrier coatings in the field of electronics.
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公开(公告)号：US10189969B2
公开(公告)日：2019-01-29
申请号：US15482369
申请日：2017-04-07
IPC分类号： C08J9/28 , C08G101/00
摘要： Silica-based organogels, including aerogels, incorporating hexahydrotriazine and/or hemiaminal species are described. These organo-silica gel materials can have applications as insulating materials. In a particular example, an aerogel includes silica groups and a hexahydrotriazine moiety with at least one nitrogen atom that is covalently linked to a silica group. Methods of making such silica-based organogels are also described.
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公开(公告)号：US10118993B2
公开(公告)日：2018-11-06
申请号：US15460785
申请日：2017-03-16
IPC分类号： C08G73/00 , C08L79/00 , C08G73/06 , C07D207/452 , C08L79/04 , C08L63/04 , C08L63/00 , C08G73/10
摘要： In some embodiments, a product, such as a thermoset, has a polyhexahydrotriazine and a self-polymerized cross-linkable polymer. In some embodiments, a product is the reaction product of a diamine, an aldehyde, and a compound having an α,β-unsaturated electron withdrawing moiety.
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公开(公告)号：US10113034B2
公开(公告)日：2018-10-30
申请号：US15334156
申请日：2016-10-25
摘要： The disclosure describes new compositions and methods related to polyaminals and related polymers. The compositions are useful as therapeutic/drug conjugates, self-healing materials, reversible crosslinking materials, degradable hydrogels, protective coatings, and as metal scavenging agents. New atom efficient synthetic schemes are disclosed, which yield previously unobtainable high molecular weight polyaminals.
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公开(公告)号：US10071161B2
公开(公告)日：2018-09-11
申请号：US15080272
申请日：2016-03-24
CPC分类号： A61K47/34 , A61K47/59 , A61K47/60 , C08G12/08 , C08G12/40 , C08G64/0216 , C08G73/06 , C08G73/0644
摘要： Method for preparing a supramolecular therapeutic agent delivery assembly are provided. A carbonate-containing precursor, a functionalized aliphatic precursor, and an aromatic diamine precursor may be combined to form an amphiphilic block co-polymer. The block co-polymer undergo a cross-linking polymerization process and a therapeutic agent may be incorporated into the resulting supramolecular assembly. The supramolecular assembly may comprise HT, PHT, HA, and/or PHA materials.
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