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6 条记录 (耗时 0.026 秒)

    Method for inhibiting heparanase activity
    2.
    发明授权
    Method for inhibiting heparanase activity 失效
    抑制肝素酶活性的方法

    公开(公告)号：US5206223A

    公开(公告)日：1993-04-27

    申请号：US583851

    申请日：1990-09-17

    申请人： Israel Vlodavsky ,  Amiram Eldor ,  Yaakov Naparstek ,  Irun Cohen

    发明人： Israel Vlodavsky ,  Amiram Eldor ,  Yaakov Naparstek ,  Irun Cohen

    IPC分类号： C08B37/10

    CPC分类号： A61K31/715 ,  Y10S514/825 ,  Y10S514/885

    摘要： Heparanase activity in a patient may be inhibited by administering an effective heparanase-inhibiting amount of heparin or an effective chemically modified derivative of heparin which inhibits heparanase activity. Such derivatives are preferably N-desulfated, N-acetylated heparin or O-desulfated, N-acetylated heparin. By means of this invention, allograft rejection may be prevented or delayed and autoimmune diseases such as arthritis may be alleviated and treated.

    摘要翻译： 可以通过施用抑制肝素酶活性的有效的乙酰肝素酶抑制量的肝素或有效的化学修饰的肝素衍生物来抑制患者中的肝素酶活性。 此类衍生物优选为N-脱硫酸，N-乙酰化肝素或O-脱硫酸，N-乙酰化肝素。 通过本发明，可以预防或延迟同种异体移植排斥反应，并且可以减轻和治疗自身免疫性疾病如关节炎。

    Method for decreasing tumor metastasis
    3.
    发明授权
    Method for decreasing tumor metastasis 失效
    减少肿瘤转移的方法

    公开(公告)号：US4882318A

    公开(公告)日：1989-11-21

    申请号：US67582

    申请日：1987-06-24

    申请人： Israel Vlodavsky ,  Amiram Eldor ,  Yaakov Naparstek ,  Irun R. Cohen

    发明人： Israel Vlodavsky ,  Amiram Eldor ,  Yaakov Naparstek ,  Irun R. Cohen

    IPC分类号： A61K31/715 ,  A61K20060101 ,  A61P35/00 ,  A61P43/00 ,  C08B37/10

    CPC分类号： A61K31/715

    摘要： The invention relates to pharmaceutical compositions intended to decrease the incidence of tumor metastasis in patients who suffer from malignant diseases.The pharmaceutical compositions of the invention contain as active ingredient heparin or a suitable derivative thereof. Amongst suitable derivatives are N-desulfated and N-acetylated heparin.The dosage of the administered heparin or heparin derivative is quite critical and will generally be in the range of from 0.05 mg/kg/day to about 0.5 mg/kg/day. A preferred range is between about 0.1 mg/kg/day to about 0.5 mg/kg/day.

    摘要翻译： 本发明涉及旨在降低患有恶性疾病的患者的肿瘤转移发生率的药物组合物。 本发明的药物组合物含有作为活性成分的肝素或其合适的衍生物。 其中合适的衍生物是N-脱硫和N-乙酰化肝素。 给药的肝素或肝素衍生物的剂量是非常关键的，通常在0.05mg / kg /天至约0.5mg / kg /天的范围内。 优选的范围为约0.1mg / kg /天至约0.5mg / kg /天。

    Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
    4.
    发明授权
    Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same 失效
    来自水蛭唾液的血小板聚集抑制剂和含有它们的药物制剂

    公开(公告)号：US5246715A

    公开(公告)日：1993-09-21

    申请号：US368880

    申请日：1989-06-20

    申请人： Miriam Orevi ,  Meir Rigbi ,  Amiram Eldor

    发明人： Miriam Orevi ,  Meir Rigbi ,  Amiram Eldor

    IPC分类号： A61K35/62 ,  A61K38/00 ,  A61L33/18 ,  C07K4/12 ,  C07K14/435 ,  C07K14/815

    CPC分类号： C07K14/815 ,  A61K35/62 ,  A61K38/005 ,  A61L33/18 ,  C07K14/43536 ,  C07K4/12 ,  Y10S530/855

    摘要： A composition of matter useful as an inhibitor of blood platelet aggregation, for the treatment of various clinical disorders such as thrombotic, inflammatory and immunological disorders. This composition of matter is derived from the saliva of leeches of the Hirudinidae family. The composition contains various components, all having molecular weights lower than 2,000 daltons. The composition has an inhibitory activity against platelet aggregation induced by various aggregating agents, including Platelet Activating Factor-acether (PAF-acether), arachidonic acid, thrombin, ADP and epinephrine.

    摘要翻译： 用作血小板聚集抑制剂的物质组合物，用于治疗各种临床疾病如血栓形成，炎症和免疫学障碍。 这种物质的组成来源于水蛭属（Hirudinidae）水蛭的唾液。 该组合物含有各种组分，全部具有低于2,000道尔顿的分子量。 该组合物对血小板聚集剂（包括血小板活化因子 - 乙酰胆碱），花生四烯酸，凝血酶，ADP和肾上腺素诱导的血小板聚集具有抑制作用。

    Acetylcholinesterase-derived peptides and uses thereof
    6.
    发明申请
    Acetylcholinesterase-derived peptides and uses thereof 审中-公开
    乙酰胆碱酯酶衍生的肽及其用途

    公开(公告)号：US20070065882A1

    公开(公告)日：2007-03-22

    申请号：US11401670

    申请日：2006-04-11

    申请人： Hermona Soreq ,  Amiram Eldor ,  Sofia Eldor ,  Varda Deutsch ,  Dan Grisaru

    发明人： Hermona Soreq ,  Amiram Eldor ,  Sofia Eldor ,  Varda Deutsch ,  Dan Grisaru

    IPC分类号： G01N33/567 ,  C07K16/40

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/18

    摘要： The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and/or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals. Further, the invention relates to antibodies against the peptides, inter alia for diagnostic use, for example, the diagnosis of stress-induced male infertility. The invention also relates to in vitro and in vivo methods for screening of drugs that affect the central nervous system, and are potential modulators of interactions between the “readthrough” form of acetylcholinesterase, AChE-R, the intracellular receptor RACK1 and the kinase PKC.

    摘要翻译： 本发明涉及包含衍生自乙酰胆碱酯酶氨基酸序列的约9至约150个氨基酸序列的细胞生长和/或分化调节肽，优选来自乙酰胆碱酯酶的C-末端区。 本发明还涉及包含这些肽的药物组合物，特别是用于促进干细胞的存活，促进干细胞的分化，促进干细胞的生长和/或促进生长因子对干细胞的生长增强作用 ，或与其他生长因子结合使用。 特别感兴趣的是在治疗血小板减少症，照射后条件，化疗后条件或大量失血后的病症中使用肽，并促进神经祖细胞在用于恢复患病个体的神经功能的细胞疗法中。 此外，本发明涉及针对肽的抗体，特别是用于诊断用途，例如应激诱导的男性不育症的诊断。 本发明还涉及用于筛选影响中枢神经系统的药物的体外和体内方法，并且是“阅读”形式的乙酰胆碱酯酶，AChE-R，细胞内受体RACK1和激酶PKC之间的相互作用的潜在调节剂。