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    Pharmaceutical compositions comprising novel oligopeptides exhibiting selective inhibiting effect upon the proliferation of hemopoietic cells
    3.
    发明授权
    Pharmaceutical compositions comprising novel oligopeptides exhibiting selective inhibiting effect upon the proliferation of hemopoietic cells 失效
    包含对造血细胞增殖具有选择性抑制作用的新型寡肽的药物组合物

    公开(公告)号：US5312812A

    公开(公告)日：1994-05-17

    申请号：US750278

    申请日：1994-05-17

    申请人： Andras Balazs ,  Istvan Schon ,  Tamas Szirtes ,  Lajos Kisfaludy, deceased

    发明人： Andras Balazs ,  Istvan Schon ,  Tamas Szirtes ,  Lajos Kisfaludy, deceased

    IPC分类号： A61K38/00 ,  A61P7/00 ,  C07K5/10 ,  C07K5/113 ,  C07K7/06 ,  A61K37/00

    CPC分类号： C07K5/1021 ,  C07K7/067 ,  A61K38/00

    摘要： The present invention relates to novel peptides of formulaeXaa Glu Asp Cys Lys (SEQ I.D. No: 1),andGlu Asp Cys Lys (SEQ I.D. No: 2)wherein the Cys sulfur is bonded to an acetamidomethyl group, and Xaa is pyro-Glu, the acid addition salts thereof, the pharmaceutical compositions comprising the same and a process for the preparation of the novel peptides and compositions.The novel peptides selectively inhibit the proliferation of hemopoietic cells.The invention also covers the treatment of mammals (including human beings) with the said peptides and compositions for selectively inhibiting the proliferation of hemopoietic cells.The advantage of the novel compounds is that they are almost completely harmless, they do not have any side-effect in therapeutic dose-range, in addition they significantly inhibit the damaging effects of drugs and radiation used for the therapy of tumorous diseases or the dose of drug or radiation can be increased when they are administered.

    摘要翻译： 本发明涉及式Xaa Glu Asp Cys Lys（SEQ ID No：1）和Glu Asp Cys Lys（SEQ ID No：2）的新型肽，其中Cys硫与乙酰氨基甲基结合，Xaa是热解 - Glu，其酸加成盐，包含其的药物组合物和制备新肽和组合物的方法。 新型肽选择性抑制造血细胞的增殖。 本发明还涵盖用所述肽和用于选择性抑制造血细胞增殖的组合物治疗哺乳动物（包括人）。 新化合物的优点是它们几乎完全无害，它们在治疗剂量范围内没有任何副作用，此外它们显着抑制用于治疗肿瘤疾病或剂量的药物和辐射的破坏作用 药物或放射线在施用时可以增加。