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    Crystalline forms of halobetasol propionate
    1.
    发明授权
    Crystalline forms of halobetasol propionate 失效
    结晶形式的丙酸卤代倍他索

    公开(公告)号：US07208485B2

    公开(公告)日：2007-04-24

    申请号：US10341690

    申请日：2003-01-13

    申请人： Itai Adin ,  Yuri Futerman ,  Ori Lerman ,  Alexander Weisman ,  Chaim Ashkenazi ,  Joseph Kaspi

    发明人： Itai Adin ,  Yuri Futerman ,  Ori Lerman ,  Alexander Weisman ,  Chaim Ashkenazi ,  Joseph Kaspi

    IPC分类号： A61K31/56 ,  C07J7/00

    CPC分类号： A61K31/56 ,  C07J7/00

    摘要： The present invention provides a crystalline halobetasol propionate selected from the group consisting of halobetasol propionate having crystalline Form I characterized by power X-ray diffraction peak positions and intensities as set forth in Table 1 herein, halobetasol propionate having crystalline Form II characterized by power X-ray diffraction peak positions and intensities as set forth in Table 2 herein, halobetasol propionate having crystalline Form III characterized by power X-ray diffraction peak positions and intensities as set forth in Table 3 herein, halobetasol propionate having crystalline Form IV characterized by power X-ray diffraction peak positions and intensities as set forth in Table 4 herein, halobetasol propionate having crystalline Form V characterized by power X-ray diffraction peak positions and intensities as set forth in Table 5 herein, and halobetasol propionate having crystalline Form VI characterized by power X-ray diffraction peak positions and intensities as set forth in Table 6 herein.

    摘要翻译： 本发明提供一种选自由具有结晶形式I的特征为结晶形式I的权利要求的表示于表1中的功能X射线衍射峰位置和强度的结晶形式的盐酸羟钴因子， 如本文表2所示的X-射线衍射峰位置和强度，具有结晶形式III的盐酸羟考沙丹，其特征在于功能X射线衍射峰位置和强度，如表3所示，具有结晶形式IV的具有结晶形式IV的功能X- 如本文表4所示的X-射线衍射峰位置和强度，具有结晶形式V的具有由表X所示的功率X射线衍射峰位置和强度表征的结晶形式V的卤代双酚S和具有结晶形式VI的十六烷醇酯，其特征在于功率X 射线衍射峰位置和强度 如本文表6所示。