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    Role of N-2-hydroxy-ethyl-piperazine-N′-2-ethane sulfonic acid (HEPES) in pain control and reversal of demyelinization injury
    1.
    发明授权
    Role of N-2-hydroxy-ethyl-piperazine-N′-2-ethane sulfonic acid (HEPES) in pain control and reversal of demyelinization injury 有权
    N-2-羟基 - 乙基 - 哌嗪-N'-2-乙磺酸（HEPES）在疼痛控制和脱髓鞘损伤逆转中的作用

    公开(公告)号：US08883855B2

    公开(公告)日：2014-11-11

    申请号：US12885404

    申请日：2010-09-17

    申请人： Ivan E. Danhof

    发明人： Ivan E. Danhof

    IPC分类号： A61K31/395 ,  A61K31/495

    CPC分类号： A61K31/495

    摘要： Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.

    摘要翻译： 本文公开了HEPES和衍生物在治疗与癌症相关的疼痛和副作用（包括化疗后认知障碍）中的组合物和治疗用途。 HEPES也用于治疗神经变性和神经疾病，脱髓鞘损伤，以及与苯二氮卓类，抗抑郁药和其他神经系统药物相关的副作用和戒断症状。

    Compositions and methods of aloe polysaccharides
    2.
    发明授权
    Compositions and methods of aloe polysaccharides 有权
    芦荟多糖的组成和方法

    公开(公告)号：US08604187B2

    公开(公告)日：2013-12-10

    申请号：US12985943

    申请日：2011-01-06

    申请人： Ivan E. Danhof

    发明人： Ivan E. Danhof

    IPC分类号： C08B37/00

    CPC分类号： A61K31/715 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/736 ,  A61K36/886 ,  A61K47/10 ,  A61K2236/17 ,  A61K2236/333 ,  A61K2236/53 ,  C08B37/0003 ,  C08B37/0006 ,  C08B37/0087 ,  C08B37/0093 ,  C08B37/0096

    摘要： The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and hepatitis C.

    摘要翻译： 本发明描述了一种从冷冻干燥的芦荟粉中制备聚甘露聚糖提取物的方法。 本发明的聚甘露聚糖进一步用于制备用于治疗一种或多种癌症，白血病和淋巴瘤，前列腺癌，乳腺癌和结肠癌，免疫疾病，特别是免疫相关肿瘤，获得性免疫缺陷的无菌可注射制剂 综合征和丙型肝炎。

    Role of N-2-Hydroxy-Ethyl-Piperazine-N'-2-Ethane Sulfonic Acid (HEPES) in Pain Control and Reversal of Demyelinization Injury
    3.
    发明申请
    Role of N-2-Hydroxy-Ethyl-Piperazine-N'-2-Ethane Sulfonic Acid (HEPES) in Pain Control and Reversal of Demyelinization Injury 有权
    N-2-羟基 - 乙基 - 哌嗪-N'-2-乙烷磺酸（HEPES）在疼痛控制和脱髓鞘损伤逆转中的作用

    公开(公告)号：US20110071157A1

    公开(公告)日：2011-03-24

    申请号：US12885404

    申请日：2010-09-17

    申请人： Ivan E. Danhof

    发明人： Ivan E. Danhof

    IPC分类号： A61K31/495 ,  A61P25/28 ,  A61P25/00 ,  A61P25/18 ,  A61P29/00 ,  A61P35/00

    CPC分类号： A61K31/495

    摘要： Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.

    摘要翻译： 本文公开了HEPES和衍生物在治疗与癌症相关的疼痛和副作用（包括化疗后认知障碍）中的组合物和治疗用途。 HEPES也用于治疗神经变性和神经疾病，脱髓鞘损伤，以及与苯二氮卓类，抗抑郁药和其他神经系统药物相关的副作用和戒断症状。

    Methods for Aloe Processing
    6.
    发明申请
    Methods for Aloe Processing 审中-公开
    芦荟加工方法

    公开(公告)号：US20120322757A1

    公开(公告)日：2012-12-20

    申请号：US13523267

    申请日：2012-06-14

    申请人： Billy C. Coats ,  Ivan E. Danhof

    发明人： Billy C. Coats ,  Ivan E. Danhof

    IPC分类号： A61K31/122 ,  A61K31/715 ,  A61P33/00 ,  A61P37/02 ,  A61P35/00 ,  A61P33/06 ,  A61K31/704 ,  A61P1/10

    CPC分类号： A61K31/122 ,  A61K36/886 ,  A61K45/06 ,  A61K2236/15 ,  A61K2236/39 ,  Y02A50/411 ,  A61K2300/00

    摘要： A composition and process for generating an anthraquinone rich aloe product from aloe leaves comprising the steps of: removing one or more rind parts from the aloe leaves comprising a top rind, a bottom rind, or both by filleting the aloe leaves on a filleting table into a mucilage layer below the rind parts of the aloe leaves to remove the top rind, the bottom rind, or both from an internal fillet or a gel layer; and separating the internal fillet or the gel layer from the rind parts; removing a mucilage layer attached to the one or more rind parts by scraping, heat-treating the rind parts and the extracted mucilage; and adding one or more preservatives to the heat-treated mucilage after cooling, wherein the extracted and heat-treated mucilage comprises the anthaquinone rich aloe product.

    摘要翻译： 一种用于从芦荟叶产生富含蒽醌的芦荟产品的组合物和方法，包括以下步骤：通过将切片上的芦荟叶倒圆，从包括顶部皮，底皮或两者的芦荟叶中去除一个或多个外皮部分， 在芦荟的外皮部分下面的粘液层离开内部圆角或凝胶层去除顶部外皮，底部外皮或两者; 并将内部圆角或凝胶层与外皮部分分离; 通过刮除，热处理外皮部分和提取的粘液来除去附着在一个或多个外皮部分上的粘液层; 并在冷却后向经热处理的胶浆中加入一种或多种防腐剂，其中提取和热处理的粘液包含富含蒽醌的芦荟产品。

    ANTI-VIRAL PROPERTIES OF ALOE VERA AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) TREATMENT
    7.
    发明申请
    ANTI-VIRAL PROPERTIES OF ALOE VERA AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) TREATMENT 审中-公开
    ALOE VERA和获得性免疫缺陷综合征（AIDS）治疗的抗病毒性质

    公开(公告)号：US20120022018A1

    公开(公告)日：2012-01-26

    申请号：US13187222

    申请日：2011-07-20

    申请人： Ivan E. Danhof

    发明人： Ivan E. Danhof

    IPC分类号： A61K31/715 ,  A61P37/00 ,  A61P31/18 ,  A61K31/736

    CPC分类号： A61K31/715 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/135 ,  A61K31/736 ,  A61K36/886 ,  A61K2300/00 ,  A23V2200/324 ,  A23V2250/06 ,  A23V2250/1882 ,  A23V2250/2102

    摘要： A pharmaceutical composition comprising a combination of formulations derived from Aloe vera for the treatment of Acquired Immune Deficiency Syndrome (AIDS) or HIV infection is described herein. The composition comprises: (i) an injectable sterile polymannan extract, (ii) Raidox (aloe anthraquinones and their diacetyl derivatives), and (iii) a freeze dried aloe vera powder, aloe vera juice, aloe gel or a combination. In addition one or more nutritional supplements comprising fatty acids, proteins, minerals and metals, vitamins, salts, amino acids, and other pharmaceutically acceptable excipients may also be include to counteract the chronic diarrhea, digestive upsets, and weight loss seen in some patients before and during the treatment course. A method for treating the AIDS or HIV infection using the composition of the present invention is also disclosed.

    摘要翻译： 本文描述了包含来自芦荟的用于治疗获得性免疫缺陷综合征（AIDS）或HIV感染的制剂的组合的药物组合物。 组合物包括：（i）可注射的无菌聚丹宁提取物，（ii）Raidox（芦荟蒽醌及其二乙酰基衍生物），和（iii）冷冻干燥的芦荟粉末，芦荟汁，芦荟凝胶或组合。 此外，还可以包括一种或多种包含脂肪酸，蛋白质，矿物质和金属的营养补充剂，维生素，盐，氨基酸和其它药学上可接受的赋形剂，以抵消在一些患者中看到的慢性腹泻，消化不良和体重减轻 并在治疗过程中。 还公开了使用本发明的组合物治疗AIDS或HIV感染的方法。

    Method of processing aloe leaves
    8.
    发明授权
    Method of processing aloe leaves 失效
    芦荟叶的处理方法

    公开(公告)号：US6083508A

    公开(公告)日：2000-07-04

    申请号：US81408

    申请日：1998-05-19

    申请人： Ramiro Estrada Avalos ,  Ivan E. Danhof

    发明人： Ramiro Estrada Avalos ,  Ivan E. Danhof

    IPC分类号： A61K36/886 ,  C07G99/00 ,  A01N65/00 ,  A61K35/78 ,  A61K39/385 ,  C07G17/00

    CPC分类号： C07G17/00 ,  A61K36/886

    摘要： A process for forming an aloe product from only the leaf residue obtained after filleting aloe leaves having an internal fillet which is removed therefrom. Further, the residue is formed into a slurry by grinding and the aloe product is generated from the slurry. Hand filleting of the aloe leaves to remove the internal fillet may be performed as a preferable alternative to machine filleting. In addition the steps of preparing the aloe product comprises cleansing an aloe leaf before filleting it, separating the slurry formed into a liquid and solids, and further treating the separated liquid to remove laxatives before forming the aloe product. Also a process including all of the above steps may also be performed in order to form the liquid.

    摘要翻译： 一种仅从叶片中获得的叶片残留物形成芦荟产品的方法，该芦荟叶片具有从其中除去的内部圆角。 此外，通过研磨将残渣形成浆料，并从浆料中产生芦荟制品。 作为机器切片的优选替代方法，可以进行芦荟叶的手工切片以去除内部圆角。 此外，制备芦荟产品的步骤包括在切碎芦荟叶子之前清洁芦荟叶，将形成的液体和固体分离，并在形成芦荟产品之前进一步处理分离的液体以除去泻药。 还可以执行包括所有上述步骤的方法以形成液体。