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    Soft, high oxygen permeability ophtalmic lens
    2.
    发明授权
    Soft, high oxygen permeability ophtalmic lens 失效
    柔软，高透氧性透视镜

    公开(公告)号：US5304584A

    公开(公告)日：1994-04-19

    申请号：US979969

    申请日：1992-11-23

    申请人： Ivan M. Nunez ,  James D. Ford ,  Frank Molock

    发明人： Ivan M. Nunez ,  James D. Ford ,  Frank Molock

    IPC分类号： C07H15/08 ,  C07H15/10 ,  C08F290/00 ,  C08F299/02 ,  C08F299/06 ,  C08G18/48 ,  C08G18/50 ,  C08G18/65 ,  C08G18/81 ,  G02B1/04 ,  G02C7/04 ,  C08F24/00

    CPC分类号： C08G18/8158 ,  C08G18/4883 ,  G02B1/043

    摘要： A low water contact lens material having high O.sub.2 permeability, a lower water content and reduced polymer matrix size provides adequate O.sub.2 to the cornea, but does not wick water away from the eye nor allow protein or other tear components to penetrate and deposit in the lens. Such a lens is made by polymerizing and crosslinking a prepolymer which contains a cyclic polyol with polyalkylether segments containing curable segments. The cyclic polyols consist of alkoxylated glucose or sucrose which are then reacted with an isocyanate to produce an ultraviolet curable prepolymer. The prepolymer is then placed in a mold and polymerized by exposure to ultraviolet light. The free hydroxyl groups of the material react with a highly hydrophilic reagent to form covalent bonds thus making the surface of the material more wettable.

    摘要翻译： 具有高O 2渗透性，较低含水量和降低的聚合物基体尺寸的低水接触透镜材料为角膜提供足够的氧气，但不将水从眼睛吸出，也不允许蛋白质或其它泪液组分穿透并沉积在镜片中 。 通过使包含环状多元醇的预聚物与包含可固化链段的聚烷基醚链段聚合和交联来制造这种透镜。 环状多元醇由烷氧基化葡萄糖或蔗糖组成，然后与异氰酸酯反应生成紫外线固化预聚物。 然后将预聚物置于模具中并通过暴露于紫外光下聚合。 该材料的游离羟基与高亲水性试剂反应形成共价键，从而使材料的表面更易于润湿。

    Ophthalmic devices comprising photochromic materials with reactive substituents
    4.
    发明授权
    Ophthalmic devices comprising photochromic materials with reactive substituents 有权
    包含具有反应性取代基的光致变色材料的眼科装置

    公开(公告)号：US09052438B2

    公开(公告)日：2015-06-09

    申请号：US11101979

    申请日：2005-04-08

    申请人： Wenjing Xiao ,  Barry Van Gemert ,  Shivkumar Mahadevan ,  Frank Molock

    发明人： Wenjing Xiao ,  Barry Van Gemert ,  Shivkumar Mahadevan ,  Frank Molock

    IPC分类号： G02C7/04 ,  G02B1/04 ,  G02B5/23 ,  G03C1/73

    CPC分类号： G02B1/041 ,  G02B1/043 ,  G02B5/23 ,  G02C7/04 ,  G03C1/73 ,  Y10T428/31935

    摘要： Various non-limiting embodiments of the present disclosure relate to ophthalmic devices comprising photochromic materials comprising a reactive substituent. For example, the present disclosure contemplates ophthalmic devices comprising photochromic materials, such as photochromic naphthopyrans and indeno-fused naphthopyrans having a reactive substituent comprising a reactive moiety linked to the photochromic naphthopyran by one or more linking groups. In certain non-limiting embodiments, the reactive moiety comprises a polymerizable moiety. In other non-limiting embodiments, the reactive moiety comprises a nucleophilic moiety. Other non-limiting embodiments of the present disclosure relate to methods of making the photochromic ophthalmic device, wherein the photochromic ophthalmic devices comprise the photochromic naphthopyrans described herein.

    摘要翻译： 本公开的各种非限制性实施方案涉及包含含有反应性取代基的光致变色材料的眼科装置。 例如，本公开涉及包含光致变色材料的光学装置，例如具有包含通过一个或多个连接基团与光致变色萘并吡喃连接的反应性部分的反应性取代基的光致变色萘并吡喃和茚并稠合萘并吡喃。 在某些非限制性实施方案中，反应性部分包含可聚合部分。 在其它非限制性实施方案中，反应性部分包含亲核部分。 本公开的其它非限制性实施方案涉及制备光致变色眼科装置的方法，其中光致变色眼科装置包含本文所述的光致变色萘并吡喃。

    Photochromic ophthalmic devices made with dual initiator system
    7.
    发明申请
    Photochromic ophthalmic devices made with dual initiator system 审中-公开
    用双引发剂体系制成的光致变色眼科装置

    公开(公告)号：US20060227287A1

    公开(公告)日：2006-10-12

    申请号：US11102319

    申请日：2005-04-08

    申请人： Frank Molock ,  Gina Cullerton ,  Shivkumar Mahadevan

    发明人： Frank Molock ,  Gina Cullerton ,  Shivkumar Mahadevan

    IPC分类号： G02C7/10

    CPC分类号： G02B1/043 ,  C08L33/10 ,  C08L33/08

    摘要： The present invention relates to a process comprising exposing a polymerizable mixture comprising at least one lens forming component, at least one thermal initiator, at least one photoinitiator and at least one photochromic compound to device forming conditions comprising heat and actinic radiation to form a photochromic ophthalmic device.

    摘要翻译： 本发明涉及包括将包含至少一种透镜形成组分，至少一种热引发剂，至少一种光引发剂和至少一种光致变色化合物的可聚合混合物暴露于包含热和光化辐射的装置形成条件，以形成光致变色眼科 设备。

    Low polydispersity poly-hema compositions
    8.
    发明申请
    Low polydispersity poly-hema compositions 有权
    低多分散性聚阴离子组成

    公开(公告)号：US20060036052A1

    公开(公告)日：2006-02-16

    申请号：US10983851

    申请日：2004-11-08

    申请人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Steensrup ,  Helene Rossignol ,  Frank Molock

    发明人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Steensrup ,  Helene Rossignol ,  Frank Molock

    IPC分类号： C08F220/26 ,  C08F118/00

    CPC分类号： C08F20/28 ,  C08F220/06 ,  C08F220/18 ,  C08F220/32 ,  G02B1/043 ,  C08L33/14

    摘要： The present invention relates to compositions comprising poly-HEMA having a peak molecular weight between about 25,000 and about 100,000, preferably between 25,000 and 80,000 and a polydispersity of less than about 2 to less than about 3.8 respectively and covalently bonded thereon, at least one cross-linkable functional group. The present invention further relates to low polydispersity poly-HEMA suitable for making the crosslinkable prepolymers, processes for functionalizing and purifying said poly-HEMA to form said crosslinkable prepolymers, viscous solutions made from said crosslinkable prepolymers, hydrogels made from said viscous solutions and articles made from said crosslinkable polymers, hydrogels and viscous solutions.

    摘要翻译： 本发明涉及包含聚合HEMA的组合物，其具有分子量约25,000至约100,000，优选25,000至80,000，多分散度分别小于约2至小于约3.8并且共价键合在其上，至少一个交叉 可链接的功能组。 本发明还涉及适用于制备可交联预聚物的低分散性聚HEMA，用于官能化和纯化所述聚HEMA以形成所述可交联预聚物的方法，由所述可交联预聚物制成的粘性溶液，由所述粘性溶液制成的水凝胶和制品 来自所述可交联聚合物，水凝胶和粘稠溶液。