公开(公告)号：US20180360318A1

公开(公告)日：2018-12-20

申请号：US16015659

申请日：2018-06-22

申请人： Ivana Ledesma

发明人： RALPH ZUCKERMAN

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14555 ,  A61B5/14556 ,  A61B5/4842 ,  A61B5/7246 ,  A61B5/7278 ,  G01N21/6445 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2201/0683 ,  G01N2201/12

摘要： A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.

公开(公告)号：US20170150887A1

公开(公告)日：2017-06-01

申请号：US15288840

申请日：2016-10-07

申请人： Ivana Ledesma

发明人： RALPH ZUCKERMAN

IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/145

CPC分类号： A61B5/0071 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14555 ,  A61B5/14556 ,  A61B5/4842 ,  A61B5/7246 ,  A61B5/7278 ,  G01N21/6445 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2201/0683 ,  G01N2201/12

摘要： A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.

公开(公告)号：US20190254526A1

公开(公告)日：2019-08-22

申请号：US16253633

申请日：2019-01-22

申请人： Ivana Ledesma

发明人： RALPH ZUCKERMAN

IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  G01N21/64

摘要： A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.

公开(公告)号：US20160174845A1

公开(公告)日：2016-06-23

申请号：US14974550

申请日：2015-12-18

申请人： Ivana Ledesma

发明人： RALPH ZUCKERMAN

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14555 ,  A61B5/14556 ,  A61B5/4842 ,  A61B5/7246 ,  A61B5/7278 ,  G01N21/6445 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2201/0683 ,  G01N2201/12

摘要： A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.