利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

87 条记录 (耗时 0.026 秒)

    Angiotensin II receptor antagonists
    1.
    发明授权
    Angiotensin II receptor antagonists 有权
    血管紧张素II受体拮抗剂

    公开(公告)号：US07880014B2

    公开(公告)日：2011-02-01

    申请号：US12000247

    申请日：2007-12-11

    申请人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    发明人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    IPC分类号： C07D257/00 ,  C07D403/00

    CPC分类号： C07D403/10

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5-; Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构的化合物，其中R是血管紧张素受体拮抗剂活性基团，Y是-Y1-Y2-Y3-Y4-Y5-; Y1是C（R1R2）; R 1选自氢和C 1-4烷基; R 2选自氢，C 1-4烷基和-OC（O）C 1-4烷基; Y2是O或CH2; Y 3是C（O）或CH 2; Y4是O或CH2; Y 5是 - （CH 2）1-2 - （X）0-1 - （CH 2）0-1-或不存在; X是-O-或-CR 3 R 4 - ; 并且R 3和R 4独立地选自氢和C 1 -C 4烷基; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    ANGIOTENSIN II RECEPTOR ANTAGONISTS
    2.
    发明申请
    ANGIOTENSIN II RECEPTOR ANTAGONISTS 审中-公开
    ANGIOTENSIN II受体拮抗剂

    公开(公告)号：US20100152259A1

    公开(公告)日：2010-06-17

    申请号：US12516482

    申请日：2007-12-11

    申请人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    发明人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    IPC分类号： C07D403/10 ,  A61K31/4184 ,  A61P9/12

    CPC分类号： C07D403/10

    摘要： A compound having the structure (Formula I), wherein R an angiotensin receptor antagonist active group, Y is Y1—Y2—Y3—Y4—Y5. Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and -0C(0)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is —(CH2)1-2—(X)0-1—CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构（式I）的化合物，其中R为血管紧张素受体拮抗剂活性基团，Y为Y1-Y2-Y3-Y4-Y5。 Y1是C（R1R2）; R 1选自氢和C 1-4烷基; R 2选自氢，C 1-4烷基和-C（O）C 1-4烷基; Y2是O或CH2; Y 3是C（O）或CH 2; Y4是O或CH2; Y 5是 - （CH 2）1-2 - （X）0-1-CH 2）0-1-或不存在; X是-O-或-CR 3 R 4 - ; 并且R 3和R 4独立地选自氢和C 1 -C 4烷基; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    Angiotensin II receptor antagonists
    3.
    发明授权
    Angiotensin II receptor antagonists 有权
    血管紧张素II受体拮抗剂

    公开(公告)号：US07834042B2

    公开(公告)日：2010-11-16

    申请号：US12312225

    申请日：2007-12-11

    申请人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali

    发明人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali

    IPC分类号： A61K31/41 ,  C07D257/04

    CPC分类号： C07D209/10 ,  C07C65/21 ,  C07C215/82 ,  C07C217/92 ,  C07D209/12 ,  C07D307/80 ,  C07D319/18 ,  C07D401/06 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04

    摘要： A compound having the structure (Formula I), wherein Y is —Y1—Y2—Y3—Y4—Y5—; Y1 is C(O) or C(R1R2); Y2 is O, C(O), P(O)(OH) or CH2, provided that when Y1 is C(O), Y2 is not C(O); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the pup consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y3 is O, C(O) or CH2, provided that when Y2 is C(O), then Y3 is not C(O), and further provided that when Y2 is O, then Y3 is not O; Y4 is O or CH2 or is absent, provided that when Y3 is O, then Y4 is not O; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构（式I）的化合物，其中Y为-Y1-Y2-Y3-Y4-Y5-; Y1是C（O）或C（R1R2）; Y2是O，C（O），P（O）（OH）或CH2，条件是当Y1是C（O）时，Y2不是C（O）; R 1选自氢和C 1-4烷基; R2选自由氢，C 1-4烷基和-OC（O）C 1-4烷基组成的小鼠; Y3为O，C（O）或CH2，条件是当Y2为C（O）时，Y3不为C（O），进一步规定，当Y2为O时，Y3不为O; Y4为O或CH2或不存在，条件是当Y 3为O时，Y 4不为O; Y 5是 - （CH 2）1-2 - （X）0-1 - （CH 2）0-1-或不存在; X是-O-或-CR 3 R 4 - ; 并且R 3和R 4独立地选自氢和C 1 -C 4烷基; 或其药学上可接受的盐，其可用于治疗高血压。

    Angiotensin II receptor antagonists
    4.
    发明申请
    Angiotensin II receptor antagonists 有权
    血管紧张素II受体拮抗剂

    公开(公告)号：US20080194660A1

    公开(公告)日：2008-08-14

    申请号：US12000247

    申请日：2007-12-11

    申请人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    发明人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    IPC分类号： A61K31/41 ,  C07D257/04 ,  A61P9/12

    CPC分类号： C07D403/10

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5-; Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有其中R是血管紧张素受体拮抗剂活性基团的结构的化合物，Y是-Y 1 -Y 2 -Y 3 -Y 3， SUP> 4 Y 1是C（R 1 R 2）2）。 R 1选自氢和C 1-4烷基; R 2选自氢，C 1-4烷基和-OC（O）C 1-4烷基; Y 2是O或CH 2; Y 3是C（O）或CH 2 O 2; Y 4是O或CH 2; （CH 2）2 - （X）0-1 - （CH 3） 0-1 <或>不存在; X是-O-或-CR 3 R 4 - 。 和R 3和R 4独立地选自氢和C 1 -C 4烷基 ; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    Angiotensin II receptor antagonists
    10.
    发明授权
    Angiotensin II receptor antagonists 失效
    血管紧张素II受体拮抗剂

    公开(公告)号：US08293777B2

    公开(公告)日：2012-10-23

    申请号：US12629419

    申请日：2009-12-02

    申请人： Michael Man-Chu Lo ,  Amjad Ali ,  Ravi P. Nargund

    发明人： Michael Man-Chu Lo ,  Amjad Ali ,  Ravi P. Nargund

    IPC分类号： A61K31/34 ,  A61K31/41 ,  C07D249/00 ,  C07D409/02

    CPC分类号： C07D403/10 ,  C07D235/08 ,  C07D257/04 ,  C07D409/06

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of —O—C1-6 alkyl, —O-aryl, —O-heteroaryl, —O—C3-8 cycloalkyl, —C1-6 alkyl, -aryl, -heteroaryl, and —C3-8 cycloalkyl; R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有其中R为血管紧张素受体拮抗剂活性基团且Y为Y的结构的化合物选自R 1选自-O-C 1-6烷基，-O-芳基，-O- 杂芳基，-O-C 3-8环烷基，-C 1-6烷基， - 芳基， - 杂芳基和-C 3-8环烷基; R2和R3独立地选自氢和C 1-4烷基，或其药学上可接受的盐或水合物，其可用于治疗高血压。