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公开(公告)号：US20080315082A1
公开(公告)日：2008-12-25
申请号：US12078680
申请日：2008-04-03
申请人： Izumi Ogata , Yasushi Terui
发明人： Izumi Ogata , Yasushi Terui
IPC分类号： B01D59/44
CPC分类号： H01J49/004
摘要： A tandem mass spectrometer comprising an ion source for ionizing a sample, an ion trap section for carrying out collision induced dissociation of the target ions thereby to produce fragment ions, a multi electrode collision section for conducting collision induced dissociation of fragment ions discharged from the ion trap section, a mass spectrometer section for conducting mass spectrometric analysis of the converged fragment ions. After the target ions selected by the ion trap section are subjected to collision induced dissociation, specific fragment ions among the fragment ions are selected and transferred to the multi electrode collision section thereby to carry out collision induced dissociation therein.
摘要翻译： 一种串联质谱仪，包括用于离子化样品的离子源，用于进行目标离子的碰撞诱导解离从而产生碎片离子的离子捕获部分，用于进行从离子排出的碎片离子的碰撞诱导解离的多电极碰撞部分 捕获部分，用于进行会聚碎片离子的质谱分析的质谱仪部分。 在由离子阱部分选择的目标离子经受碰撞诱导解离之后，选择碎片离子之间的特定碎片离子并将其转移到多电极碰撞部分，从而在其中进行碰撞诱导解离。
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公开(公告)号：US08129674B2
公开(公告)日：2012-03-06
申请号：US12078680
申请日：2008-04-03
申请人： Izumi Ogata , Yasushi Terui
发明人： Izumi Ogata , Yasushi Terui
CPC分类号： H01J49/004
摘要： A tandem mass spectrometer comprising an ion source for ionizing a sample, an ion trap section for carrying out collision induced dissociation of the target ions thereby to produce fragment ions, a multi electrode collision section for conducting collision induced dissociation of fragment ions discharged from the ion trap section, a mass spectrometer section for conducting mass spectrometric analysis of the converged fragment ions. After the target ions selected by the ion trap section are subjected to collision induced dissociation, specific fragment ions among the fragment ions are selected and transferred to the multi electrode collision section thereby to carry out collision induced dissociation therein.
摘要翻译： 一种串联质谱仪，包括用于离子化样品的离子源，用于进行目标离子的碰撞诱导解离从而产生碎片离子的离子捕获部分，用于进行从离子排出的碎片离子的碰撞诱导解离的多电极碰撞部分 捕获部分，用于进行会聚碎片离子的质谱分析的质谱仪部分。 在由离子阱部分选择的目标离子经受碰撞诱导解离之后，选择碎片离子之间的特定碎片离子并将其转移到多电极碰撞部分，从而在其中进行碰撞诱导解离。
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公开(公告)号：US07462817B2
公开(公告)日：2008-12-09
申请号：US11723995
申请日：2007-03-23
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.
摘要翻译： 本发明意在确定难以通过分离单元彼此分离并且不能被MS鉴别的混合化合物之间的存在比例。 在具有MSn分析功能的质谱仪中，用于将从分离单元洗脱的样品离子化，用于将样品分离成单独的组分，将所需质量数的离子分段，并进行碎片离子的质量分析，质谱仪包括数据库 在每个异构体的质谱中存储异构体存在比和特定离子强度比之间的相关信息。 甚至对于异构体的混合样品（如对映异构体）也可以澄清异构体比例，这些异构体难以通过分离单元彼此分离并且不能被MS鉴别。
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公开(公告)号：US20070164212A1
公开(公告)日：2007-07-19
申请号：US11723995
申请日：2007-03-23
IPC分类号： H01J49/00
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.
摘要翻译： 本发明意在确定难以通过分离单元彼此分离并且不能被MS鉴别的混合化合物之间的存在比例。 在具有MS分析功能的质谱仪中，用于将从分离单元洗脱的样品离子化以将样品分离成单个组分，使所需质量数的离子分段，并进行片段的质量分析 离子，质谱仪包括存储每个异构体的质谱中异构体存在比和特定离子强度比之间相关信息的数据库。 甚至对于异构体的混合样品（如对映异构体）也可以澄清异构体比例，这些异构体难以通过分离单元彼此分离并且不能被MS鉴别。
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公开(公告)号：US20050258355A1
公开(公告)日：2005-11-24
申请号：US11132174
申请日：2005-05-19
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.
摘要翻译： 本发明意在确定难以通过分离单元彼此分离并且不能被MS鉴别的混合化合物之间的存在比例。 在具有MS分析功能的质谱仪中，用于将从分离单元洗脱的样品离子化以将样品分离成单个组分，使所需质量数的离子分段，并进行片段的质量分析 离子，质谱仪包括存储每个异构体的质谱中异构体存在比和特定离子强度比之间相关信息的数据库。 甚至对于异构体的混合样品（如对映异构体）也可以澄清异构体比例，这些异构体难以通过分离单元彼此分离并且不能被MS鉴别。
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6.发明申请公开(公告)号：US20120298881A1
公开(公告)日：2012-11-29
申请号：US13575734
申请日：2010-11-04
申请人： Izumi Ogata
发明人： Izumi Ogata
IPC分类号： G01J3/443
CPC分类号： G01N30/74 , G01J3/12 , G01J3/4406 , G01N21/645 , G01N2021/6417 , G01N2021/6423
摘要： Disclosed is a spectrophotofluorometer, which can shorten a measuring time by efficiently obtaining a three-dimensional spectral disposition, reduce sample deterioration and reduce the size of the obtained data. The spectrophotofluorometer is provided with a sample cell housing a sample, the components of which are analyzed; an excitation light side spectroscope for irradiating onto the sample cell excitation light with a predetermined wavelength; a fluorescence side spectroscope for dispersing the fluorescence from the sample cell by scanning a predetermined range of wavelength; a fluorescence detector for detecting the fluorescence from the fluorescence side spectroscope; and a computer for obtaining a three-dimensional spectral disposition of the fluorescence intensity in the sample on the basis of the wavelength and the intensity of the fluorescence detected by the fluorescence detector while changing the wavelength of the excitation light irradiated onto the sample cell by the excitation light side spectroscope. The computer sets a plurality of combinations of the range of wavelengths of the excitation light dispersed by the excitation light side spectroscope and the range of wavelengths of the fluorescence dispersed by the fluorescence side spectroscope.
摘要翻译： 公开了一种分光光度计，其可以通过有效获得三维光谱配置来缩短测量时间，减少样品劣化并减小获得的数据的大小。 分光光度计设置有容纳样品的样品池，其组分被分析; 用于对具有预定波长的样品池激发光照射的激发光侧分光器; 用于通过扫描预定范围的波长来分散来自样品池的荧光的荧光侧分光器; 用于检测来自荧光侧分光器的荧光的荧光检测器; 以及计算机，用于基于由荧光检测器检测到的荧光的波长和强度，同时改变照射到样品池上的激发光的波长，从而获得样品中的荧光强度的三维光谱布置 激发光侧分光镜。 计算机设置由激发光侧分光器分散的激发光的波长范围和由荧光侧分光器分散的荧光的波长范围的多个组合。
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公开(公告)号：US07211790B2
公开(公告)日：2007-05-01
申请号：US11132174
申请日：2005-05-19
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.
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公开(公告)号：US20050159902A1
公开(公告)日：2005-07-21
申请号：US11037043
申请日：2005-01-19
申请人： Izumi Ogata , Shinya Ito , Yasuhiro Takegawa , Kisaburo Deguchi , Hiroaki Nakagawa , Shin-Ichiro Nishimura
发明人： Izumi Ogata , Shinya Ito , Yasuhiro Takegawa , Kisaburo Deguchi , Hiroaki Nakagawa , Shin-Ichiro Nishimura
CPC分类号： H01J49/0036 , G16C20/20
摘要： In a database MSn spectrum search, search of a known compound whose principal chain is identical to that of an unknown compound is enabled, thereby allowing analysis of an entire structure even if the entire structures of the known compound in database and that of the measured unknown compound are not identical. The MSn spectrum obtained in the MSn measurement of the unknown compound is compared with all the MSm spectra (m≧1) in the database regardless of MSn generation. In the MSn measurement of a series of related compounds including various types of different side chains of the same principal chain, such as in the case of biopolymers, it becomes possible to determine the structure of the principal chain using a database search even if the entire structure is not clear. And the estimation of the entire structure is made possible on the basis of the principal chain structure.
摘要翻译： 在数据库MS搜索中，搜索其主链与未知化合物的主链相同的已知化合物，从而允许分析整个结构，即使已知化合物的整个结构 在数据库中和测量的未知化合物的数据不相同。 将未知化合物的MS 测量中获得的MS 光谱与所有MS谱（m> = 1）进行比较 数据库，无论MS n 生成。 在一系列相关化合物（包括同一主链的各种不同侧链的相关化合物）的测定中，例如在生物聚合物的情况下，可以确定主链的结构 使用数据库搜索即使整个结构不清楚。 而整个结构的估计是可以在主链结构的基础上进行的。
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