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1.发明申请GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS 审中-公开GUANINE RIBOSWITCH BINDING化合物及其作为抗生素的用途公开(公告)号：US20120122819A1
公开(公告)日：2012-05-17
申请号：US13377052
申请日：2010-06-14
IPC分类号： A61K31/675 , A61K31/513 , C07D279/06 , A61K31/54 , C07D265/06 , A61K31/535 , C07D213/73 , A61K31/4412 , A61K31/505 , C07F9/6533 , C07D487/04 , C07D498/04 , A61K31/519 , C07F9/6584 , A61K31/5383 , G01N33/50 , A61P31/04 , C12Q1/68 , C07D239/50
CPC分类号： A61K31/675 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/519 , A61K31/535 , A61K31/5383 , A61K31/54 , A61K31/542 , C07D239/46 , C07D239/48 , C07D239/50 , C07D498/04 , C07D513/04 , Y10T436/141111 , Y10T436/143333
摘要： The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.
摘要翻译： 本发明包括所述化合物的新化合物和药学上可接受的制剂，其对具有控制guaA基因表达的鸟嘌呤核糖开关的微生物具有抗生素活性，包括对某些抗生素家族具有抗性的生物体，并且其可用作抗细菌剂 治疗或预防动物或人类的细菌感染，特别是但不限于乳腺感染，或其作为防腐剂的用途，用于灭菌或消毒的试剂。
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2.发明授权Steroid alkaloids and uses thereof as antimicrobial agents against electron transport-deficient microbes and as potentiators for antimicrobial agents against pathogenic bacteria 有权类固醇生物碱及其作为抗电子传递缺陷微生物的抗微生物剂的用途，以及作为抗病原菌抗微生物剂的增效剂公开(公告)号：US09457033B2
公开(公告)日：2016-10-04
申请号：US13984991
申请日：2012-02-15
申请人： François Malouin , Gabriel Mitchell , Kamal Bouarab , Eric Marsault , Felix Chagnon , Simon Boulanger , Isabelle Guay
发明人： François Malouin , Gabriel Mitchell , Kamal Bouarab , Eric Marsault , Felix Chagnon , Simon Boulanger , Isabelle Guay
IPC分类号： A61K31/58 , A01N45/00 , A61K31/7036 , C07J43/00 , A61K31/395 , A61L2/16 , C07J7/00 , C07J41/00 , C07J51/00
CPC分类号： A61K31/58 , A01N45/00 , A61K31/395 , A61K31/7036 , A61L2/16 , C07J7/002 , C07J7/006 , C07J7/007 , C07J7/0085 , C07J41/005 , C07J41/0055 , C07J43/003 , C07J43/006 , C07J51/00 , G01N2800/52 , A61K2300/00
摘要： The present invention includes novel compounds based on the tomatidine skeleton as well as composition comprising these compounds alone and in combination with known compounds, which exhibit antimicrobial activity against extracellular or intracellular electron transport-deficient microbes and/or increase the antimicrobial activity of aminoglycoside antibiotics against their targets, and which are useful as antibacterial agents for treatment or prophylaxis of monomicrobiotic or polymicrobic bacterial infections or for the reduction of antibiotic resistance development in animals or in humans, or for use as antiseptics or agents for sterilization or disinfection.
摘要翻译： 本发明包括基于西马齿蛋白骨架的新化合物以及单独包含这些化合物的组合物和与已知化合物组合的组合物，其具有抗细胞外或细胞内电子转运缺陷微生物的抗微生物活性和/或增加氨基糖苷类抗生素的抗微生物活性 它们的靶标，并且其可用作用于治疗或预防单生或多微生物细菌感染的抗菌剂或用于在动物或人体中降低抗生素耐药性发展，或用作消毒剂或用于灭菌或消毒的试剂。
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3.发明申请STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AGAINST ELECTRON TRANSPORT-DEFICIENT MICROBES AND AS POTENTIATORS FOR ANTIMICROBIAL AGENTS AGAINST PATHOGENIC BACTERIA 有权甾体碱性成分及其作为抗电泳剂的电子运输缺陷型微生物的抗微生物剂及其作为致病菌的抗微生物剂的潜力公开(公告)号：US20140018312A1
公开(公告)日：2014-01-16
申请号：US13984991
申请日：2012-02-15
申请人： François Malouin , Gabriel Mitchell , Kamal Bouarab , Eric Marsault , Felix Chagnon , Simon Boulanger , Isabelle Guay
发明人： François Malouin , Gabriel Mitchell , Kamal Bouarab , Eric Marsault , Felix Chagnon , Simon Boulanger , Isabelle Guay
IPC分类号： A61K31/58 , A01N45/00 , A61K31/7036 , C07J43/00 , A61K31/395
CPC分类号： A61K31/58 , A01N45/00 , A61K31/395 , A61K31/7036 , A61L2/16 , C07J7/002 , C07J7/006 , C07J7/007 , C07J7/0085 , C07J41/005 , C07J41/0055 , C07J43/003 , C07J43/006 , C07J51/00 , G01N2800/52 , A61K2300/00
摘要： The present invention includes novel compounds based on the tomatidine skeleton as well as composition comprising these compounds alone and in combination with known compounds, which exhibit antimicrobial activity against extracellular or intracellular electron transport-deficient microbes and/or increase the antimicrobial activity of aminoglycoside antibiotics against their targets, and which are useful as antibacterial agents for treatment or prophylaxis of monomicrobiotic or polymicrobic bacterial infections or for the reduction of antibiotic resistance development in animals or in humans, or for use as antiseptics or agents for sterilization or disinfection.
摘要翻译： 本发明包括基于西马齿蛋白骨架的新化合物以及单独包含这些化合物的组合物和与已知化合物组合的组合物，其具有抗细胞外或细胞内电子转运缺陷微生物的抗微生物活性和/或增加氨基糖苷类抗生素的抗微生物活性 它们的靶标，并且其可用作用于治疗或预防单生或多微生物细菌感染的抗菌剂或用于在动物或人体中降低抗生素耐药性发展，或用作消毒剂或用于灭菌或消毒的试剂。
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