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26 条记录 (耗时 0.021 秒)

    Therapeutic catheter with displacement sensing transducer
    1.
    发明授权
    Therapeutic catheter with displacement sensing transducer 有权
    带位移传感器的治疗导管

    公开(公告)号：US08282599B2

    公开(公告)日：2012-10-09

    申请号：US11941472

    申请日：2007-11-16

    申请人： Alan Eskuri ,  Daniel Lafontaine

    发明人： Alan Eskuri ,  Daniel Lafontaine

    IPC分类号： A61M25/095

    CPC分类号： A61B5/00 ,  A61B5/061 ,  A61B5/6848 ,  A61B8/12 ,  A61B17/3478 ,  A61B18/24 ,  A61B2017/0003 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61B2090/062 ,  A61B2090/0811 ,  A61M5/46 ,  A61M25/0084

    摘要： A catheter device having a proboscis, such as a needle, and a transducer which detects the axial displacement of the proboscis in relation to the distal tip of the catheter. The transducer is positioned at a distal portion of the catheter and may comprise an induction coil or a potentiometer. Axial displacement of the proboscis changes the amount of inductance or resistance in the transducer. This change in inductance or resistance can be calibrated to the amount of axial displacement of the proboscis and provided as feedback to the user.

    摘要翻译： 具有诸如针的长鼻子的导管装置和检测长鼻相对于导管的远端的轴向位移的换能器。 换能器定位在导管的远端部分，并且可以包括感应线圈或电位计。 长鼻子的轴向位移会改变传感器的电感或电阻。 电感或电阻的这种变化可以校准到长鼻子的轴向位移量，并作为反馈提供给用户。

    THERAPEUTIC CATHETER WITH DISPLACEMENT SENSING TRANSDUCER
    3.
    发明申请
    THERAPEUTIC CATHETER WITH DISPLACEMENT SENSING TRANSDUCER 有权
    带位移感应传感器的治疗导管

    公开(公告)号：US20080140006A1

    公开(公告)日：2008-06-12

    申请号：US11941472

    申请日：2007-11-16

    申请人： Alan Eskuri ,  Daniel Lafontaine

    发明人： Alan Eskuri ,  Daniel Lafontaine

    IPC分类号： A61M25/095

    CPC分类号： A61B5/00 ,  A61B5/061 ,  A61B5/6848 ,  A61B8/12 ,  A61B17/3478 ,  A61B18/24 ,  A61B2017/0003 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61B2090/062 ,  A61B2090/0811 ,  A61M5/46 ,  A61M25/0084

    摘要： A catheter device having a proboscis, such as a needle, and a transducer which detects the axial displacement of the proboscis in relation to the distal tip of the catheter. The transducer is positioned at a distal portion of the catheter and may comprise an induction coil or a potentiometer. Axial displacement of the proboscis changes the amount of inductance or resistance in the transducer. This change in inductance or resistance can be calibrated to the amount of axial displacement of the proboscis and provided as feedback to the user.

    摘要翻译： 具有诸如针的长鼻子的导管装置和检测长鼻相对于导管的远端的轴向位移的换能器。 换能器定位在导管的远端部分，并且可以包括感应线圈或电位计。 长鼻子的轴向位移会改变传感器的电感或电阻。 电感或电阻的这种变化可以校准到长鼻子的轴向位移量，并作为反馈提供给用户。

    Nucleic acid enzyme for RNA cleavage
    4.
    发明授权
    Nucleic acid enzyme for RNA cleavage 失效
    用于RNA切割的核酸酶

    公开(公告)号：US07148044B1

    公开(公告)日：2006-12-12

    申请号：US09699667

    申请日：2000-10-30

    申请人： Jean-Pierre Perreault ,  Sirinart Ananvoranich ,  Daniel Lafontaine

    发明人： Jean-Pierre Perreault ,  Sirinart Ananvoranich ,  Daniel Lafontaine

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/123

    摘要： A method is described for cleaving a nucleic acid substrate with a nucleic acid enzyme at a cleavage site comprising mixing the substrate with the enzyme, wherein the substrate includes a 7 nucleotide sequence with at least 6 nucleotides 3′ to the cleavage site and at least 1 nucleotide 5′ to the cleavage site and of formula: 5′-H′GNNHNN-3′ wherein each N is a nucleotide which may be the same or different, H is a nucleotide selected from the group consisting of A, U, C, and T, and is the site of cleavage, and H′ is a ribonucleotide selected from the group consisting of A, U, and C, wherein (i) the first nucleotide 3′ to the cleavage site is capable of forming a wobble pair with the enzyme, (ii) the second, third, fifth, and sixth nucleotides 3′ to the cleavage site are capable of forming conventional Watson-Crick base pairs with the enzyme, (iii) the fourth nucleotide 3′ to the cleavage site is capable of forming a non-conventional Watson-Crick base pair with the enzyme, and (iv) the first nucleotide 5′ to the cleavage site does not form a base pair with the enzyme; and the enzyme comprises a substrate binding portion which is capable of base pairing to the 6 nucleotides 3′ to the cleavage site of the substrate and which binding portion comprises the sequence: 3′-UNNXNN-5′ wherein each N is a nucleotide which may be the same or different, and X is a nucleotide selected from the group consisting of T, U, A, and G, whereby binding of the substrate to the enzyme effects cleavage of the substrate at the cleavage site.

    摘要翻译： 描述了一种用于在切割位点用核酸酶切割核酸底物的方法，包括将底物与酶混合，其中所述底物包含与切割位点具有至少6个核苷酸3'的7个核苷酸序列和至少1个 核苷酸5'至切割位点，并具有下式：<？in-line-formula description =“In-line formula”end =“lead”？> 5'-H'GNNHNN-3'<？in-line-formula description =“内联式”末端=“尾”→其中每个N是可以相同或不同的核苷酸，H是选自A，U，C和T的核苷酸，并且是 切割位点，H'是选自A，U和C的核糖核苷酸，其中（i）切割位点的第一个核苷酸3'能够与酶形成摆动对，（ii） 切割位点的第二，第三，第五和第六核苷酸3'能够与酶形成常规的沃森 - 克里克碱基对，（iii）第四核 到切割位点的3'能够与酶形成非常规的Watson-Crick碱基对，和（iv）切割位点的第一个核苷酸5'不与酶形成碱基对; 并且该酶包括能够与基底的切割位点的6'核苷酸3'碱基配对的底物结合部分，并且该结合部分包含以下序列：<？in-line-formula description =“In-line Formulas” end =“lead”？> 3'-UNNXNN-5'<？in-line-formula description =“In-line Formulas”end =“tail”？>其中每个N是可以相同或不同的核苷酸， 并且X是选自T，U，A和G的核苷酸，由此底物与酶的结合在切割位点处影响底物的切割。

    Apparatus and method for treating occluded vasculature
    6.
    发明申请
    Apparatus and method for treating occluded vasculature 有权
    用于治疗闭塞性脉管系统的装置和方法

    公开(公告)号：US20050288695A1

    公开(公告)日：2005-12-29

    申请号：US10877340

    申请日：2004-06-24

    申请人： Mark Jenson ,  William Drasler ,  Daniel Lafontaine

    发明人： Mark Jenson ,  William Drasler ,  Daniel Lafontaine

    IPC分类号： A61B17/00 ,  A61B17/22

    CPC分类号： A61B17/3207 ,  A61B2017/00398 ,  A61B2017/22044 ,  A61B2017/22077

    摘要： Occluded vasculature such as occluded arterial vasculature can be recanalized using a device that is configured to penetrate an occlusion, while limiting a distance that said penetration structure can extend in order to limit inadvertent vascular damage. The device can include an elongate sheath and a stylet disposed within the elongate sheath. The elongate sheath and the stylet can include, in combination, an engagement section that is configured to limit relative axial movement between the elongate sheath and the stylet.

    摘要翻译： 封闭的脉管系统如闭塞的动脉脉管系统可以使用被配置为穿透闭塞的装置再次通气，同时限制所述穿透结构可以延伸的距离，以限制无意的血管损伤。 该装置可以包括细长护套和设置在细长护套内的探针。 细长护套和探针可以组合地包括被配置为限制细长护套和探针之间的相对轴向运动的接合部分。

    Treating internal body tissue
    7.
    发明申请
    Treating internal body tissue 有权
    治疗内部身体组织

    公开(公告)号：US20060212027A1

    公开(公告)日：2006-09-21

    申请号：US11082677

    申请日：2005-03-17

    申请人： Nassir Marrouche ,  Daniel Lafontaine

    发明人： Nassir Marrouche ,  Daniel Lafontaine

    IPC分类号： A61B18/02 ,  A61B18/04

    CPC分类号： A61B18/02 ,  A61B18/04 ,  A61B2017/00243 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212

    摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.

    摘要翻译： 本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。 例如，该系统可用于消融组织作为心房颤动的治疗。 在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。 在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

    Percutaneous myocardial revascularization
    8.
    发明申请
    Percutaneous myocardial revascularization 失效
    经皮心肌血运重建

    公开(公告)号：US20080314394A9

    公开(公告)日：2008-12-25

    申请号：US11191056

    申请日：2005-07-28

    申请人： Louis Ellis ,  Daniel Lafontaine ,  Roger Hastings ,  Lauri DeVore

    发明人： Louis Ellis ,  Daniel Lafontaine ,  Roger Hastings ,  Lauri DeVore

    IPC分类号： A61B19/00 ,  A61B18/18

    CPC分类号： A61B17/3207 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/22077 ,  A61B2017/3488 ,  A61B2018/00273 ,  A61B2018/00291 ,  A61B2018/00392 ,  A61B2018/144 ,  A61B2090/395 ,  A61M2210/125

    摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.

    摘要翻译： 在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。 一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。 合适的渠道模式包括线和阵列。 一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。 另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。 另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。 另一种方法是利用多线射频燃烧探头，同时形成多个通道。 另一种方法利用液氮引起局部组织死亡。

    Leadless Cardiac Stimulation Systems
    9.
    发明申请
    Leadless Cardiac Stimulation Systems 有权
    无引导心脏刺激系统

    公开(公告)号：US20070150037A1

    公开(公告)日：2007-06-28

    申请号：US11683577

    申请日：2007-03-08

    申请人： Roger Hastings ,  William Drasler ,  Daniel Lafontaine ,  Anupama Sadasiva ,  Scott Smith

    发明人： Roger Hastings ,  William Drasler ,  Daniel Lafontaine ,  Anupama Sadasiva ,  Scott Smith

    IPC分类号： A61N1/05

    CPC分类号： A61N1/3756 ,  A61N1/0587 ,  A61N1/059 ,  A61N1/08 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/37241 ,  A61N1/37288 ,  A61N1/375 ,  A61N1/3787

    摘要： Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrodes that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Each of the electrodes contains a source of electrical energy for pacing the myocardium and is adapted to receive electromagnetic energy from a source outside the myocardium. The system also includes a source adapted for placement outside the myocardium and that uses locally measured electrocardiograms to synchronize pacing of the heart by sending electromagnetic commands to the electrodes to pace the myocardium surrounding the electrodes. Also disclosed is various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

    摘要翻译： 提供了使用无引线电极来提供起搏治疗的各种构造的系统。 在一个示例中，提供用于心脏心肌的多个部位的系统包括使用经皮，经腔，导管递送系统可植入位于心肌附近的位置的无线起搏电极。 每个电极包含用于起搏心肌的电能源，并且适于从心肌外部的源接收电磁能。 该系统还包括适于放置在心肌外部的源，并且使用局部测量的心电图来通过向电极发送电磁命令来同步心脏的起搏，以对电极周围的心肌进行加速。 还公开了用于递送和植入电极组件的这种系统，无线电极组件和输送导管的各种配置。