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公开(公告)号：US20130157953A1
公开(公告)日：2013-06-20
申请号：US13574197
申请日：2011-01-20
申请人： Jørgen Søberg Petersen , Anne Louise Kjoelbye , Marie Skovgaard , Henrik Duelund Pedersen , Lene Axelsen , Ditte Riber , Eddi Meier , Rie Schultz Hansen , Keld Fosgerau , Bjarne Due Larsen
发明人： Jørgen Søberg Petersen , Anne Louise Kjoelbye , Marie Skovgaard , Henrik Duelund Pedersen , Lene Axelsen , Ditte Riber , Eddi Meier , Rie Schultz Hansen , Keld Fosgerau , Bjarne Due Larsen
IPC分类号： C07K14/605 , C07K14/47
CPC分类号： C07K14/605 , A61K38/26 , C07K14/4705
摘要： The invention relates to the treatment of cardiac dysfunction. In particular, certain compounds, believed to be glucagon-GLP-1 dual agonist compounds, exert a positive inotropic effect while preserving the energy balance of the heart, and so may be superior to known inotropic agents such as dobutamine, norepinephrine and glucagon.
摘要翻译： 本发明涉及心脏功能障碍的治疗。 特别地，被认为是胰高血糖素-GLP-1双重激动剂化合物的某些化合物在保持心脏的能量平衡的同时发挥正性肌力作用，因此可以优于已知的肌力药如多巴酚丁胺，去甲肾上腺素和胰高血糖素。
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公开(公告)号：US08642541B2
公开(公告)日：2014-02-04
申请号：US13139678
申请日：2008-12-15
申请人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
发明人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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公开(公告)号：US08642540B2
公开(公告)日：2014-02-04
申请号：US13139482
申请日：2008-12-15
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供了用于促进体重减轻或预防体重增加以及治疗糖尿病，代谢综合征和相关疾病的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20110293587A1
公开(公告)日：2011-12-01
申请号：US13139678
申请日：2008-12-15
申请人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
发明人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
IPC分类号： A61K38/26 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N1/11 , C12N5/10 , C12N1/15 , A61K31/7088 , A61K48/00 , A61K35/74 , A61K35/68 , A61K36/06 , A61K35/64 , A61K35/12 , A61K36/064 , A61K36/00 , A61P9/10 , A61P3/10 , A61P9/12 , A61P3/04 , A61P9/00 , A61P3/06 , A61P29/00 , A61P1/16 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加以及治疗糖尿病，代谢综合征和相关疾病的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20110286982A1
公开(公告)日：2011-11-24
申请号：US13139493
申请日：2008-12-15
IPC分类号： A61K38/26 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N1/11 , C12N1/15 , C12N5/10 , A61K48/00 , A61K31/7088 , A61P3/04 , A61P3/00 , A61P29/00 , A61P1/16 , A61P25/00 , A61P3/08 , A61P3/10 , A61P9/12 , A61P3/06 , A61P9/10 , A61P9/00 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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公开(公告)号：US20110286981A1
公开(公告)日：2011-11-24
申请号：US13139487
申请日：2008-12-15
申请人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
发明人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
IPC分类号： A61K38/26 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N1/11 , C12N5/10 , C12N1/15 , A61K31/7088 , A61K48/00 , A61K35/74 , A61K35/68 , A61K36/06 , A61K35/64 , A61K35/12 , A61K36/064 , A61K36/00 , A61P9/10 , A61P3/10 , A61P9/12 , A61P3/04 , A61P9/00 , A61P3/06 , A61P29/00 , A61P1/16 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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公开(公告)号：US08685919B2
公开(公告)日：2014-04-01
申请号：US13139493
申请日：2008-12-15
IPC分类号： A61K38/00
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加以及治疗糖尿病，代谢综合征和相关疾病的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US08680049B2
公开(公告)日：2014-03-25
申请号：US13139487
申请日：2008-12-15
申请人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
发明人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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公开(公告)号：US20110293586A1
公开(公告)日：2011-12-01
申请号：US13139482
申请日：2008-12-15
IPC分类号： A61K38/26 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N1/11 , C12N5/10 , C12N1/15 , A61K31/7088 , A61K48/00 , A61K35/74 , A61K35/68 , A61K36/06 , A61K35/64 , A61K35/12 , A61K36/064 , A61K36/00 , A61P9/10 , A61P3/10 , A61P9/12 , A61P3/04 , A61P9/00 , A61P3/06 , A61P29/00 , A61P1/16 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供了用于促进体重减轻或预防体重增加以及治疗糖尿病，代谢综合征和相关疾病的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US07153822B2
公开(公告)日：2006-12-26
申请号：US10353549
申请日：2003-01-29
申请人： Peter Holme Jensen , Bjarne Due Larsen , Lars Bo Laurenborg Hansen , Jørgen Søberg Petersen , Soren Neve , Morten Schak Nielsen , Eddi Meier , Eva Steiness
发明人： Peter Holme Jensen , Bjarne Due Larsen , Lars Bo Laurenborg Hansen , Jørgen Søberg Petersen , Soren Neve , Morten Schak Nielsen , Eddi Meier , Eva Steiness
CPC分类号： A61K38/06 , A61K38/05 , A61K38/07 , A61K38/08 , G01N33/5082 , G01N33/6887 , G01N2500/10 , G01N2800/326
摘要： Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.
摘要翻译： 公开了调节细胞，组织或器官中半通道功能的组合物和方法。 本发明还涉及用于检测这些化合物的有用屏幕，特别是那些能调节连接蛋白磷酸化的化合物。 还提供了用于预防或治疗受哺乳动物例如心律失常的不需要的半通道功能影响的病症的治疗方法。
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