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公开(公告)号：US20110020950A1
公开(公告)日：2011-01-27
申请号：US12747074
申请日：2008-12-11
申请人： Jörg Vogel , Mark Edward Perry , Claus Hélix Nielsen , Jesper Søndergaard Hansen , Peter Holme Jensen , Oliver Geschke , Pierre-Yves Bolinger
发明人： Jörg Vogel , Mark Edward Perry , Claus Hélix Nielsen , Jesper Søndergaard Hansen , Peter Holme Jensen , Oliver Geschke , Pierre-Yves Bolinger
IPC分类号： G01N33/566 , B01J19/00 , C12Q1/48 , B29C35/08
CPC分类号： B01D69/02 , B01D67/006 , B01D69/10 , B01D71/32 , B01D2325/02 , B01D2325/021 , G01N33/6872
摘要： Disclosed herein is a membrane scaffold comprising a planar material having a hydrophobic surface and a functional area comprising a plurality of apertures. The apertures have a diameter of from about 80 μm to about 3000 μm and the rims of the apertures comprise bulges extending above and/or below the surface level of the planar material. The membrane scaffold is useful in the preparation of a composite biomimetic membrane wherein functional channel forming molecules have been incorporated in said membrane.
摘要翻译： 本文公开了一种膜支架，其包括具有疏水表面的平面材料和包括多个孔的功能区域。 孔的直径为约80μm至约3000μm，并且孔的边缘包括在平面材料的表面水平面上方和/或下方延伸的凸起。 膜支架可用于制备复合仿生膜，其中功能性通道形成分子已经并入所述膜。
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2.发明申请Biomimetic Water Membrane Comprising Aquaporins Used in the Production of Salinity Power 有权包含用于生产盐度电力的水通道蛋白的仿生水膜公开(公告)号：US20090007555A1
公开(公告)日：2009-01-08
申请号：US12067448
申请日：2006-09-20
申请人： Peter Holme Jensen
发明人： Peter Holme Jensen
IPC分类号： F03G7/06
CPC分类号： B01D71/74 , B01D61/002 , B01D69/02 , B01D69/10 , B01D69/141 , B01D69/142 , B01D71/06 , B01D71/80 , F03G7/005 , Y02E10/36
摘要： The present invention relates to the use of aquaporin containing membranes in the production of salinity power. The membranes are preferably lipid bilayers incorporating reconstituted aquaporin channels, e.g. entrapped between porous support materials, or alternatively enclosing a highly hydrophobic porous support material. Also disclosed is a salinity power plant.
摘要翻译： 本发明涉及含水通道蛋白的膜在生产盐度的作用。 膜优选为包含重构的水通道蛋白通道的脂质双层，例如。 夹带在多孔支撑材料之间，或者另外包围高度疏水的多孔支撑材料。 还公开了盐碱发电厂。
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公开(公告)号：US20080300180A1
公开(公告)日：2008-12-04
申请号：US11720477
申请日：2005-11-29
IPC分类号： A61K9/127 , A61K38/18 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , C07K7/00 , C07K5/00 , C07K14/475 , A61P3/00
CPC分类号： C07K5/1016 , C07K5/0812 , C07K5/101 , C07K14/60
摘要： The present invention relates to new growth hormone secretagogue receptor 1A (GHS-R 1A) ligands, and pharmaceutical compositions comprising any of the new GHS-R1 A ligands. The ligands are suitable for a wide range of applications, and thus the present invention also relates to use of the GHS-R1 A ligands according to the present invention in the manufacture of a medicament for the treatment of an individual in need thereof. In another aspect, the present invention relates to a method of treatment of an individual in need thereof, comprising administering to said individual one or more of the GHS-R1A ligands disclosed herein, such as e.g. for treatment of cancer cachexia.
摘要翻译： 本发明涉及新的生长激素促分泌素受体1A（GHS-R 1A）配体，以及包含任何新的GHS-R1A配体的药物组合物。 配体适用于广泛的应用，因此本发明还涉及根据本发明的GHS-R1A配体在制备用于治疗有需要的个体的药物中的用途。 另一方面，本发明涉及治疗有此需要的个体的方法，包括向所述个体施用本文公开的一种或多种GHS-R1A配体，例如， 用于治疗癌症恶病质。
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公开(公告)号：US07153822B2
公开(公告)日：2006-12-26
申请号：US10353549
申请日：2003-01-29
申请人： Peter Holme Jensen , Bjarne Due Larsen , Lars Bo Laurenborg Hansen , Jørgen Søberg Petersen , Soren Neve , Morten Schak Nielsen , Eddi Meier , Eva Steiness
发明人： Peter Holme Jensen , Bjarne Due Larsen , Lars Bo Laurenborg Hansen , Jørgen Søberg Petersen , Soren Neve , Morten Schak Nielsen , Eddi Meier , Eva Steiness
CPC分类号： A61K38/06 , A61K38/05 , A61K38/07 , A61K38/08 , G01N33/5082 , G01N33/6887 , G01N2500/10 , G01N2800/326
摘要： Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.
摘要翻译： 公开了调节细胞，组织或器官中半通道功能的组合物和方法。 本发明还涉及用于检测这些化合物的有用屏幕，特别是那些能调节连接蛋白磷酸化的化合物。 还提供了用于预防或治疗受哺乳动物例如心律失常的不需要的半通道功能影响的病症的治疗方法。
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公开(公告)号：US20120080377A1
公开(公告)日：2012-04-05
申请号：US13252449
申请日：2011-10-04
申请人： Peter Holme Jensen , Jesper Sondergaard Hansen , Thomas Vissing , Mark Edward Perry , Claus Helix Nielsen
发明人： Peter Holme Jensen , Jesper Sondergaard Hansen , Thomas Vissing , Mark Edward Perry , Claus Helix Nielsen
CPC分类号： B01D69/10 , A61M1/16 , A61M1/1654 , A61M1/1656 , A61M1/1666 , A61M1/1672 , A61M1/1676 , B01D11/0415 , B01D11/0446 , B01D11/0492 , B01D61/002 , B01D61/246 , B01D61/38 , B01D61/40 , B01D61/58 , B01D63/02 , B01D63/04 , B01D63/10 , B01D69/02 , B01D69/06 , B01D69/08 , B01D69/144 , B01D2325/00 , C02F1/26 , C02F1/44 , C02F1/442 , C02F1/444 , C02F1/445 , C02F2101/10 , C02F2103/08 , G01N33/582 , Y02A20/131
摘要： A liquid membrane system is disclosed in the form of a biochannel containing bulk liquid membrane (BLM), biochannel containing emulsion liquid membrane (ELM), and biochannel containing supported (immobilised) liquid membrane (SLM), or a combination thereof, wherein said liquid membrane system is based on vesicles formed from amphiphilic compounds such as lipids forming a bilayer wherein biochannels have been incorporated and wherein said vesicles further contain a stabilising oil phase. The uses of the membrane system include water extraction from liquid aqueous media by forward osmosis, e.g. for desalination of salt water.
摘要翻译： 以含有大量液体膜（BLM），含生物通道的乳液液膜（ELM）和含有支持（固定化）液膜（SLM）的生物通道）或其组合的生物通道的形式公开了液膜系统，其中所述液体 膜系统基于由两亲化合物形成的囊泡，例如形成双层的脂质，其中已经并入生物通道，并且其中所述囊泡还含有稳定油相。 膜系统的用途包括通过正向渗透从液体水性介质中提取水。 用于海水淡化盐水。
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6.发明授权Biomimetic water membrane comprising aquaporins used in the production of salinity power 有权包含用于生产盐度电力的水通道蛋白的生物模拟水膜公开(公告)号：US08123948B2
公开(公告)日：2012-02-28
申请号：US12067448
申请日：2006-09-20
申请人： Peter Holme Jensen
发明人： Peter Holme Jensen
IPC分类号： B01D65/00
CPC分类号： B01D71/74 , B01D61/002 , B01D69/02 , B01D69/10 , B01D69/141 , B01D69/142 , B01D71/06 , B01D71/80 , F03G7/005 , Y02E10/36
摘要： The present invention provides methods for producing salinity power using pressure retarded osmosis and a biometric membrane (e.g., a liquid bilayer membrane or a lipid membrane containing multiple bilayers of fused deposited lipid vesicles) containing aquaporin water channels. The invention also provides power plants for producing salinity energy using pressure retarded osmosis and a biometric water membrane containing functional aquaporin channels.
摘要翻译： 本发明提供了使用压力延迟渗透产生盐度功率的方法和含有水通道蛋白水通道的生物测定膜（例如，含有融合沉积的脂质囊泡的多个双层的液体双层膜或脂质膜）。 本发明还提供了使用压阻渗透产生盐度能的发电厂和含有功能性水通道通道的生物测定水膜。
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公开(公告)号：US20090120874A1
公开(公告)日：2009-05-14
申请号：US11915121
申请日：2006-05-19
CPC分类号： B01D69/10 , B01D69/02 , B01D69/141 , B01D69/142 , B01D71/74 , C02F1/44 , C02F1/441 , C02F1/442 , C07K14/705 , Y02A20/131
摘要： Disclosed are novel water membranes comprising lipid bilayers incorporating functional aqua-porins. The lipid bilayers are arranged in sandwich structures including hydrophilic or hydro-phobic support materials. Also disclosed are water purification devices/systems, including reverse osmosis filtering devices that include membranes having functional aquaporins. Methods of water purification and methods of preparing the membranes are also disclosed. Further, the invention provides for a new type of perforated, hydrophobic polymer film and to membranes containing lipid bilayers having other transmembrane proteins than aquaporins introduced.
摘要翻译： 公开了包含掺入功能性水孔蛋白的脂质双层的新型水膜。 脂双层布置在包括亲水或疏水支撑材料的夹层结构中。 还公开了水净化装置/系统，包括反渗透过滤装置，其包括具有功能水通道蛋白的膜。 还公开了水净化方法和制备膜的方法。 此外，本发明提供了一种新型的穿孔疏水性聚合物膜和含有比引入水通道蛋白的其它跨膜蛋白的脂质双层的膜。
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公开(公告)号：US07857978B2
公开(公告)日：2010-12-28
申请号：US11915121
申请日：2006-05-19
IPC分类号： B01D69/02
CPC分类号： B01D69/10 , B01D69/02 , B01D69/141 , B01D69/142 , B01D71/74 , C02F1/44 , C02F1/441 , C02F1/442 , C07K14/705 , Y02A20/131
摘要： Disclosed are novel water membranes comprising lipid bilayers incorporating functional aqua-porins. The lipid bilayers are arranged in sandwich structures including hydrophilic or hydro-phobic support materials. Also disclosed are water purification devices/systems, including reverse osmosis filtering devices that include membranes having functional aquaporins. Methods of water purification and methods of preparing the membranes are also disclosed. Further, the invention provides for a new type of perforated, hydrophobic polymer film and to membranes containing lipid bilayers having other transmembrane proteins than aquaporins introduced.
摘要翻译： 公开了包含掺入功能性水孔蛋白的脂质双层的新型水膜。 脂双层布置在包括亲水或疏水支撑材料的夹层结构中。 还公开了水净化装置/系统，包括反渗透过滤装置，其包括具有功能水通道蛋白的膜。 还公开了水净化方法和制备膜的方法。 此外，本发明提供了一种新型的穿孔疏水性聚合物膜和含有比引入水通道蛋白的其它跨膜蛋白的脂质双层的膜。
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公开(公告)号：US07585839B2
公开(公告)日：2009-09-08
申请号：US10646294
申请日：2003-08-22
申请人： Bjarne Due Larsen , Jorgen Soberg Petersen , Eddi Meier , Anne Louise Kjolbye , Niklas Rye Jorgensen , Morten Schak Neilsen , Neils-Henrik Holstein-Rathlou , James B. Martins , Peter Holme Jensen
发明人： Bjarne Due Larsen , Jorgen Soberg Petersen , Eddi Meier , Anne Louise Kjolbye , Niklas Rye Jorgensen , Morten Schak Neilsen , Neils-Henrik Holstein-Rathlou , James B. Martins , Peter Holme Jensen
IPC分类号： A61K38/12
CPC分类号： A61K31/551 , A61K31/365 , A61K38/12 , A61K47/645
摘要： Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
摘要翻译： 公开了包括具有改善的稳定性的抗心律不齐肽的新型肽。 进一步公开的是包括这些肽的组合物以及将组合物特别用作药物的方法。
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