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    MHC peptide complexes and uses thereof in infectious diseases
    3.
    发明授权
    MHC peptide complexes and uses thereof in infectious diseases 有权
    MHC肽复合物及其在感染性疾病中的应用

    公开(公告)号：US08268964B2

    公开(公告)日：2012-09-18

    申请号：US12619039

    申请日：2009-11-16

    申请人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    发明人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K16/00 ,  A61K38/16

    CPC分类号： C07K14/70539 ,  A61K38/00 ,  A61K47/61 ,  A61K47/6425 ,  A61K49/1896 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56972 ,  G01N33/56977 ,  G01N33/574 ,  G01N2333/70539 ,  G01N2800/24 ,  Y02A50/401 ,  Y02A50/55 ,  Y02A50/57 ,  Y02A50/58

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

    摘要翻译： 公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。 这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。 特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。 向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如， 在治疗和诊断领域。 本发明一般涉及治疗领域，包括治疗方法和治疗组合物。 本发明还包括MHC复合物和MHC多聚体的样品安装用途。

    MHC Peptide Complexes and Uses Thereof in Infectious Diseases
    4.
    发明申请
    MHC Peptide Complexes and Uses Thereof in Infectious Diseases 有权
    MHC肽复合物及其在传染病中的应用

    公开(公告)号：US20100226854A1

    公开(公告)日：2010-09-09

    申请号：US12619039

    申请日：2009-11-16

    申请人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    发明人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    IPC分类号： A61K39/00 ,  C07K14/74 ,  A61P31/12 ,  C12N9/96 ,  C07K16/00 ,  C12N5/07 ,  A61K51/08 ,  A61K39/395 ,  C12Q1/02 ,  C12N5/0783

    CPC分类号： C07K14/70539 ,  A61K38/00 ,  A61K47/61 ,  A61K47/6425 ,  A61K49/1896 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56972 ,  G01N33/56977 ,  G01N33/574 ,  G01N2333/70539 ,  G01N2800/24 ,  Y02A50/401 ,  Y02A50/55 ,  Y02A50/57 ,  Y02A50/58

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

    摘要翻译： 公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。 这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。 特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。 向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如， 在治疗和诊断领域。 本发明一般涉及治疗领域，包括治疗方法和治疗组合物。 本发明还包括MHC复合物和MHC多聚体的样品安装用途。

    MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES
    5.
    发明申请
    MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES 审中-公开
    MHC肽复合物及其在感染性疾病中的应用

    公开(公告)号：US20120264161A1

    公开(公告)日：2012-10-18

    申请号：US13482472

    申请日：2012-05-29

    申请人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    发明人： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    IPC分类号： C07K19/00 ,  C12N5/0783 ,  C12Q1/02

    CPC分类号： C07K14/70539 ,  A61K38/00 ,  A61K47/61 ,  A61K47/6425 ,  A61K49/1896 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56972 ,  G01N33/56977 ,  G01N33/574 ,  G01N2333/70539 ,  G01N2800/24 ,  Y02A50/401 ,  Y02A50/55 ,  Y02A50/57 ,  Y02A50/58

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

    摘要翻译： 公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。 这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。 特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。 向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如， 在治疗和诊断领域。 本发明一般涉及治疗领域，包括治疗方法和治疗组合物。 本发明还包括MHC复合物和MHC多聚体的样品安装用途。

    MHC multimers in borrelia diagnostics and disease
    7.
    发明授权
    MHC multimers in borrelia diagnostics and disease 有权

    公开(公告)号：US10968269B1

    公开(公告)日：2021-04-06

    申请号：US12919405

    申请日：2008-12-30

    申请人： Jørgen Schøller ,  Liselotte Brix ,  Henrik Pedersen

    发明人： Jørgen Schøller ,  Liselotte Brix ,  Henrik Pedersen

    IPC分类号： C07K14/74 ,  A61K39/00

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules containing one or more Borrelia derived peptides are disclosed. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the sample-mounted use of MHC complexes and MHC multimers.
    Also comprised by the invention is the field of therapy and vaccine, including therapeutic/vaccine methods and therapeutic/vaccine compositions.

    MHC peptide complexes and uses thereof in infectious diseases
    10.
    发明授权
    MHC peptide complexes and uses thereof in infectious diseases 有权

    公开(公告)号：US10336808B2

    公开(公告)日：2019-07-02

    申请号：US13482472

    申请日：2012-05-29

    申请人： Jøgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    发明人： Jøgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    IPC分类号： C07K14/74 ,  A61K47/64 ,  G01N33/569 ,  A61K49/18 ,  G01N33/574 ,  A61K47/61 ,  A61K38/00

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.