公开(公告)号：US20240166984A1

公开(公告)日：2024-05-23

申请号：US18283748

申请日：2022-03-23

申请人： JANSSEN BIOTECH, INC.

发明人： Caitlin O'MAHONY-BARTNETT ,  Barry J. MC CARTHY ,  Christopher W. RODE ,  Ronan HAYES ,  Fiona MADDEN ,  Jingjie MO ,  Francis C. MASLANKA ,  Kevin CLARK ,  Daniel A. TROUT ,  Pushpraj RANA ,  Emmanouela GRATSIA ,  Carl RAFFERTY ,  Karin M. BALSS ,  Olav LYNGBERG

IPC分类号： C12M1/36 ,  C12M1/00 ,  C12M1/34 ,  G16C20/20 ,  G16C20/70

CPC分类号： C12M41/48 ,  C12M29/10 ,  C12M41/26 ,  C12M41/32 ,  G16C20/20 ,  G16C20/70

摘要： Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.

公开(公告)号：US20240168033A1

公开(公告)日：2024-05-23

申请号：US18283694

申请日：2022-03-22

申请人： JANSSEN BIOTECH, INC.

发明人： Caitlin O'MAHONY-HARTNETT ,  Barry J. MC CARTHY ,  Christopher W. RODE ,  Ronan HAYES ,  Fiona MADDEN ,  Jingjie MO ,  Francis C. MASLANKA ,  Kevin CLARK ,  Daniel A. TROUT ,  Pushpraj RANA ,  Emmanouela GRATSIA ,  Carl RAFFERTY ,  Karin M. BALSS ,  Olav LYNGBERG

IPC分类号： G01N33/68 ,  C07K1/107 ,  C12M1/34 ,  G16B40/10 ,  G16C20/20

CPC分类号： G01N33/6803 ,  C07K1/1077 ,  C12M41/32 ,  G16B40/10 ,  G16C20/20 ,  G01N2400/10

摘要： Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.