公开(公告)号：US20240166984A1

公开(公告)日：2024-05-23

申请号：US18283748

申请日：2022-03-23

Applicant: JANSSEN BIOTECH, INC.

Inventor： Caitlin O'MAHONY-BARTNETT ,  Barry J. MC CARTHY ,  Christopher W. RODE ,  Ronan HAYES ,  Fiona MADDEN ,  Jingjie MO ,  Francis C. MASLANKA ,  Kevin CLARK ,  Daniel A. TROUT ,  Pushpraj RANA ,  Emmanouela GRATSIA ,  Carl RAFFERTY ,  Karin M. BALSS ,  Olav LYNGBERG

IPC: C12M1/36 ,  C12M1/00 ,  C12M1/34 ,  G16C20/20 ,  G16C20/70

CPC classification number: C12M41/48 ,  C12M29/10 ,  C12M41/26 ,  C12M41/32 ,  G16C20/20 ,  G16C20/70

Abstract: Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.

公开(公告)号：US20240168033A1

公开(公告)日：2024-05-23

申请号：US18283694

申请日：2022-03-22

Applicant: JANSSEN BIOTECH, INC.

Inventor： Caitlin O'MAHONY-HARTNETT ,  Barry J. MC CARTHY ,  Christopher W. RODE ,  Ronan HAYES ,  Fiona MADDEN ,  Jingjie MO ,  Francis C. MASLANKA ,  Kevin CLARK ,  Daniel A. TROUT ,  Pushpraj RANA ,  Emmanouela GRATSIA ,  Carl RAFFERTY ,  Karin M. BALSS ,  Olav LYNGBERG

IPC: G01N33/68 ,  C07K1/107 ,  C12M1/34 ,  G16B40/10 ,  G16C20/20

CPC classification number: G01N33/6803 ,  C07K1/1077 ,  C12M41/32 ,  G16B40/10 ,  G16C20/20 ,  G01N2400/10

Abstract: Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.

公开(公告)号：US20230160829A1

公开(公告)日：2023-05-25

申请号：US17990887

申请日：2022-11-21

Applicant: JANSSEN BIOTECH, INC. ,  OHIO STATE INNOVATION FOUNDATION

Inventor： Karin M. BALSS ,  Zachary SCHULTZ ,  Courtney J. MORDER

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/569

CPC classification number: G01N21/658 ,  G01J3/44 ,  G01N33/56983 ,  G01N2201/1293 ,  G06F17/10

Abstract: Disclosed is a method of quantifying virus titer in a sample using Raman spectroscopy. This method comprises providing a sample; providing a model for determining viral titer in the sample; irradiating the sample with a light source; and acquiring a Raman spectrum of the sample. The method further involves quantifying the viral titer of the sample by applying a virus component of the Raman spectrum to the model for determining viral titer. Other aspects of the disclosure relate to a method for generating a model suitable for quantifying viral titer in a sample.