公开(公告)号：US20180042948A1

公开(公告)日：2018-02-15

申请号：US15555721

申请日：2016-03-04

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu KANAI ,  Yohei SOMA ,  Yusuke SHIMIZU ,  Atsuhiko TANIGUCHI ,  Kounosuke OISAKI ,  Yoichiro KUNINOBU

IPC: A61K31/69 ,  A61K31/4725 ,  C07F5/02 ,  C07D215/06 ,  C07D207/46 ,  C07D207/456 ,  A61K31/4025 ,  C07D401/14

CPC classification number: A61K31/69 ,  A61K31/4025 ,  A61K31/4725 ,  A61K41/00 ,  C07D207/44 ,  C07D207/456 ,  C07D207/46 ,  C07D215/06 ,  C07D401/14 ,  C07D455/04 ,  C07F5/02

Abstract: Provided are a compound which is useful as an in vivo applicable, amyloid-oxygenating catalyst selective for amyloid and applicable not only to an Aβ peptide but also to other amyloids and a drug containing the compound for preventing and/or treating amyloid-related-diseases.Disclosed is a boron-dipyrrin complex represented by the following formula (1) wherein X1 and X2 are the same or different and each represent a halogenoalkyl group or a halogen atom; R1 represents a hydrogen atom, an alkyl group, or a group represented by formula (b); R2 and R6 are the same or different and each represent a hydrogen atom or a halogen atom; R3, R4, R5, and R7 are the same or different and each represent a hydrogen atom, a halogen atom, or an alkyl group; R8 represents a hydrogen atom or —(CH2)l—(Y)m—(CH2)n—Z wherein Y represents —CO—, —CONH—, or a triazole ring, Z represents a carboxyl group, a sulfonic acid group, or a —CO-peptide residue, l and n each represent an integer of 1 to 6, and m represents 0 or 1; R9 and R10 are the same or different and each represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; and R8 and R10 together optionally form an alkylene group.

公开(公告)号：US20170197956A1

公开(公告)日：2017-07-13

申请号：US15326320

申请日：2015-07-15

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu KANAI ,  Yohei SOMA ,  Atsuhiko TANIGUCHI ,  Yusuke SHIMIZU

IPC: C07D455/04 ,  C07D417/04

CPC classification number: C07D455/04 ,  A61K31/4725 ,  A61K31/4745 ,  A61K38/00 ,  C07D417/04 ,  C07K7/06 ,  C07K14/47

Abstract: It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to Aβ peptides but to other amyloids; and a prophylactic or therapeutic drug for an amyloid-related disease, comprising the same. The present invention provides a benzothiazole compound represented by the following formula (1) wherein X represents a halogen atom; R1 represents an optionally substituted hydrocarbon group; R2 represents a hydrogen atom or an optionally substituted hydrocarbon group; R3 and R4 are the same or different and each represent a hydrogen atom, an optionally substituted hydrocarbon group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; R2 and R4 optionally together form an alkylene group; and R5 represents an anion.