公开(公告)号：US20170057943A1

公开(公告)日：2017-03-02

申请号：US15237763

申请日：2016-08-16

申请人： Japan Tobacco Inc.

发明人： Ikuo Mitani ,  Yutaro Hirono ,  Masaki Yamashita

IPC分类号： C07D401/04 ,  A61K31/53 ,  C07D251/22

CPC分类号： C07D401/04 ,  A61K31/53 ,  A61P19/02 ,  A61P27/06 ,  C07D251/22

摘要： The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and/or cancer including colorectal cancer.The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.

摘要翻译： 其中每个符号如说明书中所定义。

公开(公告)号：US20240116943A1

公开(公告)日：2024-04-11

申请号：US18124389

申请日：2023-03-21

申请人： Japan Tobacco Inc.

发明人： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka Yamaoka

IPC分类号： C07D491/048

CPC分类号： C07D491/048

摘要： The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like.




wherein each symbol is as defined in the description.

公开(公告)号：US20150266834A1

公开(公告)日：2015-09-24

申请号：US14626243

申请日：2015-02-19

申请人： Japan Tobacco Inc.

发明人： Hironobu Nagamori ,  Ikuo Mitani ,  Masaki Yamashita ,  Takahiro Hotta ,  Yuichi Nakagawa ,  Masatoshi Ueda

IPC分类号： C07D251/22 ,  A61K45/06 ,  A61K31/53

摘要： Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

摘要翻译： 提供具有mPGES-1抑制活性的化合物，其可用于预防或治疗疼痛，风湿病，骨关节炎，发烧，阿尔茨海默病，多发性硬化，动脉硬化，青光眼，眼高血压，缺血性视网膜疾病，系统性硬皮病和包括结肠直肠癌 癌症。 由式[I]表示的化合物或其药学上可接受的盐：其中每个符号如规范中所定义。

公开(公告)号：US20240076278A1

公开(公告)日：2024-03-07

申请号：US18114043

申请日：2023-02-24

申请人： Japan Tobacco Inc.

发明人： Ikuo Mitani ,  Yutaro Hirono ,  Masaki Yamashita

IPC分类号： C07D401/04 ,  A61K31/53 ,  A61P19/02 ,  A61P27/06 ,  C07D251/22

CPC分类号： C07D401/04 ,  A61K31/53 ,  A61P19/02 ,  A61P27/06 ,  C07D251/22

摘要： The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and/or cancer including colorectal cancer.
The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof:




wherein each symbol is as defined in the specification.

公开(公告)号：US11643417B2

公开(公告)日：2023-05-09

申请号：US17493528

申请日：2021-10-04

申请人： Japan Tobacco Inc.

发明人： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka Yamaoka

IPC分类号： C07D491/048 ,  C07D491/107 ,  C07D519/00 ,  A61K31/551 ,  A61P9/12 ,  A61P11/00 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D491/048

摘要： The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like.




wherein each symbol is as defined in the description.

公开(公告)号：US20210024486A1

公开(公告)日：2021-01-28

申请号：US16807719

申请日：2020-03-03

申请人： Japan Tobacco Inc.

发明人： Ikuo Mitani ,  Yutaro Hirono ,  Masaki Yamashita

IPC分类号： C07D401/04 ,  C07D251/22 ,  A61P27/06 ,  A61P19/02 ,  A61K31/53

摘要： The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and/or cancer including colorectal cancer.
The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.

公开(公告)号：US10752596B2

公开(公告)日：2020-08-25

申请号：US16150989

申请日：2018-10-03

申请人： JAPAN TOBACCO INC.

发明人： Hironobu Nagamori ,  Tatsuya Nishimaru ,  Masaki Takagi ,  Ikuo Mitani ,  Yuichi Nakagawa

IPC分类号： C07D241/12 ,  C07D213/46 ,  A61P19/06 ,  C07D405/10 ,  A61P43/00 ,  A61K31/4965 ,  C07D217/16 ,  A61K31/497 ,  C07D213/55 ,  A61K31/4433 ,  A61K31/4418 ,  C07D405/04 ,  A61K31/472

摘要： The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20200017492A1

公开(公告)日：2020-01-16

申请号：US16560156

申请日：2019-09-04

申请人： Japan Tobacco Inc.

发明人： Ikuo Mitani ,  Yosuke Ogoshi ,  Takuya Matsui ,  Masahiro Yokota ,  Masakazu Terashita ,  Dai Motoda ,  Kazuhito Ueyama ,  Hiroyuki Abe ,  Takahiro Hotta ,  Takashi Ito

IPC分类号： C07D471/04

摘要： The present invention provides a triazolopyridine compound having a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability. The present invention relates to a compound represented by the following formula [I]: wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as a prolyl hydroxylase inhibitor or erythropoietin production-inducing agent containing the compound. The compound of the present invention shows a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability and is useful as a prophylactic or therapeutic agent for various diseases and pathologies (disorders) caused by decreased production of erythropoietin.

公开(公告)号：US20230011968A1

公开(公告)日：2023-01-12

申请号：US17575931

申请日：2022-01-14

申请人： Japan Tobacco Inc.

发明人： Hironobu Nagamori ,  Ikuo Mitani ,  Masaki Yamashita ,  Takahiro Hotta ,  Yuichi Nakagawa ,  Masatoshi Ueda

IPC分类号： C07D251/22 ,  A61P27/06 ,  A61K31/53 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D405/12 ,  C07D471/10 ,  A61K45/06

摘要： Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.
A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

公开(公告)号：US20220162220A1

公开(公告)日：2022-05-26

申请号：US17493528

申请日：2021-10-04

申请人： Japan Tobacco Inc.

发明人： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka YAMAOKA

IPC分类号： C07D491/048

摘要： The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.