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    Artificial cornea
    1.
    发明授权
    Artificial cornea 失效
    人造角膜

    公开(公告)号：US06976997B2

    公开(公告)日：2005-12-20

    申请号：US10465040

    申请日：2003-06-18

    申请人： Jaan Noolandi ,  Christopher Ta ,  Philip Huie, Jr. ,  Alan J. Smith ,  Robert Waymouth ,  Mark Blumenkranz

    发明人： Jaan Noolandi ,  Christopher Ta ,  Philip Huie, Jr. ,  Alan J. Smith ,  Robert Waymouth ,  Mark Blumenkranz

    IPC分类号： A61L27/00 ,  A61F20060101 ,  A61F2/14 ,  A61F2/16 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56

    CPC分类号： B82Y30/00 ,  A61F2/142 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/432 ,  C08L89/06

    摘要： The invention provides implants suitable for use as an artificial cornea, and methods for making and using such implants. Artificial corneas having features of the invention may be two-phase artificial corneas, or may be three phase artificial corneas. These artificial corneas have a flexible, optically clear central core and a hydrophilic, porous skirt, both of which are biocompatible and allow for tissue integration. A three-phase artificial cornea will further have an interface region between the core and skirt. The artificial corneas have a high degree of ocular tolerance, and allow for tissue integration into the skirt and for epithelial cell growth over the surface of the prosthesis. The use of biocompatible material avoids the risk of disease transmission inherent with corneal transplants, and acts to minimize post-operative inflammation and so to reduce the chance or severity of tissue necrosis following implantation of the synthetic cornea onto a host eye.

    摘要翻译： 本发明提供适合用作人造角膜的植入物，以及制造和使用这种植入物的方法。 具有本发明特征的人造角膜可以是两相人造角膜，也可以是三相人造角膜。 这些人造角膜具有柔性的，光学透明的中心芯和亲水的，多孔的裙部，两者都是生物相容的并且允许组织整合。 三相人造角膜还将具有在芯部和裙部之间的界面区域。 人造角膜具有高度的眼部耐受性，并且允许组织整合到裙部中并且允许在假体表面上的上皮细胞生长。 生物相容材料的使用避免了角膜移植固有的疾病传播的风险，并且起作用以使术后炎症最小化，从而降低植入人工角膜后的组织坏死的机会或严重程度。

    Interpenetrating polymer network hydrogel corneal prosthesis
    3.
    发明授权
    Interpenetrating polymer network hydrogel corneal prosthesis 有权
    互穿聚合物网络水凝胶角膜假体

    公开(公告)号：US07909867B2

    公开(公告)日：2011-03-22

    申请号：US11639049

    申请日：2006-12-13

    申请人： David Myung ,  Christopher Ta ,  Curtis W. Frank ,  Won-Gun Koh ,  Jaan Noolandi

    发明人： David Myung ,  Christopher Ta ,  Curtis W. Frank ,  Won-Gun Koh ,  Jaan Noolandi

    IPC分类号： A61F2/14

    CPC分类号： C12N5/0621 ,  A61F2/142 ,  A61F2/15 ,  A61L27/00 ,  A61L27/26 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/214 ,  A61L2300/23 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2430/16 ,  C12N2533/30 ,  C12N2533/54 ,  C08L71/02 ,  C08L33/08

    摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.

    摘要翻译： 本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。 这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。 任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。 该材料设计用作角膜假体。

    Artificial cornea
    4.
    发明申请
    Artificial cornea 审中-公开
    人造角膜

    公开(公告)号：US20060287721A1

    公开(公告)日：2006-12-21

    申请号：US11409218

    申请日：2006-04-20

    申请人： David Myung ,  Christopher Ta ,  Nabeel Farooqui ,  Curtis Frank ,  Won-Gun Koh ,  Jungmin Ko ,  Jaan Noolandi ,  Michael Carrasco

    发明人： David Myung ,  Christopher Ta ,  Nabeel Farooqui ,  Curtis Frank ,  Won-Gun Koh ,  Jungmin Ko ,  Jaan Noolandi ,  Michael Carrasco

    IPC分类号： A61F2/14

    CPC分类号： A61F2/142 ,  A61F2/15 ,  A61K35/12

    摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.

    摘要翻译： 本发明提供了一种人造角膜植入物，其具有光学透明的中心纤芯和围绕中心纤芯的多孔，亲水的，生物相容的裙部。 在一个实施方案中，中心芯由互穿双网络水凝胶制成，裙部由聚（丙烯酸2-羟乙酯）（PHEA）制成。 在另一个实施例中，中心芯和裙部均由互穿双网络水凝胶制成。 人造角膜植入物也可以具有相互扩散区​​域，其中裙部组件与芯部件互穿，反之亦然。 在优选的实施方案中，生物分子连接到裙部，中心芯或两者。 这些生物分子可以是任何类型的生物分子，但优选支持上皮和/或成纤维细胞存活和生长的生物分子。 优选地，生物分子以空间选择性方式连接。 本发明还提供了使用光刻法制造人造角膜植入物的方法。

    Intraocular lens implant
    5.
    发明申请
    Intraocular lens implant 审中-公开
    人工晶状体植入物

    公开(公告)号：US20070233240A1

    公开(公告)日：2007-10-04

    申请号：US11725190

    申请日：2007-03-16

    申请人： Curtis Frank ,  Christopher Ta ,  David Myung ,  Jaan Noolandi ,  Michael Carrasco ,  Won-Gun Koh

    发明人： Curtis Frank ,  Christopher Ta ,  David Myung ,  Jaan Noolandi ,  Michael Carrasco ,  Won-Gun Koh

    IPC分类号： A61F2/16

    CPC分类号： A61K35/44 ,  A61F2/142 ,  A61F2/145 ,  A61L27/26 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3839 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/602 ,  A61L2430/16 ,  C12N5/0621 ,  C12N2533/30 ,  C08L33/08 ,  C08L71/02

    摘要： The present invention provides a hydrogel-based intraocular lens (IOL) implant that can covalently attach to a lens capsule on implantation into an eye. The inventive IOL has a high refractive index, high elasticity, and is of a similar size to a naturally occurring lens. In addition, the IOL can be implanted in a smaller, dehydrated state, allowing the IOL to be placed in the lens capsule with a small incision (up to about 1/10 the volume of the IOL). Exposure to fluid can then initiate rapid swelling of the dried polymer to the shape and dimensions of a natural lens, with full occupation of the lens capsule. Upon equilibrium swelling, the IOL can then make contact with the inner aspect of the lens capsule and covalently bind to it. By this attachment process, the IOL may accommodate in a manner identical to that of the natural lens.

    摘要翻译： 本发明提供一种水凝胶型眼内透镜（IOL）植入物，其可以植入眼睛中共价连接到晶状体囊。 本发明的IOL具有高折射率，高弹性，并且具有与天然存在的透镜相似的尺寸。 此外，IOL可以植入较小的脱水状态，允许IOL以小切口（高达IOL体积的约1/10）放置在晶状体囊中。 然后暴露于流体可以引发干燥的聚合物快速膨胀到天然晶状体的形状和尺寸，完全占据晶状体囊。 在平衡肿胀时，IOL然后可以与镜片胶囊的内部部分接触并共价结合。 通过该附接过程，IOL可以以与天然镜片相同的方式容纳。

    Interpenetrating polymer network hydrogel contact lenses
    6.
    发明申请
    Interpenetrating polymer network hydrogel contact lenses 有权
    互穿聚合物网络水凝胶隐形眼镜

    公开(公告)号：US20070126982A1

    公开(公告)日：2007-06-07

    申请号：US11636114

    申请日：2006-12-07

    申请人： David Myung ,  Jaan Noolandi ,  Christopher Ta ,  Curtis Frank

    发明人： David Myung ,  Jaan Noolandi ,  Christopher Ta ,  Curtis Frank

    IPC分类号： G02C7/04

    CPC分类号： G02B1/043 ,  C08L51/08

    摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.

    摘要翻译： 本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。 水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 遥爪大分子单体的分子量优选为约575Da至约20,000Da。 也可以使用分子量的混合物。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。 该材料被设计成用作隐形眼镜。

    Interpenetrating polymer network hydrogel corneal prosthesis
    7.
    发明申请
    Interpenetrating polymer network hydrogel corneal prosthesis 有权
    互穿聚合物网络水凝胶角膜假体

    公开(公告)号：US20070179605A1

    公开(公告)日：2007-08-02

    申请号：US11639049

    申请日：2006-12-13

    申请人： David Myung ,  Christopher Ta ,  Curtis Frank ,  Won-Gun Koh ,  Jaan Noolandi

    发明人： David Myung ,  Christopher Ta ,  Curtis Frank ,  Won-Gun Koh ,  Jaan Noolandi

    IPC分类号： A61F2/14 ,  C12N5/08

    CPC分类号： C12N5/0621 ,  A61F2/142 ,  A61F2/15 ,  A61L27/00 ,  A61L27/26 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/214 ,  A61L2300/23 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2430/16 ,  C12N2533/30 ,  C12N2533/54 ,  C08L71/02 ,  C08L33/08

    摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.

    摘要翻译： 本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。 这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。 任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。 该材料设计用作角膜假体。

    Interpenetrating polymer network hydrogel contact lenses
    9.
    发明授权
    Interpenetrating polymer network hydrogel contact lenses 有权
    互穿聚合物网络水凝胶隐形眼镜

    公开(公告)号：US07857447B2

    公开(公告)日：2010-12-28

    申请号：US11636114

    申请日：2006-12-07

    申请人： David Myung ,  Jaan Noolandl ,  Christopher Ta ,  Curtis W. Frank

    发明人： David Myung ,  Jaan Noolandl ,  Christopher Ta ,  Curtis W. Frank

    IPC分类号： G02H7/04

    CPC分类号： G02B1/043 ,  C08L51/08

    摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.

    摘要翻译： 本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。 水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 遥爪大分子单体的分子量优选为约575Da至约20,000Da。 也可以使用分子量的混合物。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。 该材料被设计成用作隐形眼镜。