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公开(公告)号：US20050124548A1
公开(公告)日：2005-06-09
申请号：US10764379
申请日：2004-01-23
CPC分类号： C07K7/06
摘要： Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8, and A9 are amino acyl residues as defined herein.
摘要翻译： 具有以下结构式的肽：<？in-line-formula description =“In-line Formulas”end =“lead”？> A 1 > 2 3→3→3→3→5→ - →3→ > 7 -A “end =”tail“？>其中A
选自氢或酰基; A 10是羟基或氨基酸酰胺; 和A 1，A 2，A 3，A 4，A 5， A 6，A 7，A 8和A 9是如本文所定义的氨基酰基残基。 -
公开(公告)号：US20070032527A1
公开(公告)日：2007-02-08
申请号：US11537714
申请日：2006-10-02
申请人： Fortuna Haviv , Michael Bradley , Jurgen Dinges , Daryl Sauer , Jack Henkin
发明人： Fortuna Haviv , Michael Bradley , Jurgen Dinges , Daryl Sauer , Jack Henkin
IPC分类号： A61K31/455
CPC分类号： A61K31/455
摘要： Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
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公开(公告)号：US20060030557A1
公开(公告)日：2006-02-09
申请号：US11244481
申请日：2005-10-06
申请人： Fortuna Haviv , Michael Bradley , Jack Henkin , Jurgen Dinges , Daryl Sauer , Lawrence Kolaczkowski , Anil Vasudevan , David Park
发明人： Fortuna Haviv , Michael Bradley , Jack Henkin , Jurgen Dinges , Daryl Sauer , Lawrence Kolaczkowski , Anil Vasudevan , David Park
IPC分类号： A61K31/551 , A61K31/541 , C07D417/02 , C07D403/02
CPC分类号： C07D213/81 , A61K31/4439 , A61K31/4545 , A61K31/4747 , A61K31/496 , A61K31/541 , A61K31/551 , C07D213/82 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D491/10
摘要： Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
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公开(公告)号：US07432245B2
公开(公告)日：2008-10-07
申请号：US10456831
申请日：2003-06-06
申请人： Fortuna Haviv , Bryan K. Erickson , Jack Henkin , Luk C. Li , Fanfeng Ma , Friedrich W. Richter , Yi Shi , Jingfeng Song , Siriporn Toongsuwan
发明人： Fortuna Haviv , Bryan K. Erickson , Jack Henkin , Luk C. Li , Fanfeng Ma , Friedrich W. Richter , Yi Shi , Jingfeng Song , Siriporn Toongsuwan
摘要： Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.
摘要翻译： 公开了可用于持续释放的肽的肠胃外制剂。 还公开了制剂的制备方法。
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公开(公告)号：US06753408B1
公开(公告)日：2004-06-22
申请号：US09718591
申请日：2000-11-22
IPC分类号： C07K700
CPC分类号： C07K7/06
摘要： Peptides of formula (I) Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11 (I), are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
摘要翻译： 式（I）的肽可用于抑制血管发生。 还公开了血管生成抑制组合物和抑制哺乳动物血管发生的方法。
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公开(公告)号：US06716963B1
公开(公告)日：2004-04-06
申请号：US09447226
申请日：1999-11-22
IPC分类号： C07K700
CPC分类号： C07K7/06
摘要： Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8, and A9 are amino acyl residues as defined herein.
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公开(公告)号：US06774211B1
公开(公告)日：2004-08-10
申请号：US09833196
申请日：2001-04-11
IPC分类号： C07K700
CPC分类号： C07K7/06
摘要： Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8, and A9 are amino acyl residues as defined herein.
摘要翻译： 具有下式的肽：其中A0选自氢或酰基; A10是羟基或氨基酰胺; 并且A1，A2，A3，A4，A5，A6，A7，A8和A9是如本文所定义的氨基酰基残基。
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公开(公告)号：US06777535B1
公开(公告)日：2004-08-17
申请号：US09703233
申请日：2000-10-31
IPC分类号： C07K700
摘要： N-Alkylated peptides of formula (I) Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11 (I), are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
摘要翻译： 式（I）的N-烷基化肽可用于抑制血管发生。 还公开了血管生成抑制组合物和抑制哺乳动物血管发生的方法。
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9.发明申请TETRA-, PENTA-, HEXA- AND HEPTAPEPTIDES HAVING ANTIANGIOGENIC ACTIVITY 审中-公开具有抗炎活性的TETRA-，PENTA-，HEXA-和HEPTAPEPTID公开(公告)号：US20080071062A1
公开(公告)日：2008-03-20
申请号：US11620825
申请日：2007-01-08
申请人： Fortuna Haviv , Michael Bradley
发明人： Fortuna Haviv , Michael Bradley
IPC分类号： C07K16/00
摘要： Compounds of formula (SEQ ID NO:2) and (SEQ ID NO:3), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
摘要翻译： 描述了可用于治疗由血管生成引起或加重的病症的式（SEQ ID NO：2）和（SEQ ID NO：3）的化合物。 还公开了包含这些化合物的药物组合物，使用这些化合物的治疗方法，以及抑制血管发生的方法。
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公开(公告)号：US20070167376A1
公开(公告)日：2007-07-19
申请号：US11460123
申请日：2006-07-26
申请人： Fortuna Haviv , Michael Bradley
发明人： Fortuna Haviv , Michael Bradley
摘要： Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
摘要翻译： 描述了可用于治疗由血管生成引起或加剧的病症的式（SEQ ID NO：1）的化合物。 还公开了包含这些化合物的药物组合物，使用这些化合物的治疗方法，以及抑制血管发生的方法。
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