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公开(公告)号：US08722323B2
公开(公告)日：2014-05-13
申请号：US12917661
申请日：2010-11-02
申请人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： C12Q1/00
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US20110124116A1
公开(公告)日：2011-05-26
申请号：US12917661
申请日：2010-11-02
申请人： Jacob N. WOHLSTADTER , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. WOHLSTADTER , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N21/76
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US07015046B2
公开(公告)日：2006-03-21
申请号：US10693441
申请日：2003-10-24
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N21/76
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
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公开(公告)号：US07824925B2
公开(公告)日：2010-11-02
申请号：US11264535
申请日：2005-10-31
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N33/551 , G01N33/553
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多种具体的测试程序。
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公开(公告)号：US06673533B1
公开(公告)日：2004-01-06
申请号：US08932110
申请日：1997-09-17
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N33543
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US06413783B1
公开(公告)日：2002-07-02
申请号：US08932985
申请日：1997-09-18
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
IPC分类号： G01N33543
CPC分类号： G01N33/5438 , G01N21/76 , G01N33/5302 , Y10S435/808 , Y10S436/805
摘要： An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.
摘要翻译： 测定装置包括具有工作电极的单元和在该单元结构上耦合以超声处理单元的内容的超声处理设备。
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公开(公告)号：US07008796B2
公开(公告)日：2006-03-07
申请号：US10152234
申请日：2002-05-21
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , G01N21/76 , G01N33/5302 , Y10S435/808 , Y10S436/805
摘要： An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.
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公开(公告)号：US20060068499A1
公开(公告)日：2006-03-30
申请号：US11264535
申请日：2005-10-31
申请人： Jacob Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark Billadeau , Larry Helms , Ramin Darvari
发明人： Jacob Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark Billadeau , Larry Helms , Ramin Darvari
IPC分类号： G01N21/76
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
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9.发明申请公开(公告)号：US20100009007A1
公开(公告)日：2010-01-14
申请号：US12170792
申请日：2008-07-10
IPC分类号： A61K9/14
CPC分类号： A61K9/5052 , A61K9/5073
摘要： The present disclosure is directed to surface-modified microparticles, pharmaceutical compositions thereof, and methods of making and using such particles. The surface-modified microparticles include a microparticle core, and at least one monolayer associated with the microparticle core. The monolayer comprises an amphiphilic polymer or non-ionic polymer grafted to an ionic polymer.
摘要翻译： 本公开涉及表面改性的微粒，其药物组合物，以及制备和使用这些颗粒的方法。 表面改性微粒包括微粒核和与微粒核相关的至少一个单层。 单层包含接枝到离子聚合物上的两亲聚合物或非离子聚合物。
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10.发明申请公开(公告)号：US20050142205A1
公开(公告)日：2005-06-30
申请号：US10894410
申请日：2004-07-19
申请人： Julia Rashba-Step , Ramin Darvari , Terrence Scott
发明人： Julia Rashba-Step , Ramin Darvari , Terrence Scott
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/1647 , A61K9/1688 , A61K9/1694
摘要： The present invention relates to methods of making and compositions of microencapsulated small particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is then subjected to a liquid-solid phase separation to cause the active agent to form solid spherical small particles in the solid phase while the PSEA and solvent comprising the liquid phase. The spherical small particles formed are then microencapsulated within a polymeric matrix using an emulsion/evaporation process.
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