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    Primary human hepatocytes for native hepatitis C virus (HCV) replication
    3.
    发明申请
    Primary human hepatocytes for native hepatitis C virus (HCV) replication 审中-公开
    原生人肝细胞用于天然丙型肝炎病毒（HCV）复制

    公开(公告)号：US20060183111A1

    公开(公告)日：2006-08-17

    申请号：US11334392

    申请日：2006-01-19

    申请人： Ajit Kumar ,  Krishna Banaudha

    发明人： Ajit Kumar ,  Krishna Banaudha

    IPC分类号： C12Q1/70 ,  C12N5/08

    CPC分类号： C12N7/00 ,  C12N2770/24251

    摘要： Novel methods are disclosed for the long-term culture of human primary hepatocytes in tissue culture system. This culture system supports the replication, gene expression and dissemination of a multitude of pathogenic agents that reside in, or pass through, the liver. Among these, the invention advantageously provides for efficient hepatitis C virus (HCV) replication, and dissemination. Additionally disclosed are methods for the determining cellular receptors, hepatocyte cell subtypes, and host cell molecules required for efficient hepatic pathogen replication, expression and dissemination.

    摘要翻译： 公开了组织培养系统中人原代肝细胞长期培养的新方法。 该培养系统支持多种病原体的复制，基因表达和传播，其存在于肝脏或通过肝脏。 其中，本发明有利地提供有效的丙型肝炎病毒（HCV）复制和传播。 另外公开了确定有效的肝病原体复制，表达和传播所需的细胞受体，肝细胞细胞亚型和宿主细胞分子的方法。

    Manufacture of alkyl benzene sulphonic acids
    4.
    发明申请
    Manufacture of alkyl benzene sulphonic acids 审中-公开
    烷基苯磺酸的制造

    公开(公告)号：US20050152866A1

    公开(公告)日：2005-07-14

    申请号：US10492389

    申请日：2002-09-25

    申请人： Hendrick Frick ,  Ajit Kumar ,  Lean-Luc Urbain ,  Didier Hauss ,  Pierre Solastiouk

    发明人： Hendrick Frick ,  Ajit Kumar ,  Lean-Luc Urbain ,  Didier Hauss ,  Pierre Solastiouk

    IPC分类号： C07C303/42 ,  C07C303/02 ,  C07C303/44 ,  C07C309/30 ,  C07C309/31 ,  A61K7/075 ,  A61K31/185

    CPC分类号： C07C309/31 ,  C07C303/44 ,  C07C309/30

    摘要： A novel, storage-stable, free-flowing, solid product consisting essentially of an alkyl benzene sulphonic acid having 1 to 4 aliphatic carbon atoms and from 7 to 11% water based on the weight of the product, said alkyl benzene sulphonic acid comprising at least 90% by weight of a single isomer based on the total weight of organic material in the product, is prepared by drying a storage-unstable, solid alkyl benzene sulphonic acid having more than 11% by weight water, said drying being effected at sub atmospheric pressure and at a temperature below the softening point of the product.

    摘要翻译： 一种基于产物重量的基本上由具有1至4个脂族碳原子的烷基苯磺酸和7至11％水组成的新型储存稳定的自由流动的固体产物，所述烷基苯磺酸包含 通过干燥具有超过11重量％水的储存不稳定的固体烷基苯磺酸制备基于产物中有机材料总重量的单一异构体的至少90重量％，所述干燥在亚 大气压力和低于产品软化点的温度。

    Peeling Apparatus with Rotating Brush and Related Methods
    5.
    发明申请
    Peeling Apparatus with Rotating Brush and Related Methods 审中-公开
    带旋转刷的剥皮装置及相关方法

    公开(公告)号：US20140017373A1

    公开(公告)日：2014-01-16

    申请号：US13939601

    申请日：2013-07-11

    申请人： Ajit Kumar

    发明人： Ajit Kumar

    IPC分类号： A47J17/20 ,  A47J17/02

    CPC分类号： A47J17/20 ,  A47J17/02

    摘要： A peeling apparatus and related methods of peeling a food product are provided. The peeling apparatus includes a handle and a peeling blade connected to a first end of the handle. A rotatable brush is positioned proximate to the peeling blade, wherein the rotatable brush is rotatable about an elongated central axis, and wherein the elongated central axis is substantially parallel to a length of the peeling blade.

    摘要翻译： 提供剥皮装置和相关的食品剥离方法。 剥皮装置包括手柄和连接到手柄的第一端的剥离刀片。 可旋转的刷子定位成靠近剥离刀片，其中可旋转的刷子可以围绕细长的中心轴线旋转，并且其中细长的中心轴线基本上平行于剥皮刀片的长度。

    Fabricated Stone Apparatus and Method of Constructing the Same
    6.
    发明申请
    Fabricated Stone Apparatus and Method of Constructing the Same 有权
    制造石器具及其构造方法

    公开(公告)号：US20130333308A1

    公开(公告)日：2013-12-19

    申请号：US13921332

    申请日：2013-06-19

    申请人： Ajit Kumar

    发明人： Ajit Kumar

    IPC分类号： E04B1/04

    CPC分类号： E04B1/04 ,  E04C3/20 ,  E04C3/34 ,  Y10T29/49947

    摘要： A fabricated stone apparatus is provided. A plurality of stone sheets are affixed together to form a fabricated stone structure having a substantially hollow interior portion, wherein each of the plurality of stone sheets is substantially planar, and wherein a side edge of one of the plurality of stone sheets engages with a side edge of another of the plurality of stone sheets. A cover plate is positioned at an end of the fabricated stone structure, wherein the cover plate is connected to a top edge of at least a portion of the plurality of stone sheets, wherein the top edge is positioned substantially perpendicular to at least one of the side edges. At least one fastener is connected between at least two of the plurality of stone sheets, wherein the at least one fastener is positioned remotely from the cover plate.

    摘要翻译： 提供了一种装饰石装置。 将多个石材片固定在一起，形成具有大致中空的内部部分的制造的石材结构，其中，所述多个石材片中的每一个基本上是平面的，并且其中所述多个石板中的一个的侧边缘与侧面 多个石板中另一个的边缘。 盖板位于制造的石材结构的端部，其中盖板连接到多个石板的至少一部分的顶部边缘，其中顶部边缘基本上垂直于至少一个 侧边缘。 至少一个紧固件连接在多个石板中的至少两个之间，其中至少一个紧固件远离盖板定位。

    Fabricated Apparatus and Method of Constructing the Same
    8.
    发明申请
    Fabricated Apparatus and Method of Constructing the Same 审中-公开
    制造装置及其构造方法

    公开(公告)号：US20150204100A1

    公开(公告)日：2015-07-23

    申请号：US14676377

    申请日：2015-04-01

    申请人： Ajit Kumar

    发明人： Ajit Kumar

    IPC分类号： E04H12/04 ,  E04H12/34 ,  E04H12/00

    CPC分类号： E04C3/34 ,  E04B2103/02 ,  E04B2103/04 ,  E04C3/20 ,  Y10T29/49947

    摘要： A fabricated apparatus is provided. A plurality of sheets are affixed together to form a fabricated structure having a substantially hollow interior portion, wherein each of the plurality of sheets is substantially planar, and wherein a side edge of one of the plurality of sheets engages with a side edge of another of the plurality of sheets. A cover plate is positioned at an end of the fabricated structure, wherein the cover plate is connected to a top edge of at least a portion of the plurality of sheets, wherein the top edge is positioned substantially perpendicular to at least one of the side edges. At least one fastener is connected between at least two of the plurality of sheets, wherein the at least one fastener is positioned remotely from the cover plate.

    摘要翻译： 提供了一种制造的装置。 多个片材被固定在一起以形成具有基本上中空的内部部分的制造结构，其中多个片材中的每一个基本上是平面的，并且其中多个片材中的一个的侧边缘与另一个片材的侧边缘接合 多张纸。 盖板位于制造结构的端部，其中盖板连接到多个片材的至少一部分的顶部边缘，其中顶部边缘基本上垂直于至少一个侧边缘 。 至少一个紧固件连接在多个片材中的至少两个片材之间，其中至少一个紧固件远离盖板定位。

    Fabricated stone apparatus and method of constructing the same
    9.
    发明授权
    Fabricated stone apparatus and method of constructing the same 有权
    制造石器具及其构造方法

    公开(公告)号：US09016006B2

    公开(公告)日：2015-04-28

    申请号：US13921332

    申请日：2013-06-19

    申请人： Ajit Kumar

    发明人： Ajit Kumar

    IPC分类号： E02D5/74 ,  E04B1/04

    CPC分类号： E04B1/04 ,  E04C3/20 ,  E04C3/34 ,  Y10T29/49947

    摘要： A fabricated stone apparatus is provided. A plurality of stone sheets are affixed together to form a fabricated stone structure having a substantially hollow interior portion, wherein each of the plurality of stone sheets is substantially planar, and wherein a side edge of one of the plurality of stone sheets engages with a side edge of another of the plurality of stone sheets. A cover plate is positioned at an end of the fabricated stone structure, wherein the cover plate is connected to a top edge of at least a portion of the plurality of stone sheets, wherein the top edge is positioned substantially perpendicular to at least one of the side edges. At least one fastener is connected between at least two of the plurality of stone sheets, wherein the at least one fastener is positioned remotely from the cover plate.

    摘要翻译： 提供了一种装饰石装置。 将多个石材片固定在一起，形成具有大致中空的内部部分的制造的石材结构，其中，所述多个石材片中的每一个基本上是平面的，并且其中所述多个石板中的一个的侧边缘与侧面 多个石板中另一个的边缘。 盖板位于制造的石材结构的端部，其中盖板连接到多个石板的至少一部分的顶部边缘，其中顶部边缘基本上垂直于至少一个 侧边缘。 至少一个紧固件连接在多个石板中的至少两个之间，其中至少一个紧固件远离盖板定位。

    Molecular method to augment RNA mediated gene silencing
    10.
    发明申请
    Molecular method to augment RNA mediated gene silencing 审中-公开
    扩增RNA介导的基因沉默的分子方法

    公开(公告)号：US20060189560A1

    公开(公告)日：2006-08-24

    申请号：US11340561

    申请日：2006-01-27

    申请人： Ajit Kumar

    发明人： Ajit Kumar

    IPC分类号： A61K48/00 ,  C12N15/87

    CPC分类号： C12N15/111 ,  C07K14/4702 ,  C12N2310/14 ,  C12N2320/50

    摘要： The invention provides for a novel method of augmenting gene silencing via RNA interference (RNAi). Under the invention, RNAi technology is combined with the action of a variant nuclear factor to potently inhibit gene expression. In one embodiment of the invention, the nuclear factor is a variant of a double-stranded RNA (dsRNA) binding protein termed NF90ctv. The invention is also related to diagnostic/investigative and treatment methods and to cell lines produced by the methods disclosed.

    摘要翻译： 本发明提供了通过RNA干扰（RNAi）增强基因沉默的新方法。 根据本发明，RNAi技术与变异核因子的作用相结合，有效抑制基因表达。 在本发明的一个实施方案中，核因子是称为NF90ctv的双链RNA（dsRNA）结合蛋白的变体。 本发明还涉及诊断/调查和治疗方法以及通过所公开的方法产生的细胞系。