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1.发明申请公开(公告)号：US20120045819A1
公开(公告)日：2012-02-23
申请号：US13243761
申请日：2011-09-23
Applicant: Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
IPC: C12N7/01 , C07K14/755 , C07K7/08 , C07K7/06
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
Abstract translation: 本发明的目的是为因子VIII和因子VIII样蛋白提供新的结合分子。 本发明优选的结合分子不仅显示了靶因子VIII多肽的结合的明显特征，而且还显示了靶多肽的释放（洗脱）的特异性和期望特征。 根据本发明的特别优选的结合分子是短多肽序列，其特征在于稳定的环结构。
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2.发明授权公开(公告)号：US07691565B2
公开(公告)日：2010-04-06
申请号：US11345031
申请日：2006-01-31
Applicant: Jinan Yu , M. Daniel Potter , Marilous Potter, legal representative , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
IPC: C12Q1/70
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
Abstract translation: 本发明的目的是为因子VIII和因子VIII样蛋白提供新的结合分子。 本发明优选的结合分子不仅显示了靶因子VIII多肽的结合的明显特征，而且还显示了靶多肽的释放（洗脱）的特异性和期望特征。 根据本发明的特别优选的结合分子是短多肽序列，其特征在于稳定的环结构。
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公开(公告)号：US07112438B2
公开(公告)日：2006-09-26
申请号：US10272497
申请日：2002-10-15
Applicant: Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
IPC: G01N33/53
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
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公开(公告)号：US20060193829A1
公开(公告)日：2006-08-31
申请号：US11345031
申请日：2006-01-31
Applicant: Jinan Yu , M. Potter , Brian Kelley , Jeffrey Deetz , James Booth , Marilous Potter
Inventor： Jinan Yu , M. Potter , Brian Kelley , Jeffrey Deetz , James Booth , Marilous Potter
IPC: C07K7/06
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
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Patent Agency Ranking
5.发明授权公开(公告)号：US06492105B2
公开(公告)日：2002-12-10
申请号：US09756594
申请日：2001-01-08
Applicant: Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James Edward Booth
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James Edward Booth
IPC: C12Q170
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/001
Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
Abstract translation: 公开了用于检测人类因子VIII或因子VIII样多肽并将其从溶液如血液或条件培养基中分离出来的方法，连同适用于包含识别人因子VIII和/或Ⅷ因子的结合部分的目的的试剂 多肽，并与其形成结合复合物。 优选的多肽结合部分被特别公开。
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公开(公告)号：US08535892B2
公开(公告)日：2013-09-17
申请号：US13243761
申请日：2011-09-23
Applicant: Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
IPC: G01N33/53
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
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7.发明申请公开(公告)号：US20100292440A1
公开(公告)日：2010-11-18
申请号：US12692353
申请日：2010-01-22
Applicant: Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth , Marilous Potter
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth , Marilous Potter
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
Abstract translation: 本发明的目的是为因子VIII和因子VIII样蛋白提供新的结合分子。 本发明优选的结合分子不仅显示了靶因子VIII多肽的结合的明显特征，而且还显示了靶多肽的释放（洗脱）的特异性和期望特征。 根据本发明的特别优选的结合分子是短多肽序列，其特征在于稳定的环结构。
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8.发明授权Polypeptides for binding human factor VIII and fragments of human factor VIII 有权用于结合人因子VIII和人因子VIII片段的多肽公开(公告)号：US06197526B1
公开(公告)日：2001-03-06
申请号：US09224785
申请日：1999-01-04
Applicant: Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James Edward Booth
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James Edward Booth
IPC: G01N3353
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/001
Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
Abstract translation: 公开了用于检测人类因子VIII或因子VIII样多肽并将其从溶液如血液或条件培养基中分离出来的方法，连同适用于包含识别人因子VIII和/或Ⅷ因子的结合部分的目的的试剂 多肽，并与其形成结合复合物。 优选的多肽结合部分被特别公开。
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9.发明授权Methods and compositions for purifying human factor VIII, factor VIII-like proteins or fragments thereof 有权用于纯化人因子VIII，因子VIII样蛋白或其片段的方法和组合物公开(公告)号：US08058017B2
公开(公告)日：2011-11-15
申请号：US12692353
申请日：2010-01-22
Applicant: Jinan Yu , M. Daniel Potter , Marilous Potter, legal representative , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
Inventor： Jinan Yu , M. Daniel Potter , Brian D. Kelley , Jeffrey S. Deetz , James E. Booth
IPC: G01N33/53
CPC classification number: C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
Abstract: Provided herein are methods and compositions for purifying human factor VIII, human factor VIII-like peptide or fragments thereof. The methods comprise immobilizing a binding molecule for human factor VIII, human factor VIII-like protein or fragments thereof to a solid support, contacting the immobilized binding molecule with a solution containing the human factor VIII, human factor VIII-like protein or fragments thereof, and purifying the factor by separating the solution from the solid support.
Abstract translation: 本文提供了用于纯化人因子VIII，人因子VIII样肽或其片段的方法和组合物。 所述方法包括将人因子VIII，人因子VIII样蛋白或其片段的结合分子固定在固体支持物上，使固定的结合分子与含有人因子VIII，人因子VIII样蛋白或其片段的溶液接触， 并通过将溶液与固体支持物分离来纯化该因子。
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