公开(公告)号：US20060063717A1

公开(公告)日：2006-03-23

申请号：US11254971

申请日：2005-10-21

Applicant: James Boyd ,  David Singleton

Inventor： James Boyd ,  David Singleton

IPC: A61K38/08 ,  C07K7/06

CPC classification number: C07K7/02 ,  A61K38/00 ,  C07K5/0819

Abstract: This invention relates to a novel inhibitor of beta amyloid cleavage enzyme (BACE, transmembrane aspartyl protease beta-secretase, beta site APP cleavage enzyme, memapsin-2, BACE-1), pharmaceutical compositions containing it and its use in the treatment of neurological disorders such as Alzheimer's disease, Crutzfield-Jacob's disease, prion disorders, amyotrophic lateral sclerosis, progressive supranuclear palsy, head trauma, stroke, down's syndrome, pancreatitis, inclusion body myocitis, other peripheral amyloidoses and diabetes.

Abstract translation: 本发明涉及β淀粉样蛋白切割酶（BACE，跨膜天冬氨酰蛋白酶β-分泌酶，β位点APP裂解酶，memapsin-2，BACE-1）的新型抑制剂，含有它的药物组合物及其用于治疗神经障碍 例如阿尔茨海默氏病，克鲁兹菲 - 雅各布氏病，朊病毒病，肌萎缩性侧索硬化，进行性核上性麻痹，头部创伤，中风，下降综合征，胰腺炎，包涵体肌炎，其他外周淀粉样变性和糖尿病。

公开(公告)号：US09911133B1

公开(公告)日：2018-03-06

申请号：US13436925

申请日：2012-03-31

Applicant: Andrew David Walbran ,  Kenneth Paul Stoltz ,  David Singleton ,  Douglas Alexander Gresham

Inventor： Andrew David Walbran ,  Kenneth Paul Stoltz ,  David Singleton ,  Douglas Alexander Gresham

IPC: G06Q30/00 ,  G06Q30/02

CPC classification number: G06Q30/0226

Abstract: Systems and methods are described herein for supporting loyalty tiers. According to certain aspects, a custom number of loyalty tiers may be specified. Dynamic tier boundaries may be defined for each tier based upon a specified number of loyalty points, a percentile of total loyalty points, or a combination thereof. Periodic recomputing of tier boundary values can support dynamic loyalty tiers. According to certain other aspects, a user loyalty status may include a current tier and a pending tier. User loyalty points may be updated for a current loyalty activity. The updated user loyalty points may be compared with a point boundary for the pending tier and the user may be updated to the pending tier. Transacting the tier update with the server may be bypassed to reduce tier update latency. Also, immediate access at the client to features associated with the updated current tier may be supported.

公开(公告)号：US08667425B1

公开(公告)日：2014-03-04

申请号：US13249617

申请日：2011-09-30

Applicant: David Burke ,  Steven J. Lee ,  David Singleton

Inventor： David Burke ,  Steven J. Lee ,  David Singleton

IPC: G06F3/033

CPC classification number: G06F3/03547 ,  G06F3/04845 ,  G06F3/04883

Abstract: This disclosure is directed to techniques for presenting a scratch-card style interface using a touch-sensitive device. The touch-sensitive device is configured to present a first image using a display of the device. The first image may include a plurality of portions. The plurality of portions may be a plurality of overlapping image particles, or may be a plurality of image layers. The device may detect a first user interaction, and graphically remove a first number of portions of the first image in response to detection of the first user interaction. The device may detect a second user interaction, and graphically remove a second number of portions of the first image in response to the detected second user interaction. Graphical removal of the second number of portions may at least partially reveal a second image presented using the display of the device.

Abstract translation: 本公开涉及使用触敏设备呈现刮刮卡式接口的技术。 触敏设备被配置为使用设备的显示来呈现第一图像。 第一图像可以包括多个部分。 多个部分可以是多个重叠图像粒子，或者可以是多个图像层。 设备可以检测第一用户交互，并且响应于第一用户交互的检测而图形地移除第一图像的第一数量的部分。 设备可以检测第二用户交互，并且响应于检测到的第二用户交互而图形地移除第一图像的第二数量的部分。 图形地移除第二数量的部分可以至少部分地显示使用设备的显示呈现的第二图像。

公开(公告)号：US20130124306A1

公开(公告)日：2013-05-16

申请号：US13295804

申请日：2011-11-14

Applicant: Martin Hutchinson ,  David Singleton

Inventor： Martin Hutchinson ,  David Singleton

IPC: G06Q30/02

CPC classification number: G06Q30/02

Abstract: A voucher verification system is based on SMS message-based processing of voucher verifications by a central verification authority. Merchants may establish an account with the system and then register mobile communication devices and those of employees by sending an SMS-based registration request to the system. Once registered, the merchant and employees may verify the status of vouchers by sending SMS-base verification requests to the system. Verifications of voucher status are returned to the merchant mobile device via SMS messaging.

Abstract translation: 凭证验证系统基于中央验证机构基于SMS消息处理凭证验证。 商户可以与系统建立账户，然后通过向系统发送基于SMS的注册请求来注册移动通信设备和员工。 一旦注册，商家和员工可以通过向系统发送SMS基础验证请求来验证凭证的状态。 凭证状态的验证将通过SMS消息传递给商家移动设备。

公开(公告)号：US20070219112A1

公开(公告)日：2007-09-20

申请号：US11748976

申请日：2007-05-15

Applicant: David Singleton ,  Louis Kravetz ,  Brendan Murray

Inventor： David Singleton ,  Louis Kravetz ,  Brendan Murray

IPC: C11D3/20

CPC classification number: C11D1/72 ,  C11D1/146

Abstract: There is provided a new branched primary alcohol composition and the sulfates thereof exhibiting good cold water detergency and biodegradability. The branched primary alcohol composition has an average number of branches per chain of at least 0.7, having at least 8 carbon atoms and contianing both methyl and ethyl branches. The primary alcohol composition may also contain less than 0.5 atom % of quaternary carbon atoms, and a significant number ethyl branches, terminal isopropyl branches, and branching at the C3 position relative to the hydroxyl carbon. The process for its manufacture is by skeletally isomerizing an olefin feed having at least 7 carbon atoms followed by conversion to an alcohol, as by way of hydroformylation, and ultimately, sulfation to obtain a detergent surfactant. Useful catalysts include the zeolites having at least one channel with a crystallographic free diameter along the x and/or y planes of the [001] view ranging from greater than 4.2 Å and less than 7 Å but allows one to skeletally isomerize the olefin to produce a variety of branches, while retaining ready biodegradability and good cold water detergency.

Abstract translation: 提供了一种新的支链伯醇组合物，其硫酸盐具有良好的冷水去污力和生物降解性。 支链伯醇组合物具有至少0.7个链的平均支链数，至少为0.7，具有至少8个碳原子并连接甲基和乙基支链。 伯醇组合物还可以含有小于0.5原子％的季碳原子，相对于羟基碳，在C 3位上有大量的乙基支链，末端异丙基支链和支链。 其制造方法是通过骨架异构化具有至少7个碳原子的烯烃原料，然后转化为醇，通过加氢甲酰化，最终硫酸化得到洗涤剂表面活性剂。 有用的催化剂包括沿[001]视图的x和/或y平面具有至少一个具有至少一个具有结晶自由直径的通道的沸石，范围从大于4.2和小于7，但允许一个骨架异构化烯烃以产生 各种分支，同时保持即时的生物降解性和良好的冷水去污力。

公开(公告)号：US20140256357A1

公开(公告)日：2014-09-11

申请号：US13842088

申请日：2013-03-15

Applicant: Ray Xiaohang Wang ,  Farhan Shamsi ,  Yakov Okshtein ,  David Singleton ,  Douglas Alexander Gresham ,  Alan Newberger ,  Lixin Zhang

Inventor： Ray Xiaohang Wang ,  Farhan Shamsi ,  Yakov Okshtein ,  David Singleton ,  Douglas Alexander Gresham ,  Alan Newberger ,  Lixin Zhang

IPC: H04W4/02

CPC classification number: H04W4/027 ,  G01C21/00 ,  G01C21/3679 ,  H04L67/26 ,  H04W4/02 ,  H04W4/021 ,  H04W4/022 ,  H04W4/029 ,  H04W4/20 ,  H04W4/21

Abstract: Receiving point of interest zones and alerts on user devices comprises communicating, by a user computing device to a remote computing device, a request for point of interest data corresponding to points of interest within a proximity of the user device; presenting the received point of interest data; identifying a particular point of interest; and outputting an alert regarding the particular point of interest. Receiving point of interest zones on user devices comprises communicating a request for point of interest data; receiving the point of interest data from the remote network device wherein a size of the point of interest zone is determined based on a density of points of interest in the proximity of the user, and wherein the shape of the point of interest zone is expanded in a direction of travel and contracted in the opposite direction; and presenting the received point of interest data.

Abstract translation: 在用户设备上接收兴趣点区域和警报包括由用户计算设备向远程计算设备通知与用户设备附近的兴趣点对应的兴趣点数据的请求; 呈现接收的兴趣点数据; 识别一个特定的兴趣点; 并输出关于特定兴趣点的警报。 在用户设备上接收兴趣点区域包括传送关于兴趣点数据的请求; 从所述远程网络设备接收所述兴趣点数据，其中，基于所述用户附近的兴趣点的密度来确定所述兴趣点区域的大小，并且其中所述兴趣点区域的形状在 旅行方向与方向相反; 并呈现所接收的兴趣点数据。

公开(公告)号：US08332500B1

公开(公告)日：2012-12-11

申请号：US12697007

申请日：2010-01-29

Applicant: David Singleton ,  Scott Eblen ,  Adam Connors

Inventor： David Singleton ,  Scott Eblen ,  Adam Connors

IPC: G06F15/173

CPC classification number: G06Q10/10

Abstract: In general, this disclosure describes example techniques to transmit a request for data for one or more applications based on usage patterns of the one or more applications by a user. A device such as, but not limited to, a mobile device may monitor usage characteristics of the one or more applications. The device may transmit a request for data used by the one or more applications executed on the device based on the monitored usage characteristics.

Abstract translation: 通常，本公开描述了基于用户对一个或多个应用的​​使用模式来发送针对一个或多个应用的​​数据请求的示例技术。 诸如但不限于移动设备的设备可以监视一个或多个应用的​​使用特性。 该设备可以基于所监视的使用特征来传送由设备上执行的一个或多个应用使用的数据的请求。

公开(公告)号：US20090228281A1

公开(公告)日：2009-09-10

申请号：US12044310

申请日：2008-03-07

Applicant: David Singleton ,  Debajit Ghosh

Inventor： David Singleton ,  Debajit Ghosh

IPC: G10L21/00

CPC classification number: G10L15/08 ,  G01C21/3608 ,  G06F17/30241 ,  G06F17/30477 ,  G06F17/30554 ,  G10L15/065 ,  G10L15/19 ,  G10L15/22 ,  G10L2015/223 ,  G10L2015/228

Abstract: The subject matter of this specification can be embodied in, among other things, a method that includes receiving geographical information derived from a non-verbal user action associated with a first computing device. The non-verbal user action implies an interest of a user in a geographic location. The method also includes identifying a grammar associated with the geographic location using the derived geographical information and outputting a grammar indicator for use in selecting the identified grammar for voice recognition processing of vocal input from the user.

Abstract translation: 本说明书的主题可以包括接收从与第一计算设备相关联的非语言用户动作导出的地理信息的方法。 非语言用户操作意味着用户在地理位置中的兴趣。 该方法还包括使用导出的地理信息来识别与地理位置相关联的语法，并且输出用于选择用于从用户进行的声音输入的语音识别处理的所识别的语法的语法指示符。

公开(公告)号：US09147001B1

公开(公告)日：2015-09-29

申请号：US13586804

申请日：2012-08-15

Applicant: Brian Brewington ,  Gregory Michael Blevins ,  Guang Yang ,  Dale Hawkins ,  Tushar Udeshi ,  Steve Okamoto ,  Andrew Kirmse ,  Gokay Baris Gultekin ,  Emil Praun ,  Thomas Carl Stamm ,  David Singleton ,  James A. Guggemos ,  Pablo Bellver ,  Keir Mierle ,  Erez Louider

Inventor： Brian Brewington ,  Gregory Michael Blevins ,  Guang Yang ,  Dale Hawkins ,  Tushar Udeshi ,  Steve Okamoto ,  Andrew Kirmse ,  Gokay Baris Gultekin ,  Emil Praun ,  Thomas Carl Stamm ,  David Singleton ,  James A. Guggemos ,  Pablo Bellver ,  Keir Mierle ,  Erez Louider

IPC: G06F17/30

CPC classification number: G06F17/3087

Abstract: Computer-implemented methods for generating and executing user-based standing queries are provided. In one aspect, a method includes determining whether to generate a notification based on a user-based query and geographical context. The method also includes filtering the notification through explicit or inferred filter criteria. Systems and machine-readable media are also provided.

Abstract translation: 提供了用于生成和执行基于用户的常规查询的计算机实现的方法。 一方面，一种方法包括基于基于用户的查询和地理上下文来确定是否生成通知。 该方法还包括通过显式或推断的过滤条件过滤通知。 还提供系统和机器可读介质。

公开(公告)号：US20140282660A1

公开(公告)日：2014-09-18

申请号：US13827413

申请日：2013-03-14

Applicant: Ant Oztaskent ,  Yaroslav Volovich ,  David Singleton ,  Timbo Drayson

Inventor： Ant Oztaskent ,  Yaroslav Volovich ,  David Singleton ,  Timbo Drayson

IPC: H04N21/482

CPC classification number: H04N21/4828 ,  H04N21/41407 ,  H04N21/4394 ,  H04N21/44008 ,  H04N21/47217 ,  H04N21/4722 ,  H04N21/4725 ,  H04N21/6582 ,  H04N21/8133

Abstract: Methods, systems, and media for presenting mobile content corresponding to media content are provided. In some implementations, a method for providing information relating to media content is provided, the method comprising: determining a channel that is providing the television program; causing images relating to the television program to be presented, wherein the images are selected based on the channel and a time parameter; receiving a user selection of an image; identifying an entity within the selected image using one or more image recognition techniques; generating a search query based at least in part on the identified entity; obtaining search results responsive to the generated search query; and causing at least one of the search results to be presented to the mobile device in response to receiving the user selection of the image.

Abstract translation: 提供了用于呈现与媒体内容对应的移动内容的方法，系统和媒体。 在一些实现中，提供了一种用于提供与媒体内容相关的信息的方法，所述方法包括：确定正在提供所述电视节目的频道; 引起与电视节目有关的图像，其中基于频道和时间参数来选择图像; 接收用户对图像的选择; 使用一个或多个图像识别技术识别所选图像内的实体; 至少部分地基于所识别的实体生成搜索查询; 响应于所生成的搜索查询获得搜索结果; 以及响应于接收到所述图像的用户选择，使所述搜索结果中的至少一个呈现给所述移动设备。