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    Protein O-sulfonation
    3.
    发明申请
    Protein O-sulfonation 失效
    蛋白O-磺化

    公开(公告)号：US20070059771A1

    公开(公告)日：2007-03-15

    申请号：US11595319

    申请日：2006-11-09

    申请人： Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

    发明人： Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

    IPC分类号： G01N33/53 ,  C07K16/18

    CPC分类号： G01N33/6842 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/6803

    摘要： Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

    摘要翻译： 检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较， 并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。 使用生理条件的预定变化来推测O-磺化的具体变化。 通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。 这些方法包括引入或增加O-磺化，消除或减少O-磺化; 并衍生化或取代O-磺化。

    Protein O-sulfonation
    4.
    发明申请
    Protein O-sulfonation 有权
    蛋白O-磺化

    公开(公告)号：US20050054020A1

    公开(公告)日：2005-03-10

    申请号：US10657027

    申请日：2003-09-05

    申请人： Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

    发明人： Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

    IPC分类号： C07K16/44 ,  C12N20060101 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  G01N33/68

    CPC分类号： G01N33/6842 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/6803

    摘要： Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

    摘要翻译： 检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较， 并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。 使用生理条件的预定变化来推测O-磺化的具体变化。 通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。 这些方法包括引入或增加O-磺化，消除或减少O-磺化; 并衍生化或取代O-磺化。