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公开(公告)号：US08409574B2
公开(公告)日：2013-04-02
申请号：US12859990
申请日：2010-08-20
申请人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K39/00 , A61K31/415 , A61K31/335 , A01N43/52 , A01N43/32 , C07D309/00
CPC分类号： A61K31/357 , A61K31/337 , A61K31/4188 , A61K31/495 , A61K39/3955 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.
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2.发明授权Biologically active taxane analogs and methods of treatment by oral administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US08552056B2
公开(公告)日：2013-10-08
申请号：US13620852
申请日：2012-09-15
申请人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K31/335 , A61K31/44 , C07D407/00 , C07D309/00
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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3.发明申请Biologically Active Taxane Analogs And Methods Of Treatment By Oral Administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US20110135712A1
公开(公告)日：2011-06-09
申请号：US12873477
申请日：2010-09-01
申请人： James D. McChesney , Gilles TAPOLSKY , David E. EMERSON , John MARSHALL , Tauseef AHMED , Allen COHN , Michael KURMAN , Manuel MODIANO
发明人： James D. McChesney , Gilles TAPOLSKY , David E. EMERSON , John MARSHALL , Tauseef AHMED , Allen COHN , Michael KURMAN , Manuel MODIANO
IPC分类号： A61K39/395 , C07D493/04 , A61K31/357 , A61K9/127 , A61K31/573 , A61K38/22 , A61K38/44 , A61K31/395 , A61K33/24 , A61K31/7064 , A61P35/00
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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4.发明申请Biologically Active Taxane Analogs And Methods Of Treatment By Oral Administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US20130022668A1
公开(公告)日：2013-01-24
申请号：US13620852
申请日：2012-09-15
申请人： James D. McChesney , Gilles TAPOLSKY , David L. EMERSON , John MARSHALL , Tauseef AHMED , Allen COHN , Michael KURMAN , Manuel MODIANO
发明人： James D. McChesney , Gilles TAPOLSKY , David L. EMERSON , John MARSHALL , Tauseef AHMED , Allen COHN , Michael KURMAN , Manuel MODIANO
IPC分类号： A61K31/357 , A61P31/10 , A61K9/48 , A61K9/00 , A61K9/127
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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5.发明授权Biologically active taxane analogs and methods of treatment by oral administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US08273789B2
公开(公告)日：2012-09-25
申请号：US12873477
申请日：2010-09-01
申请人： James D. McChesney , Gilles Tapolsky , David L. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David L. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K31/35 , A61K31/335 , C07D309/00 , C07D407/00
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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公开(公告)号：US20110318334A1
公开(公告)日：2011-12-29
申请号：US12859990
申请日：2010-08-20
申请人： James D. McChesney , Gilles TAPOLSKY , David L. EMERSON , John MARSHALL , Tauseef AHMED , Allen COHN , Michael KURMAN , Manuel MODIANO
发明人： James D. McChesney , Gilles TAPOLSKY , David L. EMERSON , John MARSHALL , Tauseef AHMED , Allen COHN , Michael KURMAN , Manuel MODIANO
IPC分类号： A61K31/357 , A61P35/00 , A61K39/395 , C07D493/04 , A61K31/4188
CPC分类号： A61K31/357 , A61K31/337 , A61K31/4188 , A61K31/495 , A61K39/3955 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.
摘要翻译： 本文提供了用于治疗哺乳动物中脑癌的化合物和方法，其中所述方法包括在有丝分裂期间向哺乳动物给予在G2-M界面稳定微管蛋白二聚体或微便利的化合物，但不是MDR蛋白的底物。 特别地，本申请涉及口服有效的紫杉烷单独或与替莫唑胺或贝伐珠单抗联合用于治疗脑癌的用途。
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7.发明申请Biologically Active Taxane Analogs and Methods of Treatment by Oral Administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US20140023699A1
公开(公告)日：2014-01-23
申请号：US13950316
申请日：2013-07-25
申请人： James D. McChesney , Gilles H. Tapolsky , David Lloyd Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel R. Modiano
发明人： James D. McChesney , Gilles H. Tapolsky , David Lloyd Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel R. Modiano
IPC分类号： C07D493/06 , A61K39/395 , A61K31/495 , A61K31/357 , A61K45/06
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及用于治疗癌症的新型化合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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公开(公告)号：US20160176894A1
公开(公告)日：2016-06-23
申请号：US14950605
申请日：2015-11-24
IPC分类号： C07D493/06 , A61N5/10 , A61K39/395 , A61K45/06 , A61K31/357 , A61K31/53
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K31/53 , A61K39/395 , A61K39/3955 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
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公开(公告)号：US09227983B2
公开(公告)日：2016-01-05
申请号：US14539706
申请日：2014-11-12
IPC分类号： C07D493/06 , A61K31/357 , A61K45/06 , A61K39/395 , A61K31/495
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K31/53 , A61K39/395 , A61K39/3955 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
摘要翻译： 本申请公开了新的紫杉烷类似物，中间体及其生产方法。 本申请还涉及包含抗紫杉烷类的药物制剂和用抗紫杉烷类药物治疗癌症的方法。
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公开(公告)号：US20140093503A1
公开(公告)日：2014-04-03
申请号：US14110423
申请日：2012-04-06
IPC分类号： C07D493/06 , A61K45/06 , A61K31/357
CPC分类号： C07D493/06 , A61K31/357 , A61K45/06 , C07D493/04
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
摘要翻译： 本申请公开了新的紫杉烷类似物，中间体及其生产方法。 本申请还涉及包含抗紫杉烷类的药物制剂和用抗紫杉烷类药物治疗癌症的方法。
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