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1.发明授权Biological reagents and methods for determining the mechanism in the generation of &bgr;-amyloid peptide 失效用于确定β-淀粉样蛋白肽生成机制的生物试剂和方法公开(公告)号：US06486350B1
公开(公告)日：2002-11-26
申请号：US09408283
申请日：1999-09-29
申请人： James E. Audia , Paul A. Hyslop , Jeffrey S. Nissen , Richard C. Thompson , Jay S. Tung , Laura I. Tanner
发明人： James E. Audia , Paul A. Hyslop , Jeffrey S. Nissen , Richard C. Thompson , Jay S. Tung , Laura I. Tanner
IPC分类号： C07C23305
CPC分类号： C07C235/34 , C07C271/16 , C07C271/20 , C07K5/06191 , G01N33/6896
摘要： Disclosed are biological reagents which comprise compounds that inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of &bgr;-amyloid peptide.
摘要翻译： 公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的生物试剂，因此具有用于确定参与β-淀粉样蛋白肽生成的细胞机制。
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2.发明授权Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis 失效用于抑制β-淀粉样蛋白肽释放和/或其合成的方法和化合物公开(公告)号：US06888022B2
公开(公告)日：2005-05-03
申请号：US09789487
申请日：2001-02-20
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
CPC分类号： C07K5/06191 , A61K31/00 , A61K31/4015 , A61K31/405 , A61K31/445 , A61K31/47 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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3.发明授权N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds 失效N-（芳基/杂芳基/烷基乙酰基）氨基酸酰胺，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US06262302B1
公开(公告)日：2001-07-17
申请号：US09398211
申请日：1999-09-17
申请人： Jing Wu , Jay S. Tung , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Clark N. Eid , James E. Audia
发明人： Jing Wu , Jay S. Tung , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Clark N. Eid , James E. Audia
IPC分类号： C07C22938
CPC分类号： A61K31/277 , A61K31/198 , A61K31/223 , A61K31/44
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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公开(公告)号：US06211235B1
公开(公告)日：2001-04-03
申请号：US09164448
申请日：1998-09-30
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Jon K. Reel , Warren J. Porter , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Beverly K. Folmer , James J. Droste , Thomas C. Britton , James E. Audia
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Jon K. Reel , Warren J. Porter , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Beverly K. Folmer , James J. Droste , Thomas C. Britton , James E. Audia
IPC分类号： A01N3712
CPC分类号： C07K5/06191 , A61K31/00 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.
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5.发明授权Compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis 有权用于抑制β-淀粉样蛋白肽释放和/或其合成的化合物公开(公告)号：US06207710B1
公开(公告)日：2001-03-27
申请号：US09164385
申请日：1998-09-30
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu
IPC分类号： A01N3712
CPC分类号： A61K31/00 , A61K38/05 , A61K38/06 , C07K5/06078 , C07K5/06191
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物。
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6.发明授权Methods and compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis 失效用于抑制β-淀粉样蛋白肽释放和/或其合成的方法和化合物公开(公告)号：US06191166B1
公开(公告)日：2001-02-20
申请号：US08976289
申请日：1997-11-21
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , John Varghese , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , John Varghese , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
IPC分类号： A01N3712
CPC分类号： C07K5/06191 , A61K31/00 , A61K31/4015 , A61K31/405 , A61K31/445 , A61K31/47 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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7.发明授权N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds 失效N-（芳基/杂芳基/烷基乙酰基）氨基酸酰胺，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法
公开(公告)号：US6153652A
公开(公告)日：2000-11-28
申请号：US976295
申请日：1997-11-21
申请人： Jing Wu , Jay S. Tung , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Clark N. Eid , James E. Audia
发明人： Jing Wu , Jay S. Tung , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Clark N. Eid , James E. Audia
IPC分类号： A61K31/198 , A61K31/223 , A61K31/277 , A61K31/44 , A01N37/18 , A01N37/12 , A01N37/44 , A61K31/165
CPC分类号： A61K31/277 , A61K31/198 , A61K31/223 , A61K31/44
摘要： Disclosed are compounds which inhibit .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits .beta.-amyloid peptide release and/or its synthesis as well as methods for treating Alheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默氏病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性治疗阿尔海默氏病的方法。
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公开(公告)号：US06861558B2
公开(公告)日：2005-03-01
申请号：US10309569
申请日：2002-12-03
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
CPC分类号： C07K5/06191 , A61K31/00 , A61K31/4015 , A61K31/405 , A61K31/445 , A61K31/47 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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9.发明授权Compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis 失效用于抑制β-淀粉样蛋白肽释放和/或其合成的化合物公开(公告)号：US06476263B1
公开(公告)日：2002-11-05
申请号：US09826412
申请日：2001-04-03
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Jon K. Reel , Warren J. Porter , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Beverly K. Folmer , James J. Droste , Thomas C. Britton , James E. Audia
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Jon K. Reel , Warren J. Porter , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Beverly K. Folmer , James J. Droste , Thomas C. Britton , James E. Audia
IPC分类号： C07C23300
CPC分类号： C07K5/06191 , A61K31/00 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物。
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公开(公告)号：US6046215A
公开(公告)日：2000-04-04
申请号：US126572
申请日：1998-07-30
申请人： James E. Audia , Daniel J. Koch , Thomas E. Mabry , Jeffrey S. Nissen , Vincent P. Rocco , Yao-Chang Xu
发明人： James E. Audia , Daniel J. Koch , Thomas E. Mabry , Jeffrey S. Nissen , Vincent P. Rocco , Yao-Chang Xu
IPC分类号： A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61P25/04 , A61P43/00 , C07D211/68 , C07D333/58 , C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
摘要翻译： 本发明提供化合物和抑制哺乳动物中5-羟色胺再摄取的方法。
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