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公开(公告)号：US6150375A
公开(公告)日：2000-11-21
申请号：US210106
申请日：1998-12-11
申请人： James E. Audia , Loretta A. McQuaid , Blake L. Neubauer , Vincent P. Rocco , Kevin L. Haehl , Thomas J. Kress , James P. Wepsiec
发明人： James E. Audia , Loretta A. McQuaid , Blake L. Neubauer , Vincent P. Rocco , Kevin L. Haehl , Thomas J. Kress , James P. Wepsiec
IPC分类号： C12N9/99 , A61K31/435 , A61K31/47 , A61K31/473 , A61K31/495 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P5/28 , A61P13/02 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/08 , A61P17/14 , A61P35/00 , A61P43/00 , C07D221/10 , C07D221/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , C07F5/02 , C07D221/06 , C07D471/00
CPC分类号： C07D221/14 , C07D221/10 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , C07F5/025
摘要： A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5.alpha.-reductase.
摘要翻译： 一系列苯并喹啉-3-酮是有效治疗I型和II型5α-还原酶的病症的药物。
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公开(公告)号：US5846982A
公开(公告)日：1998-12-08
申请号：US862208
申请日：1997-05-22
申请人： James E. Audia , Daniel J. Koch , Thomas E. Mabry , Jeffrey S. Nissen , Vincent P. Rocco , Yao-Chang Xu
发明人： James E. Audia , Daniel J. Koch , Thomas E. Mabry , Jeffrey S. Nissen , Vincent P. Rocco , Yao-Chang Xu
IPC分类号： A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61P25/04 , A61P43/00 , C07D211/68 , C07D333/58 , C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14 , A61K31/43
CPC分类号： C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
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公开(公告)号：US5622962A
公开(公告)日：1997-04-22
申请号：US439405
申请日：1995-05-11
IPC分类号： C12N9/99 , A61K31/435 , A61K31/47 , A61K31/473 , A61K31/495 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P5/28 , A61P13/02 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/08 , A61P17/14 , A61P35/00 , A61P43/00 , C07D221/10 , C07D221/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , C07F5/02 , C07D221/06 , C07D237/00
CPC分类号： C07D221/14 , C07D221/10 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , C07F5/025
摘要： A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5.alpha.-reductase.
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公开(公告)号：US5576321A
公开(公告)日：1996-11-19
申请号：US468900
申请日：1995-06-06
申请人： Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
发明人： Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
IPC分类号： C07D237/28 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61K31/55 , A61P3/04 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D209/08 , C07D209/32 , C07D237/30 , C07D239/72 , C07D241/40 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D451/14 , C07D471/02 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D495/10 , C07D498/04 , C07D513/04 , A61K31/40 , C07D209/10 , C07D209/12 , C07D209/14
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US06172073B2
公开(公告)日：2001-01-09
申请号：US09049837
申请日：1998-03-27
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： A61K31445
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US5622961A
公开(公告)日：1997-04-22
申请号：US439396
申请日：1995-05-11
IPC分类号： C12N9/99 , A61K31/435 , A61K31/47 , A61K31/473 , A61K31/495 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P5/28 , A61P13/02 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/08 , A61P17/14 , A61P35/00 , A61P43/00 , C07D221/10 , C07D221/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , C07F5/02 , C07D221/06 , C07D237/00
CPC分类号： C07D221/14 , C07D221/10 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , C07F5/025
摘要： A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5.alpha.-reductase.
摘要翻译： 一系列苯并喹啉-3-酮是有效治疗I型和II型5α-还原酶的病症的药物。
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公开(公告)号：US5614523A
公开(公告)日：1997-03-25
申请号：US470512
申请日：1995-06-06
申请人： James E. Audia , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/50 , C07D241/04
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US6046215A
公开(公告)日：2000-04-04
申请号：US126572
申请日：1998-07-30
申请人： James E. Audia , Daniel J. Koch , Thomas E. Mabry , Jeffrey S. Nissen , Vincent P. Rocco , Yao-Chang Xu
发明人： James E. Audia , Daniel J. Koch , Thomas E. Mabry , Jeffrey S. Nissen , Vincent P. Rocco , Yao-Chang Xu
IPC分类号： A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61P25/04 , A61P43/00 , C07D211/68 , C07D333/58 , C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
摘要翻译： 本发明提供化合物和抑制哺乳动物中5-羟色胺再摄取的方法。
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公开(公告)号：US5741789A
公开(公告)日：1998-04-21
申请号：US467434
申请日：1995-06-06
申请人： David J. Hibschman , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
发明人： David J. Hibschman , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , C07D227/00 , A61K31/395 , A61K31/445
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US5627196A
公开(公告)日：1997-05-06
申请号：US468948
申请日：1995-06-06
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/445 , C07D409/00
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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