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1.发明授权
公开(公告)号：US5344449A
公开(公告)日：1994-09-06
申请号：US88066
申请日：1993-07-06
CPC分类号： B29D11/023 , A61L27/14 , A61F2002/1686 , B29C59/14
摘要： New intraocular lenses, fixation member assemblies for use in such lenses and methods for making the same are disclosed. In one embodiment, the present invention involves a method for producing a fixation member assembly which comprises exposing a fixation member component to a first plasma at conditions effective to enhance, relative to a substantially identical fixation member component which is not subjected to the exposing step, the bondability between the fixation member component and a polymeric coating to be located on the fixation member component; and exposing the fixation member to a second plasma in the presence of at least one material selected from polymeric components, polymerizable components and mixtures thereof at conditions effective to form the polymeric coating located on the fixation member component. Enhanced bondability between the polymeric coating-containing fixation member component and the optic of the intraocular lens and/or enhanced biocompatibility are preferably provided.
摘要翻译： 公开了新的眼内透镜，用于这种透镜的固定构件组件及其制造方法。 在一个实施例中，本发明涉及一种用于制造固定构件组件的方法，该方法包括：将固定构件组件暴露于第一等离子体，其条件是有效地相对于基本上相同的不经过曝光步骤的固定构件部件， 固定构件部件和位于固定构件部件上的聚合物涂层之间的粘合性; 以及在有效地形成位于固定构件部件上的聚合物涂层的条件下，在选自聚合物组分，可聚合组分及其混合物中的至少一种材料的存在下将固定构件暴露于第二等离子体。 优选提供增强的含聚合物涂层的固定构件组件和眼内透镜的光学元件之间的粘合性和/或增强的生物相容性。
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2.发明授权
公开(公告)号：US5262097A
公开(公告)日：1993-11-16
申请号：US824556
申请日：1992-01-23
CPC分类号： B29D11/023 , A61L27/14 , A61L27/34 , A61F2002/1686 , A61L2400/18 , B29C59/14
摘要： New intraocular lenses, fixation member assemblies for use in such lenses and methods for making the same. In one embodiment, the present invention involves a method for producing a fixation member assembly which includes exposing a fixation member component to a first plasma at conditions effective to enhance, relative to a substantially identical fixation member component which is not subjected to the exposing step, the bondability between the fixation member component and a polymeric coating to be located on the fixation member component; and exposing the fixation member to a second plasma in the presence of at least one material selected from polymeric components, polymerizable components and mixtures thereof at conditions effective to form the polymeric coating located on the fixation member component. Enhanced bondability between the polymeric coating-containing fixation member component and the optic of the intraocular lens and/or enhanced biocompatibility are preferably provided.
摘要翻译： 新的眼内透镜，用于这种透镜的固定构件组件及其制造方法。 在一个实施例中，本发明涉及一种用于生产固定构件组件的方法，该方法包括：将固定构件部件暴露于第一等离子体，其条件是有效地相对于不经受曝光步骤的基本上相同的固定构件部件， 固定构件部件和位于固定构件部件上的聚合物涂层之间的粘合性; 以及在有效地形成位于固定构件部件上的聚合物涂层的条件下，在选自聚合物组分，可聚合组分及其混合物中的至少一种材料的存在下将固定构件暴露于第二等离子体。 优选提供增强的含聚合物涂层的固定构件组件和眼内透镜的光学元件之间的粘合性和/或增强的生物相容性。
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3.发明授权
公开(公告)号：US6107347A
公开(公告)日：2000-08-22
申请号：US536408
申请日：1995-09-29
IPC分类号： A61K9/00 , A61K31/715 , A61K31/728 , A61K47/00
CPC分类号： A61K9/0048 , A61K31/715 , A61K31/728 , Y10S514/912
摘要： Compositions and methods useful for protecting human or animal eye cell layers and tissues exposed to trauma, e.g., during surgery, are disclosed. In one embodiment, the method comprises administering a protective amount of an ophthalmically acceptable aqueous composition containing a first alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of at least about 2 million, for example, in the range of about 2 million to about 4 million, and a second alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of about 200,000 to about 800,000, for example, in the range of about 300,000 to 700,000, to eye cell layers and tissues prior to the exposure to the trauma.
摘要翻译： 公开了用于保护人或动物眼细胞层和暴露于外伤的组织的组合物和方法，例如在手术期间。 在一个实施方案中，所述方法包括施用保护量的眼科可接受的水性组合物，其含有分子量至少约2百万的第一碱金属和/或碱土金属透明质酸酯部分，例如约2 百万至约四百万，以及第二碱金属和/或碱土金属透明质酸酯部分，其分子量为约200,000至约800,000，例如约300,000至700,000，在眼细胞层和组织之前， 暴露于创伤。
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公开(公告)号：US5492936A
公开(公告)日：1996-02-20
申请号：US965581
申请日：1992-10-23
IPC分类号： A61K9/00 , A61K31/715 , A61K31/728 , A61K47/00
CPC分类号： A61K9/0048 , A61K31/715 , A61K31/728 , Y10S514/912
摘要： Compositions and methods useful for protecting human or animal eye cell layers and tissues exposed to trauma, e.g., during surgery, are disclosed. In one embodiment, the method comprises administering a protective amount of an ophthalmically acceptable aqueous composition containing a first alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of at least about 2 million, for example, in the range of about 2 million to about 4 million, and a second alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of about 200,000 to about 800,000, for example, in the range of about 300,000 to 700,000, to eye cell layers and tissues prior to the exposure to the trauma.
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公开(公告)号：US5433745A
公开(公告)日：1995-07-18
申请号：US135875
申请日：1993-10-13
摘要： New corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating comprising a synthetic polymeric component located on the outer surface, covalently bonded to the hydrogel composition and having enhanced ability to support epithelial cell growth and/or adhesion relative to the hydrogel composition.
摘要翻译： 公开了新的角膜植入物和用于生产这种植入物的方法。 本发明的角膜植入物包括光学透明的透镜体，其被构造成手术附着在哺乳动物眼睛的角膜中或上面，所述透镜体包括具有外表面并且由含有水和亲水性的水凝胶组合物制成的芯 聚合物材料和包含位于外表面上的合成聚合物组分的涂层，共价键合到水凝胶组合物上，并具有增强的相对于水凝胶组合物支持上皮细胞生长和/或粘附的能力。
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公开(公告)号：US5976466A
公开(公告)日：1999-11-02
申请号：US869899
申请日：1992-04-15
申请人： Buddy D. Ratner , James E. Francese
发明人： Buddy D. Ratner , James E. Francese
IPC分类号： G01N29/02 , G01N29/44 , G01N33/543 , G01N33/545 , G01N33/48
CPC分类号： G01N29/449 , G01N29/022 , G01N33/54373 , G01N33/545 , G01N2291/014 , G01N2291/02466 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2291/106
摘要： There is disclosed a diagnostic sensor device comprising a plurality of sensor probes, a detection device, and a computer for analyzing the signals generated from each sensor probe by multivariate statistical analysis. The plurality of sensor probes comprise a substrate that allows transmission of a signal and a partially selective surface coating the substrate wherein the partially selective surface binds proteins from a biological fluid by multiple, noncovalent interactions, and with the proviso that the partially selective surfaces of each sensor probe in the diagnostic sensor device be different. The diagnostic sensor device can be used as a method for diagnosing disease states in humans and animals, wherein the disease states are characterized by altered protein character and behavior of a biological fluid.
摘要翻译： 公开了一种诊断传感器装置，其包括多个传感器探针，检测装置和计算机，用于通过多变量统计分析来分析从每个传感器探针产生的信号。 多个传感器探针包括允许透射信号和部分选择性表面包被基质的基底，其中部分选择性表面通过多种非共价相互作用结合来自生物流体的蛋白，并且条件是每个 诊断传感器设备中的传感器探头不同。 诊断传感器装置可用作诊断人和动物疾病状态的方法，其中疾病状态的特征在于改变的生物流体的蛋白质特性和行为。
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