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    Corneal implants and methods for producing same
    1.
    发明授权
    Corneal implants and methods for producing same 失效
    角膜植入物及其生产方法

    公开(公告)号：US5433745A

    公开(公告)日：1995-07-18

    申请号：US135875

    申请日：1993-10-13

    申请人： Richard S. Graham ,  Crystal M. Cunanan ,  James E. Francese

    发明人： Richard S. Graham ,  Crystal M. Cunanan ,  James E. Francese

    IPC分类号： A61F2/14 ,  A61F2/16

    CPC分类号： A61F2/142 ,  A61F2/14

    摘要： New corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating comprising a synthetic polymeric component located on the outer surface, covalently bonded to the hydrogel composition and having enhanced ability to support epithelial cell growth and/or adhesion relative to the hydrogel composition.

    摘要翻译： 公开了新的角膜植入物和用于生产这种植入物的方法。 本发明的角膜植入物包括光学透明的透镜体，其被构造成手术附着在哺乳动物眼睛的角膜中或上面，所述透镜体包括具有外表面并且由含有水和亲水性的水凝胶组合物制成的芯 聚合物材料和包含位于外表面上的合成聚合物组分的涂层，共价键合到水凝胶组合物上，并具有增强的相对于水凝胶组合物支持上皮细胞生长和/或粘附的能力。

    Biostable corneal implants
    2.
    发明授权
    Biostable corneal implants 失效
    生物稳定性角膜植入物

    公开(公告)号：US5632773A

    公开(公告)日：1997-05-27

    申请号：US616786

    申请日：1996-03-15

    申请人： Richard S. Graham ,  Crystal M. Cunanan

    发明人： Richard S. Graham ,  Crystal M. Cunanan

    IPC分类号： A61F2/00 ,  A61F2/14 ,  A61L27/24

    CPC分类号： A61F2/14 ,  A61L27/24 ,  A61F2310/00365

    摘要： Corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a hydrogel composition containing water, a collagen component and a polymeric material covalently bonded to the collagen component. The hydrogel composition has enhanced biostability relative to an identical hydrogel composition without the polymeric material.

    摘要翻译： 公开了角膜植入物和用于生产这种植入物的方法。 本发明的角膜植入物包括光学透明的透镜体，其被构造成手术附着在哺乳动物眼睛的角膜中或上面，所述透镜体包括水凝胶组合物，所述水凝胶组合物含有水，胶原组分和共价键合到 胶原成分。 相对于没有聚合物材料的相同的水凝胶组合物，水凝胶组合物具有增强的生物稳定性。

    Intraocular lenses and methods for producing same
    7.
    发明授权
    Intraocular lenses and methods for producing same 失效
    人工晶状体及其制造方法

    公开(公告)号：US5423929A

    公开(公告)日：1995-06-13

    申请号：US143798

    申请日：1993-10-27

    申请人： Christopher E. Doyle ,  Bernard F. Grisoni ,  Richard S. Graham

    发明人： Christopher E. Doyle ,  Bernard F. Grisoni ,  Richard S. Graham

    IPC分类号： A61L27/00 ,  A61F2/16 ,  A61L27/18 ,  A61L27/34 ,  B29D11/02 ,  B32B31/00

    CPC分类号： B29D11/023 ,  A61L27/18 ,  A61L27/34 ,  A61F2002/1686 ,  A61L2430/16 ,  Y10T156/1052

    摘要： New intraocular lenses (IOLs) and methods for producing IOLs are disclosed. The present methods include a combination of steps which increase the pull strength between the fixation member of the IOL and the optic of the IOL without requiring sophisticated high frequency corona discharge activation or plasma activation of the fixation member. The fixation members are doubly coated with primer components and silicone polymeric material precursor compositions before being secured to the optics. In addition, the optic members employed in the present invention can be formed, for example, molded, without recesses to accommodate the fixation members. Thus, such recesses can be formed and provided with a quantity of the above-noted precursor composition after the optic members are produced. The doubly coated fixation members are then placed in the recesses and secured to the optic members. The present methods are straight forward, easy to practice and are cost effective in producing high quality IOLs.

    摘要翻译： 公开了新的眼内透镜（IOL）和用于制造IOL的方法。 本方法包括增加IOL的固定构件和IOL的光学元件之间的拉伸强度的步骤的组合，而不需要复杂的高频电晕放电激活或固定构件的等离子体激活。 固定构件在固定到光学器件之前用底漆组分和硅氧烷聚合物材料前体组合物双重涂覆。 此外，本发明中使用的光学构件可以形成为例如模制而不具有凹部以容纳固定构件。 因此，在制造光学构件之后，可以形成这样的凹部并提供一定量的上述前体组合物。 然后将双重涂覆的固定构件放置在凹部中并固定到光学构件。 目前的方法是直观的，易于实践的，并且在生产高质量的IOL中具有成本效益。

    Recombinant bateriophage for heterologous cloning of bacillus microorganisms and method for its production
    10.
    发明授权
    Recombinant bateriophage for heterologous cloning of bacillus microorganisms and method for its production 失效
    用于异源克隆芽孢杆菌微生物的重组噬菌体及其生产方法

    公开(公告)号：US4886754A

    公开(公告)日：1989-12-12

    申请号：US740312

    申请日：1985-06-03

    申请人： Richard S. Graham ,  Yuko Yoneda ,  Frank E. Young

    发明人： Richard S. Graham ,  Yuko Yoneda ,  Frank E. Young

    IPC分类号： C12N7/01 ,  C12N9/28 ,  C12N15/75

    CPC分类号： C12N9/2417 ,  C12N15/75 ,  Y10S435/832 ,  Y10S435/839

    摘要： A recombinant bacteriophage, a method for producing and selecting the recombinant bacteriophage and a method for heterologous cloning of DNA are disclosed. The recombinant bacteriophage is produced by ligating genetic fragments encoding a desired genetic trait with DNA from a bacteriophage, incubating with DNA from a second Bacillus microorganism prototrophic for a growth requirement, incubating with a host Bacillus auxotrophic for the growth requirement. Transformed host Bacillus are selected by growing the mixture on a growth medium which does not contain the growth requirement and determining the presence of the genetic trait. The recombinant bacteriophage containing the desired genetic trait is recovered from the host Bacillus by induction. Heterologous cloning can be accomplished by incubating a host Bacillus with the recombinant bacteriophage.

    摘要翻译： 公开了重组噬菌体，重组噬菌体的制备和选择方法以及异源克隆DNA的方法。 通过将编码期望的遗传性状的遗传片段与来自噬菌体的DNA连接起来，与来自第二种芽孢杆菌微生物原生质体的DNA一起孵育以用于生长需求，通过与宿主芽孢杆菌营养缺陷型孵育用于生长需要来产生重组噬菌体。 通过在不含生长需要并确定遗传性状的存在的生长培养基上生长混合物来选择转化的宿主芽孢杆菌。 通过诱导从宿主芽孢杆菌中回收含有所需遗传特征的重组噬菌体。 可以通过将宿主芽孢杆菌与重组噬菌体一起孵育来实现异源克隆。