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15 条记录 (耗时 0.064 秒)

    RNA Interference Mediated Inhibition of GRB2 Associated Binding Protein (GAB2) Gene Expression Using Short Interfering Nucleic Acid (siNA)
    5.
    发明申请
    RNA Interference Mediated Inhibition of GRB2 Associated Binding Protein (GAB2) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
    RNA干扰介导的使用短干扰核酸（siNA）的GRB2相关结合蛋白（GAB2）基因表达的抑制

    公开(公告)号：US20100130592A1

    公开(公告)日：2010-05-27

    申请号：US12640668

    申请日：2009-12-17

    申请人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    发明人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  A61P35/00 ,  A61P37/08

    CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

    摘要： This invention relates to compounds, compositions, and methods useful for modulating GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of GRB2 associated binding protein (GAB2) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GAB2 genes. The small nucleic acid molecules are useful in the treatment of cancer, malignant blood disease (leukemia), inflammatory diseases or conditions, allergic diseases or conditions, or proliferative diseases or conditions.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节GRB2相关结合蛋白（GAB2）基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节参与GRB2相关结合蛋白（GAB2）基因表达和/或通过RNA干扰（RNAi）的活性的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节GAB2基因表达的方法。 小核酸分子可用于治疗癌症，恶性血液病（白血病），炎性疾病或病症，过敏性疾病或病症，或增殖性疾病或病症。

    RNA INTERFERENCE MEDIATED INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
    6.
    发明申请
    RNA INTERFERENCE MEDIATED INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 有权
    RNA干扰介导的人类免疫缺陷病毒（HIV）基因表达的抑制使用短暂的干扰核酸（siNA）

    公开(公告)号：US20110015251A1

    公开(公告)日：2011-01-20

    申请号：US12777767

    申请日：2010-05-11

    申请人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    发明人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    IPC分类号： A61K31/713 ,  C07H21/00 ,  A61P31/18

    CPC分类号： C12N15/1132 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521 ,  C12N2310/3533

    摘要： This invention relates to compounds, compositions, and methods useful for modulating human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of human immunodeficiency virus (HIV) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of HIV genes. The small nucleic acid molecules are useful in the treatment of HIV infection, AIDS, and/or disease and conditions related to HIV infection and/or AIDS in a subject or organism.

    摘要翻译： 本发明涉及可用于使用短干扰核酸（siNA）分子调节人免疫缺陷病毒（HIV）基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节涉及人免疫缺陷病毒（HIV）基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节HIV基因表达的方法。 小核酸分子可用于治疗受试者或生物体中的HIV感染，AIDS和/或与HIV感染和/或AIDS相关的疾病和病症。

    RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
    7.
    发明申请
    RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA) 审中-公开
    RNA干扰介导的使用化学修饰的短干扰核酸（siNA）的基因表达的抑制

    公开(公告)号：US20100240730A1

    公开(公告)日：2010-09-23

    申请号：US12748075

    申请日：2010-03-26

    申请人： LEONID BEIGELMAN ,  JAMES MCSWIGGEN

    发明人： LEONID BEIGELMAN ,  JAMES MCSWIGGEN

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  A61P43/00

    CPC分类号： A61K31/7088 ,  A61K9/0019 ,  A61K9/0051 ,  A61K47/544 ,  A61K47/549 ,  A61K47/551 ,  A61K47/554 ,  A61K47/60 ,  A61K47/64 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2310/3521

    摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, cosmetic, cosmeceutical, prophylactic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of disease (e.g., cancer, proliferative, inflammatory, metabolic, autoimmune, neurologic, ocular diseases), condition, trait (e.g., hair growth and removal), genotype and phenotype that responds to modulation of gene expression or activity in a cell, tissue, or organism. Such small nucleic acid molecules can be administered systemically, locally, or topically.

    摘要翻译： 本发明涉及可用于调节多种应用中的基因表达的方法和试剂，包括用于治疗，化妆品，药​​妆，预防，诊断，靶标验证和基因组发现应用。 具体地，本发明涉及合成的化学修饰的小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA （shRNA）分子，其能够介导针对靶核酸序列的RNA干扰（RNAi）。 小核酸分子可用于治疗疾病（例如癌症，增殖性，炎性，代谢，自身免疫，神经系统，眼部疾病），病症，性状（例如毛发生长和移除），对调节作出响应的基因型和表型 在细胞，组织或生物体中的基因表达或活性。 这样的小核酸分子可以全身，局部或局部施用。

    RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
    8.
    发明申请
    RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
    RNA干扰介导的TNF和TNF受体基因表达的抑制使用短暂的核酸（siNA）

    公开(公告)号：US20120004403A1

    公开(公告)日：2012-01-05

    申请号：US13165635

    申请日：2011-06-21

    申请人： LEONID BEIGELMAN ,  JAMES MCSWIGGEN

    发明人： LEONID BEIGELMAN ,  JAMES MCSWIGGEN

    IPC分类号： C07H21/02

    CPC分类号： C07H21/02 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14

    摘要： This invention relates to compounds, compositions, and methods useful for modulating tumor necrosis factor and/or tumor necrosis factor receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of tumor necrosis factor and/or tumor necrosis factor receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of tumor necrosis factor and/or tumor necrosis factor receptor genes, (TNF and/or TNF receptor).

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节肿瘤坏死因子和/或肿瘤坏死因子受体基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸调节参与肿瘤坏死因子和/或肿瘤坏死因子受体基因表达和/或活性的其他基因的表达和活性的化合物，组合物和方法（RNAi） 酸分子。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节肿瘤坏死因子和/或肿瘤坏死因子受体基因（TNF和/或TNF受体）的表达的方法。

    RNA Interference Mediated Inhibition of Protein Tyrosine Phosphatase-1B (PTP-1B) Gene Expression Using Short Interfering Nucleic Acid (siNA)
    9.
    发明申请
    RNA Interference Mediated Inhibition of Protein Tyrosine Phosphatase-1B (PTP-1B) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
    RNA干扰介导的使用短干扰核酸（siNA）的蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的抑制作用

    公开(公告)号：US20100184825A1

    公开(公告)日：2010-07-22

    申请号：US12712985

    申请日：2010-02-25

    申请人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    发明人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    IPC分类号： A61K31/713 ,  C07H21/04 ,  A61P3/04 ,  A61P3/10

    CPC分类号： C12N15/8218 ,  A61K38/00 ,  A61K47/54 ,  A61K47/554 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/346 ,  C12N2320/51 ,  C12N2310/321 ,  C12N2310/3521 ,  C12N2310/322 ,  C12N2310/3533

    摘要： This invention relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PTP-1B gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of PTP-1B genes. Such small nucleic acid molecules are useful, for example, for treating, preventing, inhibiting, or reducing obesity, insulin resistance, diabetes (eg. type II and type I diabetes) in a subject or organism, and for any other disease, trait, or condition that is related to or will respond to the levels of PTP-1B in a cell or tissue, alone or in combination with other treatments or therapies.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节涉及PTP-1B基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节PTP-1B基因表达的方法。 这样的小核酸分子可用于例如治疗，预防，抑制或减少受试者或生物体内的肥胖，胰岛素抵抗，糖尿病（例如II型和I型糖尿病）和任何其它疾病，性状， 或与细胞或组织中PTP-1B水平相关或将会对其单独或与其它治疗或疗法组合相关的病症。

    RNA INTERFERENCE MEDIATED INHIBITION OF ANGIOPOIETIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
    10.
    发明申请
    RNA INTERFERENCE MEDIATED INHIBITION OF ANGIOPOIETIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
    RNA干扰介导的抗干扰素基因表达的抑制使用短暂的核酸（siNA）

    公开(公告)号：US20090137507A1

    公开(公告)日：2009-05-28

    申请号：US12166991

    申请日：2008-07-02

    申请人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    发明人： JAMES MCSWIGGEN ,  LEONID BEIGELMAN

    IPC分类号： A61K31/7105 ,  C07H21/02

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

    摘要： This invention relates to compounds, compositions, and methods useful for modulating Angiopoietin gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of Angiopoietin gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of Angiopoietin genes, such as Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Angiopoietin-3 (Ang-3), and Angiopoietin-4 (Ang-4).

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节血管生成素基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节参与血管生成素基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）（Ang-2），促血管生成素-2（Ang-2），促血管生成素-3（Ang-3）和促血管生成素-4（Ang-4）的分泌和调节促血管生成素基因表达的方法 ）。