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公开(公告)号：US20100024050A1
公开(公告)日：2010-01-28
申请号：US11777277
申请日：2007-07-12
IPC分类号： A01K67/027 , C12N15/11 , C12N15/00 , C12N1/21 , A01H5/00 , C12Q1/02 , C12P7/64 , C12N15/82 , C12N15/87
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译： 本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子 系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。
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公开(公告)号：US07259295B2
公开(公告)日：2007-08-21
申请号：US11087100
申请日：2005-03-21
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译： 本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子 系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。
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公开(公告)号：US20110250342A1
公开(公告)日：2011-10-13
申请号：US13008756
申请日：2011-01-18
IPC分类号： A23D9/00 , C12N15/63 , C12N1/00 , C12N5/10 , A23L1/36 , C12N1/19 , C12N1/21 , C12P1/00 , A01H5/10 , C07H21/04 , A01H5/00
CPC分类号： C12N15/8247 , C07K14/21 , C07K14/28 , C07K14/405 , C12N15/52 , C12P7/6427 , C12P7/6472
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译： 公开了来自裂殖壶菌的完全多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）系统及其生物活性片段及其同源物。 更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用 本文公开的PUFA PKS系统。 本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。
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公开(公告)号：US07608703B2
公开(公告)日：2009-10-27
申请号：US11689605
申请日：2007-03-22
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
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公开(公告)号：US07608702B2
公开(公告)日：2009-10-27
申请号：US11689587
申请日：2007-03-22
IPC分类号： C12N15/52 , C12N15/53 , C12N15/54 , C12N15/60 , C12N15/74 , C12N15/79 , C12N15/82 , C12P7/64
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
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公开(公告)号：US07271315B2
公开(公告)日：2007-09-18
申请号：US11452138
申请日：2006-06-12
CPC分类号： C12P7/6472 , C12N15/52 , C12P7/6427 , C12P7/6463
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译： 公开了来自裂殖壶菌的完全多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）系统及其生物活性片段及其同源物。 更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用 本文公开的PUFA PKS系统。 本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。
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公开(公告)号：US07256023B2
公开(公告)日：2007-08-14
申请号：US11087085
申请日：2005-03-21
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
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8.发明授权Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof 有权编码PUFA聚酮化合物系统的ORFA的核酸分子及其用途公开(公告)号：US07247461B2
公开(公告)日：2007-07-24
申请号：US10124800
申请日：2002-04-16
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from Schizochytrium sp., to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译： 本发明一般涉及从裂殖酵母属分离自或衍生自裂殖壶菌属的多不饱和脂肪酸（PUFA）聚酮化合物（PKS）系统及其同源物，与分离的核酸分子和编码这种PUFA PKS系统的生物活性结构域的重组核酸分子 涉及包含PUFA PKS系统的转基因生物，制备和使用这些系统用于生产感兴趣的生物活性分子的方法，以及用于鉴定具有这种PUFA PKS系统的新的细菌和非细菌微生物的新方法。
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公开(公告)号：US07960524B2
公开(公告)日：2011-06-14
申请号：US11689596
申请日：2007-03-22
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译： 本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子 系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。
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公开(公告)号：US07919320B2
公开(公告)日：2011-04-05
申请号：US11777277
申请日：2007-07-12
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
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