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公开(公告)号：US06887192B1
公开(公告)日：2005-05-03
申请号：US09706307
申请日：2000-11-03
CPC分类号： A61F2/2481 , A61B2017/00039 , A61B2017/00243 , A61B2017/00734 , A61B2017/00862 , A61M1/1008 , A61M1/1055 , A61M1/1056 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M2205/33 , A61M2205/3303 , A61N2/02
摘要： This is a support device that prevents, reduces, and delays remodeling of diseased cardiac tissue, and also decreases the impact of such remodeling on collateral tissue is disclosed. The invention further reinforces abnormal tissue regions to prevent over-expansion of the tissue due to increased afterload and excessive wall tension. As a result, the support device prevents phenomenon such as systolic stretch from occurring and propagating. The support structure maintains and restores diastolic compliance, wall motion, and ejection fraction to preserve heart functionality. As such, the support device prevents and treats cardiomyopathy and congestive heart failure.
摘要翻译： 这是一种支持装置，其防止，减少和延迟患病心脏组织的重塑，并且还减少了这种重塑对侧支组织的影响。 本发明进一步加强了异常组织区域，以防止由于增加的后负荷和过度的壁张力导致组织的过度膨胀。 结果，支撑装置防止诸如收缩期拉伸的现象发生和传播。 支撑结构保持和恢复舒张顺应性，壁运动和射血分数以保持心脏功能。 因此，支持装置防止和治疗心肌病和充血性心力衰竭。
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公开(公告)号：US06599302B2
公开(公告)日：2003-07-29
申请号：US09329658
申请日：1999-06-10
IPC分类号： A61B1704
CPC分类号： A61F2/064 , A61B17/11 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306 , A61F2/91
摘要： A system and components for treating aortic aneurysms includes a reinforcing graft and fittings for securing the graft to a host vessel and to branch vessels, for example the iliac and renal arteries. Combinations of fittings and rings or other compression mechanisms secure vessels or grafts frictionally, for end-end or end-side couplings. A variety of tools are disclosed for manipulating retaining rings, everting portions of grafts or vessels in the course of coupling them to fittings, and clamping fittings while positioning the retaining rings.
摘要翻译： 用于治疗主动脉瘤的系统和组件包括加强移植物和用于将移植物固定到宿主血管和分支血管（例如髂动脉和肾动脉）的配件。 配件和环的组合或其他压缩机构摩擦地固定血管或移植物，用于端端或端侧联接。 公开了各种用于操作保持环，在将它们连接到配件的过程中的移植物或容器的弯曲部分以及夹持配件同时定位保持环的工具。
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公开(公告)号：US07083631B2
公开(公告)日：2006-08-01
申请号：US10243260
申请日：2002-09-12
IPC分类号： A61B17/08
CPC分类号： A61B17/11 , A61B17/34 , A61B2017/00247 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61B2018/00392 , A61F2/0009 , A61F2/0022 , A61F2/064 , A61F2/2424 , A61F2/2475 , A61F2250/0067 , A61M29/02
摘要： A bypass graft incorporates fixation mechanisms at its opposite ends, for securing these ends to different locations along a blood vessel, or alternatively to different locations wherein one of the locations is a different vessel or an organ defining a cavity. Mechanical fixation features such as collets or grommets can be employed, enhanced by delivery of an electrical current sufficient to heat surrounding tissue to form a thermal bond. A graft deployment system includes a tissue dilator and a needle for perforating tissue, mounted coaxially within the dilator. Intralumenal systems further include a catheter for containing the dilator.
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公开(公告)号：US06648900B2
公开(公告)日：2003-11-18
申请号：US09997619
申请日：2001-11-28
申请人： Sidney D. Fleischman , Russell A. Houser , James G. Whayne , Thomas H. Campbell , Patrick M. Owens
发明人： Sidney D. Fleischman , Russell A. Houser , James G. Whayne , Thomas H. Campbell , Patrick M. Owens
IPC分类号： A61B1708
CPC分类号： A61F2/064 , A61B17/11 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306 , A61F2/91
摘要： An end-side anastomosis system including a fitting including a base for attachment to a graft, the base be configured to form a seal with an opening in a host vessel wall a leading petal having a cross-section with a radius of curvature approximating a radius of curvature of the host vessel, the leading petal being configured to dilate the host vessel wall opening while advancing the fitting through the opening and a rear petal, the rear petal being deflectable to be advanced through the host vessel opening.
摘要翻译： 一种端侧吻合系统，包括包括用于附接到移植物的基部的配件，所述基座被构造成与主容器壁中的开口形成具有近似半径的曲率半径的横截面的前导花瓣的密封件 所述前花瓣被构造成在通过所述开口推进所述配件和后花瓣时扩张所述主容器壁开口，所述后花瓣可偏转以前进通过所述主容器开口。
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公开(公告)号：US06361559B1
公开(公告)日：2002-03-26
申请号：US09329504
申请日：1999-06-10
IPC分类号： A61F200
CPC分类号： A61F2/064 , A61B17/11 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306 , A61F2/91
摘要： A sutureless anastomosis systems for securing a bypass graft to a host vessel or other tubular structure including a bypass graft and fitting. A compression mechanism may be used with the system for attachment of the bypass graft to the fitting. An electrode is connected to the fitting and an energy source. The energy source transmits energy to the electrode and causes the adjacent tissue to rise in temperature and bond to a vessel or fitting.
摘要翻译： 用于将旁路移植物固定到宿主容器或其他包括旁路移植物和配件的管状结构的无缝合吻合系统。 压缩机构可以与系统一起使用以将旁路移植物附接到配件。 电极连接到配件和能源。 能量源将能量传递到电极并使相邻组织温度升高并且结合到容器或配件。
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公开(公告)号：US06887249B1
公开(公告)日：2005-05-03
申请号：US09721158
申请日：2000-11-21
CPC分类号： A61F2/064 , A61B17/11 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306 , A61F2/91
摘要： Anastomosis systems include fittings and compression mechanisms for effecting end-end or end-side couplings of biological or synthetic bypass grafts to vessel locations. The fittings are tubular and surround end regions of the graft. In some applications an end region of the graft is everted and surrounds an exterior of the fitting, in which case the preferred compression mechanism is a retaining ring. A tool is used to evert the graft end region. In other applications, the fitting has an interior groove that receives an expandable retaining ring that urges the graft end region radially outwardly against the fitting. A graft deploying and securing system includes a needle for puncturing vessel tissue, a dilator, and a sheath adapted for containing a graft/fitting combination and guiding the combination into the vessel through an opening formed by the needle and dilator.
摘要翻译： 吻合系统包括用于实现生物或合成旁路移植物到血管位置的端端或端侧耦合的配件和压缩机构。 配件是移植物的管状和环绕端部区域。 在一些应用中，移植物的端部区域是绕过的并且围绕配件的外部，在这种情况下，优选的压缩机构是保持环。 一个工具用于翻转移植物端区域。 在其他应用中，配件具有内部凹槽，该内部凹槽容纳可扩张的保持环，其将接枝端部区域向外径向向外抵靠配件。 移植物展开和固定系统包括用于穿刺血管组织的针，扩张器和适合于容纳移植物/装配组合的护套，并通过由针和扩张器形成的开口将组合引导到血管中。
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公开(公告)号：US06843795B1
公开(公告)日：2005-01-18
申请号：US09721405
申请日：2000-11-21
CPC分类号： A61F2/064 , A61B17/11 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306 , A61F2/91
摘要： Anastomosis systems include fittings and compression mechanisms for effecting end—end or end-side couplings of biological or synthetic bypass grafts to vessel locations. The fittings are tubular and surround end regions of the graft. In some applications an end region of the graft is everted and surrounds an exterior of the fitting, in which case the preferred compression mechanism is a retaining ring. A tool is used to evert the graft end region. In other applications, the fitting has an interior groove that receives an expandable retaining ring that urges the graft end region radially outwardly against the fitting. A graft deploying and securing system includes a needle for puncturing vessel tissue, a dilator, and a sheath adapted for containing a graft/fitting combination and guiding the combination into the vessel through an opening formed by the needle and dilator.
摘要翻译： 吻合系统包括用于实现生物或合成旁路移植物到血管位置的端端或端侧耦合的配件和压缩机构。 配件是移植物的管状和环绕端部区域。 在一些应用中，移植物的端部区域是绕过的并且围绕配件的外部，在这种情况下，优选的压缩机构是保持环。 一个工具用于翻转移植物端区域。 在其他应用中，配件具有内部凹槽，该内部凹槽容纳可扩张的保持环，其将接枝端部区域向外径向向外抵靠配件。 移植物展开和固定系统包括用于穿刺血管组织的针，扩张器和适合于容纳移植物/装配组合的护套，并通过由针和扩张器形成的开口将组合引导到血管中。
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公开(公告)号：US06740101B2
公开(公告)日：2004-05-25
申请号：US09329503
申请日：1999-06-10
IPC分类号： A61B1708
CPC分类号： A61F2/064 , A61B17/11 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306 , A61F2/91
摘要： Anastomosis systems include fittings and compression mechanisms for effecting end-end or end-side couplings of biological or synthetic bypass grafts to vessel locations. The fittings are tubular and surround end regions of the graft. In some applications an end region of the graft is everted and surrounds an exterior of the fitting, in which case the preferred compression mechanism is a retaining ring. A tool is used to evert the graft end region. In other applications, the fitting has an interior groove that receives an expandable retaining ring that urges the graft end region radially outwardly against the fitting. A graft deploying and securing system includes a needle for puncturing vessel tissue, a dilator, and a sheath adapted for containing a graft/fitting combination and guiding the combination into the vessel through an opening formed by the needle and dilator.
摘要翻译： 吻合系统包括用于实现生物或合成旁路移植物到血管位置的端端或端侧耦合的配件和压缩机构。 配件是移植物的管状和环绕端部区域。 在一些应用中，移植物的端部区域是绕过的并且围绕配件的外部，在这种情况下，优选的压缩机构是保持环。 一个工具用于翻转移植物端区域。 在其他应用中，配件具有内部凹槽，该内部凹槽容纳可扩张的保持环，其将接枝端部区域向外径向向外抵靠配件。 移植物展开和固定系统包括用于穿刺血管组织的针，扩张器和适合于容纳移植物/装配组合的护套，并通过由针和扩张器形成的开口将组合引导到血管中。
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公开(公告)号：US06494889B1
公开(公告)日：2002-12-17
申请号：US09654216
申请日：2000-09-01
IPC分类号： A61B1708
CPC分类号： A61B17/11 , A61B17/064 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306
摘要： This invention is related to devices and systems for creating sutureless anastomoses. In particular, this invention is related to devices for deploying and securing the ends of bypass grafts designed to provide a fluid flow passage between at least two vessels or tubular structures. A variety of compressible, expandable fittings, loading and delivery sheaths, tools, and other devices for creating end-end and end-side anastomoses, as well as methods for their use, are disclosed. In addition, robotic, remotely operable systems and devices for creating sutureless anastomoses in minimally invasive applications are disclosed. The systems of this invention do not require stopping or re-routing blood flow to perform an anastomosis between a bypass graft and a host vessel. Accordingly, this invention describes sutureless anastomosis systems that do not require cardiopulmonary bypass support when treating coronary artery disease.
摘要翻译： 本发明涉及用于创建无缝合吻合的装置和系统。 特别地，本发明涉及用于部署和固定旁路移植物的末端的装置，其设计成在至少两个血管或管状结构之间提供流体流动通道。 公开了各种可压缩，可扩张的配件，装载和传送护套，工具和用于创建端端和端侧吻合的其它装置，以及用于其使用的方法。 此外，公开了用于在微创应用中创建无缝合吻合的机器人，可远程操作的系统和装置。 本发明的系统不需要停止或重新路由血流来执行旁路移植物和宿主血管之间的吻合。 因此，本发明描述了当治疗冠状动脉疾病时不需要体外循环支持的无缝合吻合系统。
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公开(公告)号：US06648901B2
公开(公告)日：2003-11-18
申请号：US09730366
申请日：2000-12-05
申请人： Sidney D. Fleischman , Russell A. Houser , James G. Whayne , Thomas H. Campbell , Patrick M. Owens
发明人： Sidney D. Fleischman , Russell A. Houser , James G. Whayne , Thomas H. Campbell , Patrick M. Owens
IPC分类号： A61F206
CPC分类号： A61F2/064 , A61B17/11 , A61B17/32053 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/306 , A61F2/91
摘要： An end-side anastomosis system including a fitting comprising: a base for attachment to a graft, said base be configured to form a seal with an opening in a host vessel wall; a leading petal having a cross-section with a radius of curvature approximating a radius of curvature of the host vessel, said leading petal being configured to dilate the host vessel wall opening while advancing said fitting through the opening; and a rear petal, said rear petal being deflectable to be advanced through the host vessel opening.
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