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    Photonic crystal waveguides and systems using such waveguides
    7.
    发明申请
    Photonic crystal waveguides and systems using such waveguides 有权
    光子晶体波导和使用这种波导的系统

    公开(公告)号：US20050271340A1

    公开(公告)日：2005-12-08

    申请号：US10978605

    申请日：2004-11-01

    申请人： Ori Weisberg ,  Steven Jacobs ,  Maksim Skorobogatiy ,  Steven Johnson ,  Uri Kolodny

    发明人： Ori Weisberg ,  Steven Jacobs ,  Maksim Skorobogatiy ,  Steven Johnson ,  Uri Kolodny

    IPC分类号： G02B6/02 ,  G02B6/036

    CPC分类号： G02B6/02304 ,  G02B6/02328 ,  G02B6/02361 ,  G02B6/03622 ,  G02B6/03688 ,  G02B6/03694

    摘要： In general, in one aspect, the invention features an apparatus that includes a photonic crystal fiber configured to guide a mode of electromagnetic radiation at a wavelength, λ, along a waveguide axis. The fiber includes a core extending along the waveguide axis, and a confinement region extending along the waveguide axis and surrounding the core. The confinement region includes alternating layers of a first and a second dielectric material having thicknesses d1 and d2 and different refractive indices n1 and n2, respectively. The thickness of at least one of the alternating layers of the first material_differs from thickness d1QW or at least one of the alternating layers of the second material_differs from thickness d2QW, where d1QW and d2QW correspond to a quarter-wave condition for the two dielectric materials given by d1QW=λ/(4{square root}{square root over (n12−1)}) and d2QW=λ/(4{square root}{square root over (n22−1)}), respectively. The photonic crystal fiber has an attenuation for the guided mode at the wavelength λ that is reduced by a factor of about two or more relative to an attenuation for a reference fiber that is identical to the photonic crystal fiber except that the reference fiber has alternating layer thicknesses corresponding to the quarter-wave condition.

    摘要翻译： 通常，在一个方面，本发明的特征在于一种装置，其包括光子晶体光纤，其被配置为沿波导轴引导波长λ的电磁辐射模式。 光纤包括沿波导轴延伸的芯，以及沿着波导轴线延伸并围绕芯的约束区域。 限制区域包括具有厚度d 1和2 2的不同折射率n 1和n 2的第一和第二电介质材料的交替层，n 2 。 第一材料的至少一个交替层的厚度来自厚度d <1> QW /或第二材料的至少一个交替层，厚度d ，其中d <1> QW 和D <2> QW >对应于由d 1 / Q Q（λ）=λ/（4 {平方根} {平方根（n> 1）给出的两个介电材料的四分之一波长条件， 1 2 -1）}）和d 2 QW =λ/（4 {平方根} {平方根超过（ 2 2 -1）}）。 光子晶体光纤对于在波长λ处的导模的衰减相对于与光子晶体光纤相同的参考光纤的衰减相比减小约两倍或更多的因子，除了参考光纤具有交替层 厚度对应于四分之一波长条件。

    Fibronectin type III domain based scaffold compositions, methods and uses
    10.
    发明授权
    Fibronectin type III domain based scaffold compositions, methods and uses 有权
    纤连蛋白III型结构域的支架组合物，方法和用途

    公开(公告)号：US08293482B2

    公开(公告)日：2012-10-23

    申请号：US12704824

    申请日：2010-02-12

    申请人： Steven Jacobs ,  Karyn O'Neil

    发明人： Steven Jacobs ,  Karyn O'Neil

    IPC分类号： C07K16/00 ,  G01N33/53

    CPC分类号： C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

    摘要： A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

    摘要翻译： 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。