公开(公告)号：US20050169326A1

公开(公告)日：2005-08-04

申请号：US11045737

申请日：2005-01-28

Applicant: James Jacob ,  Andrew Merriam

Inventor： James Jacob ,  Andrew Merriam

IPC: H01S3/00 ,  H01S3/067 ,  H01S3/0941 ,  H01S3/10 ,  H01S3/108 ,  H01S3/109 ,  H01S3/16 ,  H01S3/23

CPC classification number: H01S3/2391 ,  H01S3/0085 ,  H01S3/0092 ,  H01S3/067 ,  H01S3/06712 ,  H01S3/06754 ,  H01S3/0941 ,  H01S3/108 ,  H01S3/109 ,  H01S3/1611 ,  H01S3/1618

Abstract: Several methods are disclosed for the generation of coherent short-wavelength electromagnetic radiation through optical nonlinear frequency mixing means. The invention involves several stages of efficient nonlinear frequency conversion to shift the output of high-power infra-red fiber-lasers into the vacuum ultraviolet (VUV). The described laser source architecture is designed around non-critically phase-matched (NCPM) sum-frequency mixing (SFM) interactions in the nonlinear crystal CLBO. The NCPM interaction is an optimum condition for bulk frequency conversion of cw radiation because it allows tight focusing of the input laser radiation without Poynting vector walk-off, thereby increasing the non-linear drive significantly. The sub-200-nm output wave is generated from SFM of a long-wave IR laser field and a short-wave UV laser field. The long-wave laser beam may be derived directly from a rare-earth-doped fiber laser, whereas the short-wavelength UV beam is provided as the fourth frequency harmonic of a second rare-earth-doped fiber laser system.

Abstract translation: 公开了通过光学非线性频率混合装置产生相干短波长电磁辐射的几种方法。 本发明涉及高效非线性频率转换的几个阶段，以将大功率红外光纤激光器的输出转换成真空紫外线（VUV）。 所描述的激光源架构设计在非线性晶体CLBO中的非临界相位匹配（NCPM）和频混频（SFM）相互作用。 NCPM相互作用是cw辐射的体积频率转换的最佳条件，因为它允许输入激光辐射的紧密聚焦，而没有坡印廷矢量离散，从而显着增加非线性驱动。 亚200nm输出波由长波红外激光场和短波紫外激光场的SFM产生。 长波激光束可以直接从稀土掺杂的光纤激光器得到，而短波长的紫外光束则作为第二稀土掺杂光纤激光器系统的第四频率谐波。

公开(公告)号：US20060223785A1

公开(公告)日：2006-10-05

申请号：US11269942

申请日：2005-11-08

Applicant: Rui Liu ,  James Jacob ,  Bud Tennant

Inventor： Rui Liu ,  James Jacob ,  Bud Tennant

IPC: A61K31/365 ,  A61K31/665

CPC classification number: A61K31/665 ,  A61K31/365

Abstract: The present invention provides a methods and compositions for treating a host afflicted with a viral infection, particularly a Flaviviridae infection, including hepatitis C infection, comprising administering an effective antiviral amount of a derivative of andrographolide alone or in combination or alternation with another antiviral compound.

公开(公告)号：US08716366B2

公开(公告)日：2014-05-06

申请号：US13557258

申请日：2012-07-25

Applicant: Rosamma Alex ,  Kavumnadayil Krishnan Sasidharan ,  James Jacob

Inventor： Rosamma Alex ,  Kavumnadayil Krishnan Sasidharan ,  James Jacob

IPC: C08J3/215

CPC classification number: C08K13/02 ,  C08C1/15 ,  C08J3/2053 ,  C08J3/22 ,  C08J2307/02

Abstract: The present invention relates to a process for preparing tri-filler incorporated natural rubber master batch. The fillers used in the present invention are carbon black, silica and nano-clay (modified montmorillonite clay, Cloisite 93 A). The process of preparing fillers incorporated master batch involves preparation of the individual filler dispersions by mixing each filler with surfactants. Further fresh rubber latex is soap sensitized by mixing it with surfactant. The filler dispersions are added to the soap sensitized rubber latex slowly under stirring to form the master mix. Then the master mix is coagulated by the addition of acid to form coagulum. The coagulum is dewatered and dried to obtain filler incorporated natural rubber master batch.

Abstract translation: 本发明涉及一种制备掺入天然橡胶母料的三填料的方法。 本发明中使用的填料是炭黑，二氧化硅和纳米粘土（改性蒙脱石粘土，Cloisite 93A）。 制备填充母料的填料的方法包括通过将各填料与表面活性剂混合来制备单独的填料分散体。 进一步的新鲜橡胶胶乳通过与表面活性剂混合而使其致敏。 在搅拌下将填料分散体缓慢加入到皂增感橡胶胶乳中以形成主混合物。 然后通过添加酸将主混合物凝结以形成凝结物。 将凝结物脱水干燥，得到填料天然橡胶母料。

公开(公告)号：US20120215456A1

公开(公告)日：2012-08-23

申请号：US13032652

申请日：2011-02-23

Applicant: John Hoffnagle ,  James Jacob

Inventor： John Hoffnagle ,  James Jacob

IPC: G06F19/00

CPC classification number: G01N15/147 ,  G01N15/1475 ,  G01N2015/149

Abstract: An optical system for non-invasive cytometry of mammalian cells includes a light source, a cell positioner, an optical imager, an optical wavefront sensor and a computer. The light source produces an illuminating beam of spatially coherent radiation. The cell positioner sequentially moves a single cell from a population of multiple cells into a sub-aperture region of the illumination beam whose wavefront is perturbed in response to the physical structure of the single cell. An optical system relays a magnified image of the sub-aperture region containing the cell to an image plane. At the image plane a Shack-Hartmann wavefront sensor is positioned. Within the pupil of the wavefront sensor the local tilts of the wavefront in the sub-aperture region are measured and sent to a computer. Software calculates the Zernike coefficients corresponding to the aberration induced by the structure of each cell. Their Zernike signatures classify the cells into distinct types.

Abstract translation: 用于哺乳动物细胞非侵入性细胞计数的光学系统包括光源，细胞定位器，光学成像仪，光学波前传感器和计算机。 光源产生空间相干辐射的照明光束。 单元定位器顺序地将单个单元从多个单元的群体移动到响应于单个单元的物理结构扰动波阵面的照明波束的子孔径区域。 光学系统将包含单元的子孔径区域的放大图像中继到像平面。 在图像平面，Shack-Hartmann波前传感器被定位。 在波前传感器的瞳孔内，测量子孔径区域中的波前的局部倾斜并将其发送到计算机。 软件计算对应于由每个单元的结构引起的像差的Zernike系数。 他们的Zernike签名将细胞分类为不同的类型。