公开(公告)号：US20080114343A1

公开(公告)日：2008-05-15

申请号：US11598476

申请日：2006-11-13

申请人： James Lowe ,  Gary Allen ,  Elbert Tzeng ,  Richard Lanigan ,  John McIntyre

发明人： James Lowe ,  Gary Allen ,  Elbert Tzeng ,  Richard Lanigan ,  John McIntyre

IPC分类号： A61B18/18 ,  A61B17/34

CPC分类号： A61B18/22 ,  A61B17/22012 ,  A61B17/3476 ,  A61B2017/00247 ,  A61B2017/3445 ,  A61B2017/3447 ,  A61B2018/00392 ,  A61B2018/2005

摘要： Methods for the treatment of ischemic limbs. An energy source, which will typically be a laser energy source deployed through an optic fiber, is deployed subcutaneously to a site of ischemic skeletal muscle. At the site, a plurality of channels are preferably systematically formed with an appropriate amount of activated energy, which in turn can facilitate the restoration of blood flow through new blood vessel formation. Optionally, a needle or cannula can be deployed in conjunction with the energy source to help facilitate the formation of channel formation and/or deliver a therapeutic agent at the sight of channel formation. A sheath may also be utilized to house the optic fiber and deliver a therapeutic agent.

摘要翻译： 治疗缺血性肢体的方法。 通常将通过光纤部署的激光能量源的能源皮下部署到缺血性骨骼肌的部位。 在该部位，多个通道优选地系统地形成有适量的活化能，这反过来可以促进通过新的血管形成恢复血流。 任选地，针或套管可以与能量源一起部署，以帮助促进通道形成的形成和/或在通道形成的视线下递送治疗剂。 也可以使用护套来容纳光纤并递送治疗剂。

公开(公告)号：US08012096B2

公开(公告)日：2011-09-06

申请号：US11543505

申请日：2006-10-05

申请人： John McIntyre ,  Elbert Tzeng

发明人： John McIntyre ,  Elbert Tzeng

IPC分类号： A61B8/14

CPC分类号： A61B17/3478 ,  A61B18/1477 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2018/00166 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61B2018/2005

摘要： The present invention contemplates a surgical device for both ablating a channel in a patient's tissue and also delivering a therapeutic agent. The device includes an elongated multi-lumen tube, an elongated tissue ablating assembly, and a therapeutic agent delivery assembly. The therapeutic agent is capable of being delivered into the channel and/or to the surrounding tissue. The device may further include a second multi-lumen tube also capable of delivering therapeutic agents. Although suitable for many operations, the device is particularly well suited for transmyocardial revascularization operations. The present invention also contemplates a procedure for using such a surgical device to ablate a channel in a patient's tissue and also deliver a therapeutic agent.

摘要翻译： 本发明考虑了用于消融患者组织中的通道并且还递送治疗剂的手术装置。 该装置包括细长多腔管，细长组织消融组件和治疗剂递送组件。 治疗剂能够被输送到通道和/或周围组织中。 该装置还可以包括还能够递送治疗剂的第二多腔管。 尽管适用于许多操作，该装置特别适用于经心肌血运重建操作。 本发明还考虑了使用这种外科装置消融患者组织中的通道并递送治疗剂的程序。

公开(公告)号：US20070088218A1

公开(公告)日：2007-04-19

申请号：US11543505

申请日：2006-10-05

申请人： John McIntyre ,  Elbert Tzeng

发明人： John McIntyre ,  Elbert Tzeng

IPC分类号： A61B8/14

CPC分类号： A61B17/3478 ,  A61B18/1477 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2018/00166 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61B2018/2005

摘要： The present invention contemplates a surgical device for both ablating a channel in a patient's tissue and also delivering a therapeutic agent. The device includes an elongated multi-lumen tube, an elongated tissue ablating assembly, and a therapeutic agent delivery assembly. The therapeutic agent is capable of being delivered into the channel and/or to the surrounding tissue. The device may further include a second multi-lumen tube also capable of delivering therapeutic agents. Although suitable for many operations, the device is particularly well suited for transmyocardial revascularization operations. The present invention also contemplates a procedure for using such a surgical device to ablate a channel in a patient's tissue and also deliver a therapeutic agent.

摘要翻译： 本发明考虑了用于消融患者组织中的通道并且还递送治疗剂的手术装置。 该装置包括细长多腔管，细长组织消融组件和治疗剂递送组件。 治疗剂能够被输送到通道和/或周围组织中。 该装置还可以包括还能够递送治疗剂的第二多腔管。 尽管适用于许多操作，该装置特别适用于经心肌血运重建操作。 本发明还考虑了使用这种外科装置消融患者组织中的通道并递送治疗剂的程序。

公开(公告)号：US20110288469A1

公开(公告)日：2011-11-24

申请号：US13194612

申请日：2011-07-29

申请人： John McIntyre ,  Elbert Tzeng

发明人： John McIntyre ,  Elbert Tzeng

IPC分类号： A61M37/00

CPC分类号： A61B17/3478 ,  A61B18/1477 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2018/00166 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61B2018/2005

摘要： A surgical device is provided for both ablating a channel in a patient's tissue and also delivering a therapeutic agent. The device includes an elongated multi-lumen tube, an elongated tissue ablating assembly, and a therapeutic agent delivery assembly. The therapeutic agent is capable of being delivered into the channel and/or to the surrounding tissue. The device may further include a second multi-lumen tube also capable of delivering therapeutic agents. A method is also provided for using such a surgical device to ablate a channel in a patient's tissue and also deliver a therapeutic agent to the tissue, for example, for transmyocardial revascularization or other procedures.

摘要翻译： 提供外科装置用于消融患者组织中的通道并且还递送治疗剂。 该装置包括细长多腔管，细长组织消融组件和治疗剂递送组件。 治疗剂能够被输送到通道和/或周围组织中。 该装置还可以包括还能够递送治疗剂的第二多腔管。 还提供了一种使用这种手术装置来消融患者组织中的通道并且还将治疗剂递送至组织的方法，例如用于经心肌血运重建或其它手术。

公开(公告)号：US06716236B1

公开(公告)日：2004-04-06

申请号：US10045936

申请日：2001-10-19

申请人： Elbert Tzeng ,  Peter Barker ,  Scott M. Evans ,  Wayne A. Noda

发明人： Elbert Tzeng ,  Peter Barker ,  Scott M. Evans ,  Wayne A. Noda

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61M25/1011

摘要： An intravenous catheter system (apparatus and method) for controlling patient temperature includes a generally tubular elongate body, a heat exchange element through which a heat exchange fluid circulates, and an inflation element or irregular surface positioned within the heat exchange element for promoting mixing of the circulating heat exchange fluid. The heat exchange element and inflation element preferably include inflatable balloons. The catheter preferably has two to four balloons having a substantially straight configuration, each balloon containing an inner balloon inflation element having a substantially spiral configuration. The catheter also preferably has at least one infusion lumen for providing access to the patient's blood and a guidewire lumen to accommodate a guidewire. The catheter is used in conjunction with a heat/cool system to cool a hyperthermic patient as quickly as possible, to warm a hypothermic patient as quickly as possible or to maintain normothermia.

摘要翻译： 用于控制患者体温的静脉内导管系统（装置和方法）包括大致管状的细长体，热交换流体循环通过的热交换元件和位于热交换元件内的充气元件或不规则表面，用于促进 循环热交换流体。 热交换元件和充气元件优选地包括可充气气球。 导管优选地具有两至四个具有基本上直的构造的气囊，每个球囊包含具有基本上螺旋形构造的内球囊膨胀元件。 导管还优选地具有至少一个用于提供对患者血液的通路和用于容纳导丝的导丝管腔的输液腔。 导管与热/冷系统一起使用以尽可能快地冷却高热患者，以尽可能快地温热低温患者或维持正常体温。

公开(公告)号：US20120226341A1

公开(公告)日：2012-09-06

申请号：US13408952

申请日：2012-02-29

申请人： Stefan Schreck ,  Elbert Tzeng ,  Todd Abraham ,  Jonathan Phan ,  Joshua Benjamin ,  Jacqueline Macias ,  Kevin Chu ,  William L. Gould

发明人： Stefan Schreck ,  Elbert Tzeng ,  Todd Abraham ,  Jonathan Phan ,  Joshua Benjamin ,  Jacqueline Macias ,  Kevin Chu ,  William L. Gould

IPC分类号： A61F2/82

CPC分类号： A61F2/966 ,  A61F2/07 ,  A61F2/90 ,  A61F2/954 ,  A61F2002/9517 ,  A61F2002/9665 ,  A61M25/0097 ,  A61M25/0662 ,  A61M2025/09125

摘要： A modular catheter system including a sheath projecting distally from a delivery catheter having a main body module An inner core module carrying a stent thereon, the inner core being axially movable through the main body of the delivery catheter and the delivery catheter sheath, a handle member supported by the main body of the delivery catheter, the handle member being selectively axially engageable with the inner core such that the handle member and the inner core move together in an axial direction when the handle member is engaged with the inner core; and an adjustment member supported by the main body, the adjustment member being configured such that rotation of the adjustment member causes the adjustment member to move axially along the main body by either axially sliding the handle member relative to the main body or by rotating the adjustment member.

摘要翻译： 一种模块化导管系统，包括从具有主体模块的输送导管向远侧突出的鞘。所述内芯模块在其上承载支架，所述内芯可轴向移动通过所述输送导管的主体和所述输送导管护套， 所述手柄构件由所述输送导管的主体支撑，所述手柄构件与所述内芯选择性地可轴向接合，使得当所述手柄构件与所述内芯接合时，所述手柄构件和所述内芯在轴向方向一起移动; 以及由所述主体支撑的调节构件，所述调节构件被构造成使得所述调节构件的旋转使得所述调节构件通过相对于所述主体轴向滑动所述把手构件或通过使所述调节部的旋转而沿着所述主体轴向移动 会员。

公开(公告)号：US20110218617A1

公开(公告)日：2011-09-08

申请号：US13039157

申请日：2011-03-02

申请人： Jonathon Nguyen ,  Jacqueline Macias ,  Elbert Tzeng ,  Stefan Schreck

发明人： Jonathon Nguyen ,  Jacqueline Macias ,  Elbert Tzeng ,  Stefan Schreck

IPC分类号： A61F2/82

CPC分类号： A61F2/82

摘要： Some embodiments of an endoluminal prosthesis comprise a graft having a first end and a second end, a first stent positioned at a first end of the graft, the first stent comprising a plurality of proximal apices and a plurality of distal apices, a second stent positioned axially adjacent to the first stent comprising a plurality of proximal apices positioned at a first end of the second stent. In some embodiments, the first stent can be partially covered by the graft such that the proximal apices of the first stent are not covered by the graft. The distal apices of the first stent can be positioned approximately on a first or a second plane offset from the first plane. The second stent can be positioned relative to the first stent such that the plurality of proximal apices of the second stent are spaced apart from the plurality of distal apices of the first stent. Further, one or more of the proximal apices of the second stent can be positioned approximately on a third or a fourth plane. The distal apices of the first stent can be circumferentially offset from the proximal apices of the second stent.

摘要翻译： 腔内假体的一些实施例包括具有第一端和第二端的移植物，位于移植物的第一端的第一支架，第一支架包括多个近侧顶点和多个远侧顶点，第二支架定位 轴向邻近第一支架，其包括位于第二支架第一端的多个近端顶点。 在一些实施例中，第一支架可以被移植物部分地覆盖，使得第一支架的近端顶端不被移植物覆盖。 第一支架的远端顶点可以大致位于从第一平面偏移的第一或第二平面上。 第二支架可以相对于第一支架定位，使得第二支架的多个近侧顶点与第一支架的多个远端顶点间隔开。 此外，第二支架的近侧顶点中的一个或多个可以大致位于第三或第四平面上。 第一支架的远侧顶点可以从第二支架的近端顶端周向偏移。

公开(公告)号：US08808350B2

公开(公告)日：2014-08-19

申请号：US13408952

申请日：2012-02-29

申请人： Stefan Schreck ,  Elbert Tzeng ,  Todd Abraham ,  Jonathan Phan ,  Joshua Benjamin ,  Jacqueline Macias ,  Kevin Chu ,  William L. Gould

发明人： Stefan Schreck ,  Elbert Tzeng ,  Todd Abraham ,  Jonathan Phan ,  Joshua Benjamin ,  Jacqueline Macias ,  Kevin Chu ,  William L. Gould

IPC分类号： A61F2/06

CPC分类号： A61F2/966 ,  A61F2/07 ,  A61F2/90 ,  A61F2/954 ,  A61F2002/9517 ,  A61F2002/9665 ,  A61M25/0097 ,  A61M25/0662 ,  A61M2025/09125

摘要： A modular catheter system including a sheath projecting distally from a delivery catheter having a main body module An inner core module carrying a stent thereon, the inner core being axially movable through the main body of the delivery catheter and the delivery catheter sheath, a handle member supported by the main body of the delivery catheter, the handle member being selectively axially engageable with the inner core such that the handle member and the inner core move together in an axial direction when the handle member is engaged with the inner core; and an adjustment member supported by the main body, the adjustment member being configured such that rotation of the adjustment member causes the adjustment member to move axially along the main body by either axially sliding the handle member relative to the main body or by rotating the adjustment member.

摘要翻译： 一种模块化导管系统，包括从具有主体模块的输送导管向远侧突出的鞘。所述内芯模块在其上承载支架，所述内芯可轴向移动通过所述输送导管的主体和所述输送导管护套， 所述手柄构件由所述输送导管的主体支撑，所述手柄构件与所述内芯选择性地可轴向接合，使得当所述手柄构件与所述内芯接合时，所述手柄构件和所述内芯在轴向方向一起移动; 以及由所述主体支撑的调节构件，所述调节构件被构造成使得所述调节构件的旋转使得所述调节构件通过相对于所述主体轴向滑动所述把手构件或通过使所述调节部的旋转而沿着所述主体轴向移动 会员。

公开(公告)号：US06706060B2

公开(公告)日：2004-03-16

申请号：US10160220

申请日：2002-05-30

申请人： Elbert Tzeng ,  Wesley Adzich ,  Peter Barker ,  Hortensia Pompa ,  Scott M. Evans

发明人： Elbert Tzeng ,  Wesley Adzich ,  Peter Barker ,  Hortensia Pompa ,  Scott M. Evans

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61F2007/126

摘要： A heat exchange catheter has a catheter body with a working fluid supply lumen extending therethrough, and terminating in a helical heat exchange tube that exits the body and extends proximally back along the catheter body. Working fluid flows through the heat exchange tube to exchange heat with the central venous system of a patient when the catheter body is properly placed in the patient.

摘要翻译： 热交换导管具有导管体，其具有延伸穿过其中的工作流体供应腔，并且终止于离开身体并沿导管主体向近侧延伸的螺旋形热交换管。 当导管主体适当地放置在患者体内时，工作流体流过热交换管以与患者的中心静脉系统进行热交换。

公开(公告)号：US06589271B1

公开(公告)日：2003-07-08

申请号：US10015505

申请日：2001-12-13

申请人： Elbert Tzeng ,  Vaso Adzich ,  Hortensia Pompa ,  Scott M. Evans ,  Peter Barker ,  William J. Worthen ,  Suzanne C. Winter ,  David P. Balding ,  Kenneth A. Collins

发明人： Elbert Tzeng ,  Vaso Adzich ,  Hortensia Pompa ,  Scott M. Evans ,  Peter Barker ,  William J. Worthen ,  Suzanne C. Winter ,  David P. Balding ,  Kenneth A. Collins

IPC分类号： A61F700

CPC分类号： A61N1/39 ,  A61B2018/00011 ,  A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/1011 ,  A61N1/36017

摘要： Catheters adapted to exchange heat with a body fluid flowing through a body conduit employ helical elongate lumens for heat transfer with the body fluid. The helical elongate lumen of a catheter forms multiple turns extending longitudinally of a portion of the catheter with the turns each being bonded to the catheter along a fraction of the length of the turn. The length of the lumen and its orientation in each turn has the lumen otherwise displaced over a major portion of its length from the elongate body. The turns of the helical lumen can be arranged in sets having different lengths to encounter all areas of the flow. One or more infusion lumens may also extend to an infusion port or ports. The helical elongate lumen is defined by an elongate, thin-walled element. This lumen is in fluid communication with a heater/chiller supplying a working fluid for heat transfer through the wall of the elongate element defining the helical elongate lumen. A proximal hub may be associated with the catheter to establish at least one suture anchor and to receive the heater/chiller flow through input and output lumens associated with the catheter and in fluid communication with the helical elongate lumens. The elongated lumens may also be arranged in non-helical arrangements such as in a semi-circular configuration, a figure-eight loop configuration or a random loop configuration.

摘要翻译： 适于与流过身体导管的体液交换热量的导管采用螺旋形细长腔，用于与体液的热传递。 导管的螺旋细长内腔形成多个匝，导管沿导管的一部分纵向延伸，匝各自沿转弯长度的一部分与导管接合。 内腔的长度及其在每一个回合中的取向具有内腔，其长度方向与细长主体相距很大一部分。 螺旋腔的匝数可以以具有不同长度的组合排列以遇到流动的所有区域。 一个或多个输注腔也可以延伸到输注端口。 螺旋细长的内腔由细长的薄壁元件限定。 该内腔与加热器/冷却器流体连通，加热器/冷却器供应用于通过限定螺旋细长内腔的细长元件的壁进行热传递的工作流体。 近端毂可以与导管相关联，以建立至少一个缝线锚，并且通过与导管相关联并与螺旋细长腔流体连通的输入和输出腔来接收加热器/制冷机流。 细长的腔也可以以非螺旋布置的方式布置，例如半圆形配置，图八循环配置或随机环配置。