Methylation of Gene Promoters as a Predictor of Effectiveness of Therapy
    4.
    发明申请
    Methylation of Gene Promoters as a Predictor of Effectiveness of Therapy 审中-公开
    基因启动子的甲基化作为治疗有效性的预测因子

    公开(公告)号:US20080299566A1

    公开(公告)日:2008-12-04

    申请号:US12097427

    申请日:2006-12-18

    IPC分类号: C12Q1/68

    摘要: The present invention provides methods for identifying, diagnosing, evaluating or monitoring a disease state in a subject comprising identifying the methylation status of a panel of genes in the subject. The present invention also relates to identifying, diagnosing, evaluating or monitoring the responsiveness of a subject to a therapeutic regimen, with the methods comprising determining the methylation status of a panel of genes in the subject.

    摘要翻译: 本发明提供用于鉴定,诊断,评估或监测受试者中疾病状态的方法,包括鉴定受试者中一组基因的甲基化状态。 本发明还涉及鉴定,诊断,评估或监测受试者对治疗方案的反应性,其方法包括测定受试者中一组基因的甲基化状态。

    Alkoxyalkyl phosphate plasticizing compositions
    7.
    发明授权
    Alkoxyalkyl phosphate plasticizing compositions 失效
    磷酸烷氧基烷基酯增塑组合物

    公开(公告)号:US4207225A

    公开(公告)日:1980-06-10

    申请号:US18195

    申请日:1979-03-06

    IPC分类号: C08K5/521 C08K5/49 C09K3/28

    CPC分类号: C08K5/521

    摘要: A plasticizing composition for polyvinyl chloride resin is prepared by mixing from about 20 to about 50 parts by weight of tris(alkoxyalkyl)phosphate having the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are alkoxyalkyl radicals having the formula: ##STR2## wherein n is an integer from 1 to 18; x is an integer from 1 to 2;R' is either hydrogen or an alkyl radical, andR" is either hydrogen or an alkyl radical;in combination with from about 80 to about 50 parts by weight of another phosphate ester selected from the group consisting triaryl phosphate, alkyl diphenyl phosphate, trialkyl phosphate, tris(alkylphenyl)phosphate, alkylphenyl/phenyl phosphate, and mixture thereof. Polyvinyl chloride resins plasticized with 30 or more parts per hundred of such phosphate ester plasticizer mixtures are heat stable, fire resistant and flexible at low temperatures.

    摘要翻译: 通过混合约20至约50重量份具有下式的三(烷氧基烷基)磷酸酯制备聚氯乙烯树脂的增塑组合物,其中R1,R2和R3是具有下式的烷氧基烷基:其中n 是1到18的整数; x是1到2的整数; R'是氢或烷基,R“是氢或烷基; 与约80至约50重量份的另一种磷酸酯,选自磷酸三芳基酯,磷酸烷基二苯酯,磷酸三烷基酯,磷酸三(烷基苯基)酯,烷基苯基/苯基磷酸酯及其混合物。 每100份这种磷酸酯增塑剂混合物增塑30份或更多份的聚氯乙烯树脂在低温下是稳定的,耐火的和柔韧的。