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公开(公告)号：US20140294733A1
公开(公告)日：2014-10-02
申请号：US14363185
申请日：2012-11-20
申请人： James R. BAKER, JR. , Baohua M. HUANG , Thommey P. THOMAS , The Regents of the university of Michigan
IPC分类号： A61K47/48 , A61K49/10 , A61K31/519
CPC分类号： A61K47/48023 , A61K31/519 , A61K45/06 , A61K47/54 , A61K47/595 , A61K49/10 , C08G73/028 , C08G83/004 , C08L101/005 , A61K2300/00
摘要： The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.
摘要翻译： 本发明涉及树枝状大分子合成。 具体地，本发明涉及能够用于合成官能化树枝状大分子的无铜点击共轭的树枝状大分子组合物（例如，支架）及其使用方法。
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公开(公告)号：US20120171227A1
公开(公告)日：2012-07-05
申请号：US13378178
申请日：2010-06-30
IPC分类号： A61K31/4745 , C07K14/71 , C07K17/02 , C12N5/09 , A61K38/18 , A61K39/44 , A61K38/12 , A61P35/00 , C07D491/22 , C07K7/64
CPC分类号： A61K31/437 , A61K47/64
摘要： The present invention provides methods, compositions and applications for efficient, site-specific drug delivery using pro-drug complexes comprising therapeutic agents and one or more functional groups (e.g., imaging agents, targeting agents, and trigger agents). In particular, the present invention relates to pro-drug complexes comprising one or more functional groups conjugated with a therapeutic agent (e.g., a chemotherapeutic agent), methods of synthesizing the same, as well as systems and methods utilizing the therapeutic and diagnostic compositions (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.)).
摘要翻译： 本发明提供了使用包含治疗剂和一种或多种官能团（例如成像剂，靶向剂和触发剂）的前药复合物进行有效的位点特异性药物递送的方法，组合物和应用。 特别地，本发明涉及包含与治疗剂缀合的一种或多种官能团（例如化学治疗剂）的前药复合物，其合成方法以及利用治疗和诊断组合物的系统和方法（ 例如，在诊断和/或治疗设置中（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如，癌症）诊断和/或治疗中）））。
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公开(公告)号：US20120259114A1
公开(公告)日：2012-10-11
申请号：US13504046
申请日：2010-09-30
IPC分类号： C07D405/14
CPC分类号： C08G83/003 , A61K47/551 , A61K47/595
摘要： The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.
摘要翻译： 本发明涉及树枝状大分子合成。 具体地，本发明涉及能够进行功能化树枝状大分子的一步合成的点击化学的三嗪支架及其制造和使用方法。
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公开(公告)号：US20120277376A1
公开(公告)日：2012-11-01
申请号：US13547929
申请日：2012-07-12
IPC分类号： C08G69/48
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。
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公开(公告)号：US20090088376A1
公开(公告)日：2009-04-02
申请号：US12106876
申请日：2008-04-21
IPC分类号： A61K38/16 , G01N33/53 , A61P35/00 , A61K31/4985
CPC分类号： C08L101/005 , A61K47/64 , A61K49/0043 , A61K49/0054 , A61K49/0056 , Y02A90/26
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及用于疾病诊断和治疗（例如，癌症诊断和治疗）的基于树枝状大分子的组合物和系统。 组合物和系统包含用于靶向，成像，感测和/或提供治疗或诊断材料并监测对细胞或组织（例如肿瘤）的治疗的反应的一种或多种组分。
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公开(公告)号：US20090287005A1
公开(公告)日：2009-11-19
申请号：US12403179
申请日：2009-03-12
IPC分类号： C07D305/08
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。
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公开(公告)号：US20120177593A1
公开(公告)日：2012-07-12
申请号：US13383378
申请日：2010-07-20
IPC分类号： A61K31/785 , A61P19/02 , A61P35/00 , C08G73/02 , G01N33/53
CPC分类号： A61K49/0054 , A61K47/551 , A61K47/595 , A61K49/0043
摘要： The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
摘要翻译： 本发明涉及合成治疗和诊断树枝状大分子的新方法。 特别地，本发明涉及新颖的树枝状大分子缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置中（例如用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症，炎性疾病）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子缀合物可以进一步包含至少 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测对治疗的响应的两种不同组分。此外，本发明某些实施方案的新型合成方法在总反应时间和 简单。
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公开(公告)号：US20100160299A1
公开(公告)日：2010-06-24
申请号：US12570977
申请日：2009-09-30
申请人： James R. Baker, JR. , Xue-min Cheng , Abraham F.L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
发明人： James R. Baker, JR. , Xue-min Cheng , Abraham F.L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
IPC分类号： A61K31/5513 , C07D489/02 , A61K31/485 , C07D243/24 , C07D413/06 , A61K31/5377
CPC分类号： A61K47/483 , A61K31/485 , A61K47/595
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。
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公开(公告)号：US20140303123A1
公开(公告)日：2014-10-09
申请号：US14358948
申请日：2012-11-15
IPC分类号： A61K31/655 , G01N33/50
CPC分类号： A61K31/655 , A61K47/595 , G01N33/502
摘要： The present invention relates to compositions (e.g., dendrimer scaffolds) capable of click chemistry for use in synthesis of functionalized dendrimers within biological settings, and methods of use of the same.
摘要翻译： 本发明涉及能够在生物学环境中用于合成官能化树枝状大分子的点击化学的组合物（例如，树枝状大分子支架）及其使用方法。
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公开(公告)号：US20220282657A1
公开(公告)日：2022-09-08
申请号：US17526509
申请日：2021-11-15
IPC分类号： F01N3/28
摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi, and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
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