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21 条记录 (耗时 0.026 秒)

    S-aminoalkyl-s-arylsulfoximines as antiarrhythmic agents
    2.
    发明授权
    S-aminoalkyl-s-arylsulfoximines as antiarrhythmic agents 失效
    S-氨基烷基-S-芳基亚磺酰亚胺作为抗心律失常药

    公开(公告)号：US5187189A

    公开(公告)日：1993-02-16

    申请号：US643364

    申请日：1991-01-22

    申请人： Mark R. Hellberg ,  James R. Shanklin, Jr.

    发明人： Mark R. Hellberg ,  James R. Shanklin, Jr.

    IPC分类号： C07C381/10 ,  C07D295/088

    CPC分类号： C07D295/088 ,  C07C381/10

    摘要： This invention discloses novel sulfoximines having the formula: ##STR1## where Z is C.sub.1 -C.sub.6 alkylene and Y is alkyl, arylalkyl, acyl, carbamoyl, sulfonyl or alkoxycarbonyl. The invention compounds are useful in the treatment of Class II arrhythmia.

    摘要翻译： 本发明公开了具有下式的新型磺酰亚胺：其中Z为C1-C6亚烷基，Y为烷基，芳基烷基，酰基，氨基甲酰基，磺酰基或烷氧基羰基。 本发明化合物可用于治疗II级心律失常。

    Lubricating oil additives
    6.
    发明授权
    Lubricating oil additives 失效
    润滑油添加剂

    公开(公告)号：US6071862A

    公开(公告)日：2000-06-06

    申请号：US329433

    申请日：1999-06-10

    申请人： James R. Shanklin, Jr. ,  Naresh C. Mathur

    发明人： James R. Shanklin, Jr. ,  Naresh C. Mathur

    IPC分类号： C10M159/12

    CPC分类号： C10M159/12 ,  C10M2205/00 ,  C10M2205/02 ,  C10M2205/026 ,  C10M2205/04 ,  C10M2207/10 ,  C10M2207/129 ,  C10M2207/34 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2215/04 ,  C10M2215/042 ,  C10M2215/22 ,  C10M2215/221 ,  C10M2215/225 ,  C10M2215/226 ,  C10M2215/26 ,  C10M2215/30 ,  C10M2217/046 ,  C10M2217/06 ,  C10M2227/00 ,  C10N2240/10 ,  C10N2240/101 ,  C10N2240/104 ,  C10N2240/106

    摘要： A composition, comprising from about 20% to about 80% by weight of a diluent, prepared by reacting a mixture comprising(A) an esterified carboxy-containing interpolymer, said interpolymer being derived from at least two monomers, (i) one of said monomers being at least one of an aliphatic olefin containing from 2 to about 30 carbon atoms and a vinyl aromatic monomer and (ii) the other of said monomers being at least one alpha, beta-unsaturated acylating agent, and having, before esterification, M.sub.n determined by gel permeation chromatography ranging from about 8,000 to about 350,000, wherein from about 80% to about 99% of the carboxylic groups of said intelpolymer are esterified, wherein from about 80 to about 100% of the ester groups contain from 8 to about 23 carbon atoms and from 0 to about 20% of the ester groups contain from 2 to 7 carbon atoms, and(B) a hydrocarbyl substituted carboxylic acid or functional derivative thereof wherein the hydrocarbyl group comprises from about 10 to about 400 carbon atoms, with(C) an amine having an average of more than 1 condensable N--H groups, wherein from about 0 to about 95% of the diluent is present during the reacting and the product obtained from said reacting is further combined with additional diluent such that the total diluent comprises from about 20% to about 80% by weight of the total weight of the composition. Depending upon the relative amounts of reactant (A) and (B) used, a composition which acts primarily as a viscosity improver with dispersant properties (DVM) or primarily as a dispersant with viscosity improving properties (VMD)may be prepared or compositions with properties intermediate between these.

    摘要翻译： 一种组合物，其包含约20％至约80％重量的稀释剂，其通过使包含（A）含酯化羧基的互聚物，所述互聚物衍生自至少两种单体的混合物，（i）所述 单体是含有2至约30个碳原子的脂族烯烃和乙烯基芳族单体中的至少一种，和（ii）所述单体中的另一种是至少一种α，β-不饱和酰化剂，并且在酯化前具有+ E，ovs M + EE n通过约8,000至约350,000的凝胶渗透色谱测定，其中约80％至约99％的所述智力聚合物的羧基被酯化，其中约80至约100％的酯 基团含有8至约23个碳原子，0至约20％的酯基含有2至7个碳原子，和（B）烃基取代的羧酸或其官能衍生物，其中烃基包括 （C）具有平均多于1个可冷凝NH基团的胺，其中在反应期间存在约0至约95％的稀释剂，并且从所述反应获得的产物为 进一步与额外的稀释剂组合，使得总稀释剂占组合物总重量的约20重量％至约80重量％。 取决于所用的反应物（A）和（B）的相对量，可以制备主要作为粘度改进剂的分散剂性能（DVM）或主要作为具有粘度改进性能（VMD）的分散剂的组合物或具有性质的组合物 这些之间的中间。

    Method of producing an inhibitory effect on blood platelet aggregation
    9.
    发明授权
    Method of producing an inhibitory effect on blood platelet aggregation 失效
    产生对血小板聚集的抑制作用的方法

    公开(公告)号：US4313949A

    公开(公告)日：1982-02-02

    申请号：US234532

    申请日：1981-02-17

    申请人： James R. Shanklin, Jr. ,  Dwight A. Shamblee ,  David A. Walsh

    发明人： James R. Shanklin, Jr. ,  Dwight A. Shamblee ,  David A. Walsh

    IPC分类号： C07D295/185 ,  A61K31/535 ,  A61K31/165

    CPC分类号： C07D295/185

    摘要： Novel 2-amino-3-benzoyl-phenylacetamides are provided having the formula: ##STR1## wherein R represents hydrogen or lower alkyl, R.sup.1 and R.sup.2 represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R.sup.1 and R.sup.2 when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (--NH.sub.2), methylamino or dimethylamino, and n is 1 to 3 inclusive. The compounds exhibit anti-inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.

    摘要翻译： 提供了新的2-氨基-3-苯甲酰基 - 苯基乙酰胺，其具有下式：其中R表示氢或低级烷基，R 1和R 2表示氢，低级烷基，环烷基，苯基和被低级烷基，低级烷氧基，卤素 硝基和三氟甲基，当R 1和R 2与相邻的氮原子一起时可以形成杂环残基; X表示氢，低级烷基，低级烷氧基，卤素或三氟甲基; Y代表氢，低级烷基，低级烷氧基，卤素，三氟甲基，低级烷硫基，低级烷硫氧基或低级烷基二氧硫基; Am是伯氨基（-NH 2），甲基氨基或二甲基氨基，n是1〜3。 该化合物具有抗炎，解热，抗血小板聚集和止痛药理作用。

    Aryloxy and aryloxyalklazetidines as antiarrhythmic and anticonvulsant agents
    10.
    发明授权
    Aryloxy and aryloxyalklazetidines as antiarrhythmic and anticonvulsant agents 失效
    芳氧基和芳氧基亚油酸作为抗心律失常药和抗惊厥药

    公开(公告)号：US5130309A

    公开(公告)日：1992-07-14

    申请号：US684313

    申请日：1991-04-12

    申请人： James R. Shanklin, Jr. ,  Mark R. Hellberg

    发明人： James R. Shanklin, Jr. ,  Mark R. Hellberg

    IPC分类号： A61K31/395 ,  C07D205/04

    CPC分类号： A61K31/395 ,  C07D205/04

    摘要： Methods of treating cardiac arrhythmias and convulsions in warm-blooded animas and pharmaceutical compositions therefor are disclosed. The compounds useful in the methods of treatment and compositions are represented by the formula ##STR1## where n is 0 to 3 and R is H, C.sub.1 -C.sub.4 alkyl or arylalkyl and Ar is phenyl or substituted phenyl.

    摘要翻译： 公开了在温血动物及其药物组合物中治疗心律失常和抽搐的方法。 用于处理方法和组合物的化合物由式（I）表示，其中n为0至3，R为H，C 1 -C 4烷基或芳基烷基，Ar为苯基或取代的苯基。