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    Glycosides
    1.
    发明授权
    Glycosides 失效
    糖苷类

    公开(公告)号：US4675392A

    公开(公告)日：1987-06-23

    申请号：US673796

    申请日：1984-11-21

    申请人： Jan Dahmen ,  Torbjorn Frejd ,  Goran Magnusson ,  Ghazi Noori

    发明人： Jan Dahmen ,  Torbjorn Frejd ,  Goran Magnusson ,  Ghazi Noori

    IPC分类号： G01N33/53 ,  A61K39/385 ,  C07H3/06 ,  C07H15/04

    CPC分类号： C07H3/06 ,  A61K39/385 ,  A61K2039/6031 ,  A61K2039/6087

    摘要： An O-glycoside having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.m --Halwherein Hal is chlorine, bromine or iodine, m is an integer of 2-20 inclusive and n is an integer of 1 to 10, inclusive, with the proviso that when n=1 and m=2, the aldose is different from glucose;An O-glycoside having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.m --S--R--R'wherein n is an integer of from 1-10, inclusive, m is an integer of from 2-20, inclusive, R is selected from the group consisting of alkyl having at most 25 carbon atoms and aryl and R' is selected from the group consisting of H, CHO, CH(OR').sub.2, NO.sub.2, NH.sub.2, OH, SH, COOH, COOCH.sub.3, COOCH.sub.2 CH.sub.3, CONHNH.sub.2 and CON.sub.3, wherein R" is C.sub.1-4 -alkyl;A glycoconjugate having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.m --S--R--R"wherein n is an integer of from 1-10, inclusive, m is an integer of from 2-20, inclusive, R is selected from the group consisting of alkyl having at most 25 carbon atoms and aryl and R" constitutes a carrier;A bi-dentate O-glycoside having the general formula:[(sugar).sub.n --O--(CH.sub.2).sub.m --S--.sub.2 Rwherein m, n and R have the above meaning; and processes for their preparation.

    摘要翻译： 具有以下通式的O-糖苷：（糖）nO-（CH 2）m-Hal其中Hal为氯，溴或碘，m为2-20的整数，n为1至10的整数， 条件是当n = 1和m = 2时，醛糖不同于葡萄糖; 具有以下通式的O-糖苷：（糖）nO-（CH2）mSRR'，其中n为1-10的整数，包括端值，m为2-20的整数，其中R选自 由H，CHO，CH（OR'）2，NO2，NH2，OH，SH，COOH，COOCH3，COOCH2CH3，CONHNH2和CON3组成的组中由至多25个碳原子的烷基和芳基组成，R' 其中R“为C 1-4 - 烷基; 具有以下通式的糖缀合物：（糖）nO-（CH2）mSR-R“，其中n为1-10的整数，包括端值，m为2-20的整数，包括端值，R选自 由至多25个碳原子的烷基和芳基构成的基团，R“构成载体; 具有以下通式的双齿O-糖苷：[（糖）n-O-（CH2）m-S-2R其中m，n和R具有上述含义; 及其制备方法。