专利检索 ap:("Jan Poolman" OR "Michiel Stork" OR "Johannes Petrus Maria Tommassen" OR "Nathalie Isabelle Devos" OR "Vincent Weynants") AND inv:"Michiel Stork" 第 1 页

1.

发明申请
VACCINE 有权
标题翻译：疫苗

公开(公告)号：US20130004510A1

公开(公告)日：2013-01-03

申请号：US13583419

申请日：2011-03-11

申请人： Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Nathalie Isabelle Devos , Vincent Weynants

发明人： Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Nathalie Isabelle Devos , Vincent Weynants

IPC分类号： A61K39/02 , C07K14/22 , C12P21/02 , A61P31/04 , C07K14/285 , C07K14/21 , C07K14/205 , C07K14/235 , C07K14/195 , C07K16/12

CPC分类号： A61K39/095 , A61K39/00 , C07K14/195 , C07K14/22 , C07K16/1217 , Y02A50/401 , Y02A50/476 , Y02A50/478

摘要： Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.

摘要翻译： 本文提供了用于治疗或预防革兰氏阴性菌菌株感染的组合物和方法。本文还提供了制备所述组合物的方法。

2.

发明授权
Vaccine 有权
标题翻译：疫苗

公开(公告)号：US09365624B2

公开(公告)日：2016-06-14

申请号：US13583419

申请日：2011-03-11

申请人： Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Nathalie Isabelle Devos , Vincent Weynants

发明人： Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Nathalie Isabelle Devos , Vincent Weynants

IPC分类号： A61K39/095 , C07K14/195 , C07K14/21 , C07K14/22 , A61K39/00

CPC分类号： A61K39/095 , A61K39/00 , C07K14/195 , C07K14/22 , C07K16/1217 , Y02A50/401 , Y02A50/476 , Y02A50/478

摘要： Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.

摘要翻译： 本文提供了用于治疗或预防革兰氏阴性菌菌株感染的组合物和方法。本文还提供了制备所述组合物的方法。

3.

发明申请
Vaccine Comprising Protein NMB0964 From Neisseria Meningitidis 有权
标题翻译：疫苗包括脑膜炎奈瑟氏球菌蛋白NMB0964

公开(公告)号：US20110189215A1

公开(公告)日：2011-08-04

申请号：US13062319

申请日：2009-03-06

申请人： Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants

发明人： Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants

IPC分类号： A61K39/095 , A61K39/00 , A61P31/04 , A61P37/04

CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/575 , C07K14/22 , C12P21/00

摘要： The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.

摘要翻译： 本发明涉及包含具有上调NMB0964抗原水平的奈瑟氏球菌的免疫原性组合物，使得针对所述抗原产生细菌抗体。还提供了通过去除细胞或启动子的锌抑制机制或通过从培养基中除去锌来上调表达的方法。

4.

发明授权
Vaccine comprising protein NMB0964 from Neisseria meningitidis 有权
标题翻译：疫苗包含来自脑膜炎奈瑟氏球菌的蛋白质NMB0964

公开(公告)号：US09259461B2

公开(公告)日：2016-02-16

申请号：US13062319

申请日：2009-03-06

申请人： Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants

发明人： Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants

IPC分类号： A61K39/00 , A61K39/095 , A61P31/04 , C12P21/00 , C07K14/22

CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/575 , C07K14/22 , C12P21/00

摘要： The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.

摘要翻译： 本发明涉及包含具有上调NMB0964抗原水平的奈瑟氏球菌的免疫原性组合物，使得针对所述抗原产生细菌抗体。还提供了通过去除细胞或启动子的锌抑制机制或通过从培养基中除去锌来上调表达的方法。