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公开(公告)号：US4343734A
公开(公告)日：1982-08-10
申请号：US111115
申请日：1980-01-10
申请人： Jane B. Lian , Robert J. Levy , Paul M. Gallop
发明人： Jane B. Lian , Robert J. Levy , Paul M. Gallop
CPC分类号： A61K35/44 , G01N33/531 , A61K39/00 , Y10S530/829 , Y10S530/841
摘要： Compositions and processes featuring, in one aspect, a process of purifying a protein diagnostic for atherosclerosis comprising separating out of primate and human atherosclerotic tissue a Gla-containing protein of molecular weight of about 80,000.
摘要翻译： 组合物和方法在一个方面特征在于提供一种纯化动脉粥样硬化蛋白质诊断的方法，其中包括从灵长类动物和人类动脉粥样硬化组织中分离出约80,000分子量的含Gla蛋白质。
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公开(公告)号：US4634722A
公开(公告)日：1987-01-06
申请号：US527550
申请日：1983-08-29
申请人： Paul M. Gallop
发明人： Paul M. Gallop
IPC分类号： C08F220/12 , C08F220/26 , C08F220/38 , C08F230/06 , G02B1/04 , C08F22/20
CPC分类号： G02B1/043 , C08F220/12 , C08F220/26 , C08F220/38 , C08F230/06
摘要： Copolymers having improved machining and water resistant properties are produced using a monomer containing an adduct protecting group, particularly an alkyl boronic acid adduct, of glyceryl acrylate or glyceryl methacrylate, in combination with an alkyl acrylate or methacrylate, and optionally a glycidyl acrylate or methacrylate. After machining and shaping, the adduct is removed to provide a hydrogel useful as a contact lens material.
摘要翻译： 具有改善的机械加工性和耐水性的共聚物使用含有丙烯酸甘油酯或甲基丙烯酸甘油酯的加合物保护基团，特别是烷基硼酸加合物与丙烯酸烷基酯或甲基丙烯酸烷基酯和任选的丙烯酸缩水甘油酯或甲基丙烯酸缩水甘油酯组合的单体制备。 在机械加工和成形之后，除去加合物以提供可用作隐形眼镜材料的水凝胶。
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公开(公告)号：US4543371A
公开(公告)日：1985-09-24
申请号：US466274
申请日：1983-02-14
申请人： Paul M. Gallop , Donald R. Korb
发明人： Paul M. Gallop , Donald R. Korb
IPC分类号： A01N25/10 , A61K6/08 , A61K9/20 , B29D11/02 , C08F220/28 , C08F220/20
CPC分类号： C08F220/28 , A01N25/10 , A61K6/08 , A61K9/2027 , B01D71/40 , B29D11/02 , B01D2323/30 , B01D61/025 , B01D61/145 , B01D61/246
摘要： The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
摘要翻译： 本发明提供了新的水凝胶形成材料，其包括由亲水性丙烯酸酯或甲基丙烯酸二羟烷基酯，基本上不溶于水的丙烯酸烷基酯或甲基丙烯酸烷基酯，一种或多种另外的亲水共聚单体共聚形成的合成的，亲水的，不溶于水的聚合物网络，所述共聚单体选自乙烯基单体 ，丙烯酸酯和甲基丙烯酸酯，以及交联剂。 水凝胶优选用于形成隐形眼镜，但也可用于药物和农药递送装置; 透析，超滤和反渗透膜; 手术和牙科植入物; 等等。
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公开(公告)号：US4338419A
公开(公告)日：1982-07-06
申请号：US184596
申请日：1980-09-05
申请人： Donald R. Korb , Paul M. Gallop
发明人： Donald R. Korb , Paul M. Gallop
CPC分类号： G02B1/043 , B29D11/00 , B29D11/00038
摘要： The invention provides a method of treating hydrogels formed from the polymerization of monomers having reactive olefinic double bonds by contacting them with reactive thiol compounds. In a preferred embodiment where the hydrogel structure includes a cis-glycol containing unit, a suitable thiol is used in conjunction with a borate buffer. The present invention also provides materials that are treated with the above thiol compounds.
摘要翻译： 本发明提供了一种处理由具有反应性烯属双键的单体的聚合形成的水凝胶的方法，通过使它们与反应性硫醇化合物接触。 在其中水凝胶结构包含含顺式二醇单元的优选实施方案中，合适的硫醇与硼酸盐缓冲液结合使用。 本发明还提供用上述硫醇化合物处理的材料。
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公开(公告)号：US4267295A
公开(公告)日：1981-05-12
申请号：US10992
申请日：1979-02-09
申请人： Paul M. Gallop , Donald R. Korb
发明人： Paul M. Gallop , Donald R. Korb
IPC分类号： A01N25/10 , A61K6/083 , A61K9/20 , A61L27/16 , A61L33/06 , B01D71/40 , B29D11/02 , C08F220/28 , C08F220/20
CPC分类号： C08F220/28 , A01N25/10 , A61K6/083 , A61K9/2027 , A61L27/16 , A61L33/064 , B01D71/40 , B29D11/02 , Y10S528/92
摘要： The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
摘要翻译： 本发明提供了新的水凝胶形成材料，其包括由亲水性丙烯酸酯或甲基丙烯酸二羟烷基酯，基本上不溶于水的丙烯酸烷基酯或甲基丙烯酸烷基酯，一种或多种另外的亲水共聚单体共聚形成的合成的，亲水的，不溶于水的聚合物网络，所述共聚单体选自乙烯基单体 ，丙烯酸酯和甲基丙烯酸酯，以及交联剂。 水凝胶优选用于形成隐形眼镜，但也可用于药物和农药递送装置; 透析，超滤和反渗透膜; 手术和牙科植入物; 等等。
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6.发明授权Controlling bone resorption with pyrroloquinoline quinone (PQQ) and related compounds 失效用吡咯喹啉醌（PQQ）和相关化合物控制骨吸收
公开(公告)号：US5616576A
公开(公告)日：1997-04-01
申请号：US274193
申请日：1994-07-12
申请人： Peter V. Hauschka , Paul M. Gallop
发明人： Peter V. Hauschka , Paul M. Gallop
IPC分类号： A61K31/4745 , A61K31/675 , A61K31/44
CPC分类号： A61K31/4745 , A61K31/675
摘要： PQQ and PQQ-generating compounds inhibit osteoclast cell formation and bone resorption, and those compounds can be used to treat medical conditions characterized by undesired bone resorption. PQQ-phosphonates that target osteoclasts at the bone-mineral interface are particularly useful in this regard.
摘要翻译： PQQ和产生PQQ的化合物抑制破骨细胞形成和骨吸收，并且这些化合物可用于治疗以不期望的骨吸收为特征的医学病症。 在骨矿物界面上靶向破骨细胞的PQQ-膦酸盐在这方面特别有用。
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公开(公告)号：US5091391A
公开(公告)日：1992-02-25
申请号：US568301
申请日：1990-08-16
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： A method for resisting neurological damage caused by overstimulation of theMDA receptor of nerve cells by glutamate includes exposing the NMDA receptors to an oxidizing agent to thereby diminish overall activity of the receptors following activation by glutamate. The oxidizing agent preferably is a material selected from the group consisting of pyrroloquinoline quinone and topa hydantoin.
摘要翻译： 由谷氨酸过度刺激神经细胞的NMDA受体引起的神经损伤的方法包括将NMDA受体暴露于氧化剂，从而在谷氨酸激活后降低受体的整体活性。 氧化剂优选为选自吡咯并喹啉醌和拓扑乙内酰脲的材料。
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公开(公告)号：US4379864A
公开(公告)日：1983-04-12
申请号：US240739
申请日：1981-03-05
申请人： Paul M. Gallop , Donald R. Korb
发明人： Paul M. Gallop , Donald R. Korb
IPC分类号： A01N25/10 , A61K6/083 , A61K9/20 , A61L27/16 , A61L27/52 , A61L33/00 , A61L33/06 , B01D71/40 , B29D11/02 , C08F220/28 , G02B1/04 , C08F220/20
CPC分类号： C08F220/28 , A01N25/10 , A61K6/083 , A61K9/2027 , A61L27/16 , A61L27/52 , A61L33/0064 , A61L33/064 , B01D71/40 , B29D11/02 , G02B1/043
摘要： The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
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公开(公告)号：US4268270A
公开(公告)日：1981-05-19
申请号：US34755
申请日：1979-04-30
申请人： Kenneth H. Gabbay , Paul M. Gallop
发明人： Kenneth H. Gabbay , Paul M. Gallop
CPC分类号： G01N33/723 , G01N33/726
摘要： Process and apparatus for measuring glycosylated hemoglobin by assaying bound glyco groups in hemolysate featuring, in one aspect, appropriate oxidation of glycosylated hemoglobin and the rapid measurement of the resultant aldehydic compounds.
摘要翻译： 测定糖基化血红蛋白的方法和装置，通过测定溶血液中结合的糖基团，其特征在于一方面，糖基化血红蛋白的适当氧化和所得醛化合物的快速测量。
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公开(公告)号：US5460819A
公开(公告)日：1995-10-24
申请号：US910608
申请日：1992-07-06
申请人： Paul M. Gallop , Mercedes A. Paz
发明人： Paul M. Gallop , Mercedes A. Paz
CPC分类号： A61K47/48161 , A61K31/47
摘要： Methods are disclosed for treating PQQ-responsive heavy metal toxicity which include the administration of PQQ to a patient in need thereof. The toxicity may be associated with such heavy metals as lead, indium and vanadium.
摘要翻译： 公开了用于治疗PQQ反应性重金属毒性的方法，其包括向有需要的患者施用PQQ。 毒性可能与铅，铟和钒等重金属有关。
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